Reactome | PXLP-K212-CTH cleaves L-Cystathionine

PXLP-K212-CTH cleaves L-Cystathionine

Stable Identifier

R-HSA-1614583

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

H2O + L,L-cystathionine => 2-oxobutanoate + L-cysteine + NH4(+)

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cystathionine is cleaved to cysteine, oxobutanoate, and ammonia by the alpha,gamma-elimination activity of cystathionine gamma-lyase (CTH). CTH utilises pyridoxal 5'-phosphate (PXLP) as cofactor (Chiku et al. 2009, Steegborn et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10212249	Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration Steegborn, C, Clausen, T, Sondermann, P, Jacob, U, Worbs, M, Marinkovic, S, Huber, R, Wahl, MC	J Biol Chem	1999
19261609	H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia Chiku, T, Padovani, D, Zhu, W, Singh, S, Vitvitsky, V, Banerjee, R	J Biol Chem	2009