Reactome | PXLP-K212-CTH cleaves L-Cystathionine

PXLP-K212-CTH cleaves L-Cystathionine

Stable Identifier

R-HSA-1614583

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cystathionine is cleaved to cysteine, oxobutanoate, and ammonia by the alpha,gamma-elimination activity of cystathionine gamma-lyase (CTH). CTH utilises pyridoxal 5'-phosphate (PXLP) as cofactor (Chiku et al. 2009, Steegborn et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10212249	Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration Marinkovic, S, Huber, R, Steegborn, C, Sondermann, P, Wahl, MC, Clausen, T, Worbs, M, Jacob, U	J Biol Chem	1999
19261609	H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia Zhu, W, Chiku, T, Padovani, D, Banerjee, R, Singh, S, Vitvitsky, V	J Biol Chem	2009