Excess cysteine yields lanthionine and H2S

Stable Identifier
R-HSA-1614591
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)
Literature References
PubMed ID Title Journal Year
10212249 Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration

Marinkovic, S, Huber, R, Steegborn, C, Sondermann, P, Wahl, MC, Clausen, T, Worbs, M, Jacob, U

J Biol Chem 1999
19261609 H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia

Zhu, W, Chiku, T, Padovani, D, Banerjee, R, Singh, S, Vitvitsky, V

J Biol Chem 2009
Participants
Input
Participates
Catalyst Activity

L-cysteine desulfhydrase activity of PXLP-K212-CTH tetramer [cytosol]

This event is regulated
Positively by
Regulator
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!