Sulfite is oxidized to sulfate

Stable Identifier
R-HSA-1614544
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
H2O + O2 + sulfite => H2O2 + sulfate
ReviewStatus
5/5
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Sulfite is oxidized to sulfate
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Sulfite oxidase oxidizes sulfite to sulfate which is among the most important macronutrients in cells and the fourth most abundant anion in human plasma (300 micromolar). The enzyme has a molybdenum-molybdopterin cofactor (MoCo) bound (Wilson et al. 2006, Feng et al. 2007).
Literature References
PubMed ID Title Journal Year
16475804 The G473D mutation impairs dimerization and catalysis in human sulfite oxidase

Wilson, HL, Wilkinson, SR, Rajagopalan, KV

Biochemistry 2006
17459792 Sulfite oxidizing enzymes

Feng, C, Tollin, G, Enemark, JH

Biochim Biophys Acta 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

sulfite oxidase activity of holo-SUOX [mitochondrial matrix]

Physical Entity
holo-SUOX [mitochondrial matrix] (Homo sapiens)
Activity
sulfite oxidase activity (GO:0008482)
Orthologous Events
Sulfite is oxidized to sulfate (Bos taurus)
Sulfite is oxidized to sulfate (Caenorhabditis elegans)
Sulfite is oxidized to sulfate (Canis familiaris)
Sulfite is oxidized to sulfate (Danio rerio)
Sulfite is oxidized to sulfate (Dictyostelium discoideum)
Sulfite is oxidized to sulfate (Drosophila melanogaster)
Sulfite is oxidized to sulfate (Gallus gallus)
Sulfite is oxidized to sulfate (Mus musculus)
Sulfite is oxidized to sulfate (Rattus norvegicus)
Sulfite is oxidized to sulfate (Sus scrofa)
Sulfite is oxidized to sulfate (Xenopus tropicalis)
Cross References
RHEA
Authored
Stephan, R  (2010-10-24)
Reviewed
D'Eustachio, P  (2011-10-13)
Created
Jassal, B  (2011-09-29)
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