Reactome | CPSF6(1-490)-FGFR1(429-822) fusion [cytosol]

CPSF6(1-490)-FGFR1(429-822) fusion [cytosol]

Stable Identifier

R-HSA-1614368

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CPSF6-FGFR1 fusion, t(8:12) CPSF6-FGFR1 fusion

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
18205209	The t(1;9)(p34;q34) and t(8;12)(p11;q15) fuse pre-mRNA processing proteins SFPQ (PSF) and CPSF6 to ABL and FGFR1 Hidalgo-Curtis, C, Chase, A, Drachenberg, M, Roberts, MW, Finkelstein, JZ, Mould, S, Oscier, D, Cross, NC, Grand, FH	Genes Chromosomes Cancer	2008

External Reference Information

External Reference

UniProt:Q16630 CPSF6

Gene Names

CPSF6, CFIM68

Chain

chain:1-551

Reference Genes

BioGPS Gene:11052 CPSF6

COSMIC (genes):CPSF6 CPSF6

CTD Gene:11052 CPSF6

dbSNP Gene:11052 CPSF6

ENSEMBL:ENSG00000111605 CPSF6

HGNC:13871 CPSF6

KEGG:hsa:11052 CPSF6

Monarch:11052 CPSF6

NCBI Gene:11052 CPSF6

OMIM:604979 CPSF6

UCSC:Q16630 CPSF6

Reference Transcript

Participates

as a candidate of

cytosolic FGFR1 fusion mutants [cytosol] (Homo sapiens)

as a component of

CPSF6-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)

Other forms of this molecule

CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol]

Modified Residues

Name

Insertion of residues 429 to 822 at 491 from UniProt:P11362 FGFR1

Coordinate

491

Disease

Name	Identifier	Synonyms
subacute leukemia	DOID:3264
myelodysplastic myeloproliferative cancer	DOID:4972	Myeloproliferative/Myelodysplastic syndromes, unclassifiable myelodysplastic myeloproliferative disease, Unclassifiable Myeloproliferative/Myelodysplastic syndrome, Myelodysplastic/myeloproliferative disease (morphologic abnormality)
acute lymphocytic leukemia	DOID:9952

Cross References

RefSeq

NP_008938.2, NP_001287876.1

ENSEMBL

ENST00000435070, ENST00000266679, ENSP00000266679, ENSG00000111605, ENSP00000391774

OpenTargets

ENSG00000111605

Mondo

0002582

GeneCards

CPSF6

HPA

ENSG00000111605-CPSF6

PRO

Q16630

Pharos - Targets

Q16630

GlyGen

Q16630

PDB

7ZUD, 9CNV, 6AY9, 3P6Y, 3Q2T, 8GDV, 4B4N, 8EJL, 4U0B, 3Q2S, 4U0A, 7SNQ, 6GX9, 8CL1, 3P5T, 4WYM

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43809 NUDT21	1	NUDT21 [nucleoplasm] (R-HSA-72010)	0.889	10
UniProt:Q9H0M0 WWP1	1	WWP1 [cytosol] (R-HSA-976037)	0.783	6
UniProt:Q9Y3C6 PPIL1	1	PPIL1 [nucleoplasm] (R-HSA-8867892)	0.666	4
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.659	4
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	3
UniProt:Q6NYC1 JMJD6	1	JMJD6 [nucleoplasm] (R-HSA-4754226)	0.527	3
UniProt:O60828 PQBP1	1	PQBP1 [nucleoplasm] (R-HSA-8867889)	0.527	2
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.527	2
UniProt:Q9UPT8 ZC3H4	1	ZC3H4 [nucleoplasm] (R-HSA-9930063)	0.483	2
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.483	2
UniProt:Q5VT52 RPRD2	1	RPRD2 [nucleoplasm] (R-HSA-6814906)	0.483	2
UniProt:Q9C0J8 WDR33	1	WDR33 [nucleoplasm] (R-HSA-8938784)	0.483	2
UniProt:Q14966 ZNF638	1	ZNF638 [nucleoplasm] (R-HSA-8939429)	0.483	2
UniProt:Q7Z6E9 RBBP6	2	RBBP6 [cytosol] (R-HSA-8850895) RBBP6 [nucleoplasm] (R-HSA-9970176)	0.483	2
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.483	2
UniProt:Q8IX12 CCAR1	1	CCAR1 [nucleoplasm] (R-HSA-72048)	0.483	2
UniProt:O95639 CPSF4	1	CPSF4 [nucleoplasm] (R-HSA-169104)	0.483	2
UniProt:Q96MU7 YTHDC1	1	YTHDC1 [nucleoplasm] (R-HSA-9935812)	0.483	2
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.483	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.483	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.483	2
UniProt:Q5T8P6 RBM26	1	RBM26 [nucleoplasm] (R-HSA-9935784)	0.483	2
UniProt:O14776 TCERG1	1	TCERG1 [nucleoplasm] (R-HSA-3246027)	0.483	2
UniProt:Q6UN15 FIP1L1	9	FIP1L1 [nucleoplasm] (R-HSA-6805150) FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9672499) FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol] (R-HSA-9672496) FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] (R-HSA-9672502) FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] (R-HSA-9672506) p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673872) p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] (R-HSA-9673621) p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] (R-HSA-9673879) p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol] (R-HSA-9673867)	0.483	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.483	3
UniProt:Q15424 SAFB	3	SAFB [nucleoplasm] (R-HSA-4085379) polySUMO2,3-K231,K294-SAFB [nucleoplasm] (R-HSA-4085357) monoSUMO1-K231,K294-SAFB [nucleoplasm] (R-HSA-4085343)	0.483	2
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.483	2
UniProt:Q9P2I0 CPSF2	1	CPSF2 [nucleoplasm] (R-HSA-71991)	0.483	2
UniProt:Q9BYW2 SETD2	1	SETD2 [nucleoplasm] (R-HSA-1183220)	0.483	2
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.483	2

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