Reactome | PXLP-K119-CBS [cytosol]

PXLP-K119-CBS [cytosol]

Stable Identifier

R-HSA-1614563

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CBS, Cystathionine beta-synthase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P35520 CBS

Gene Names

CBS

Chain

chain:1-551

Reference Genes

BioGPS Gene:102724560 CBS

BioGPS Gene:875 CBS

COSMIC (genes):CBS CBS

CTD Gene:875 CBS

dbSNP Gene:102724560 CBS

dbSNP Gene:875 CBS

ENSEMBL:ENSG00000160200.18 CBS

HGNC:1550 CBS

KEGG Gene (Homo sapiens):102724560 CBS

KEGG Gene (Homo sapiens):875 CBS

Monarch:102724560 CBS

Monarch:875 CBS

NCBI Gene:102724560 CBS

NCBI Gene:875 CBS

OMIM:613381 CBS

UCSC:P35520 CBS

Reference Transcript

Other Identifiers

102724560

11744285_a_at

11744286_s_at

11744287_x_at

11744835_s_at

11745019_a_at

11752656_a_at

1553972_PM_a_at

1553972_a_at

16926111

212816_PM_s_at

212816_s_at

38474_at

3933924

3933925

3933926

3933932

3933940

3933941

3933942

3933945

3933948

3933950

3933952

3933954

3933955

3933956

3933957

3933958

3933961

3933962

3933965

3933966

3933974

3933975

3933976

3933977

8070632

875

A_23_P166306

GE57544

GO:0001958

GO:0001974

GO:0003013

GO:0003824

GO:0004122

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006520

GO:0006535

GO:0006563

GO:0006565

GO:0006790

GO:0006801

GO:0008152

GO:0008652

GO:0010749

GO:0012501

GO:0016491

GO:0016829

GO:0019343

GO:0019344

GO:0019346

GO:0019448

GO:0019825

GO:0019899

GO:0020037

GO:0021587

GO:0022414

GO:0023052

GO:0030170

GO:0031625

GO:0031667

GO:0036211

GO:0042262

GO:0042802

GO:0042803

GO:0043066

GO:0043167

GO:0043226

GO:0043418

GO:0043506

GO:0046872

GO:0048856

GO:0050421

GO:0050667

GO:0051593

GO:0060135

GO:0060351

GO:0070025

GO:0070026

GO:0070814

GO:0071456

GO:0072341

GO:0097746

GO:1904047

HMNXSV003006773

HMNXSV003012529

Hs.84152.2.S1_3p_s_at

ILMN_1804735

L00972_at

PH_hs_0022824

Participates

as a component of

PXLP-K119-CBS tetramer [cytosol] (Homo sapiens)

Inferred To

CBS [cytosol] (Bos taurus)

CBS [cytosol] (Sus scrofa)

cbs [cytosol] (Xenopus tropicalis)

PXLP-K119-CBS [cytosol] (Caenorhabditis elegans)

PXLP-K119-CBS [cytosol] (Canis familiaris)

PXLP-K119-CBS [cytosol] (Danio rerio)

PXLP-K119-CBS [cytosol] (Dictyostelium discoideum)

PXLP-K119-CBS [cytosol] (Drosophila melanogaster)

PXLP-K119-CBS [cytosol] (Gallus gallus)

PXLP-K119-CBS [cytosol] (Mus musculus)

PXLP-K119-CBS [cytosol] (Rattus norvegicus)

PXLP-K119-CBS [cytosol] (Saccharomyces cerevisiae)

Modified Residues

Name

N6-pyridoxal phosphate-L-lysine at 119

Coordinate

119

PsiMod Name

N6-pyridoxal phosphate-L-lysine [MOD:00128]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.

Cross References

RefSeq

XP_016883701.1, XP_016883979.1, NP_001171479.1, XP_011544396.1, XP_016883702.1, XP_011544401.1, XP_016883703.1, NP_001308002.1, XP_011544399.1, NP_001307227.1, XP_011544400.1, XP_011528079.1, XP_011544397.1, XP_016883704.1, XP_016883980.1, XP_016883705.1, NP_000062.1, XP_011528083.1, XP_016883981.1, XP_016883706.1, XP_016883707.1, XP_011528084.1, NP_001171480.1, XP_016883978.1, XP_016883700.1

Guide to Pharmacology - Targets

1443

OpenTargets

ENSG00000160200

HPA

ENSG00000160200-CBS

GeneCards

P35520

ZINC target

P35520

Ensembl

ENSP00000381225, ENSG00000160200, ENST00000398158, ENSP00000352643, ENST00000359624, ENSP00000344460, ENSP00000381231, ENST00000352178, ENST00000398165

PRO

P35520

Pharos - Targets

P35520

Orphanet

15404

HMDB Protein

HMDBP00779

PDB

7QGT, 5MMS, 4UUU, 4L3V, 4L27, 4PCU, 1JBQ, 4L28, 4COO, 4L0D, 1M54

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.666	4
UniProt:Q13526 PIN1	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.666	4
UniProt:O75344 FKBP6	2	FKBP6 [nucleoplasm] (R-HSA-912512) FKBP6 [cytosol] (R-HSA-5601923)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.556	3
UniProt:P22466 GAL	1	GAL [extracellular region] (R-HSA-389038)	0.556	3
UniProt:P17612 PRKACA	3	PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.556	3

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