CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine

Stable Identifier
R-HSA-1614645
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cysteine is oxidized
ReviewStatus
5/5
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CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine
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Oxidation of the thiol moiety of cysteine yields sulfinoalanine, which itself is processed to hypotaurine by an as of yet uncharacterized enzyme in humans . Whether further oxidation of hypotaurine to taurine needs an enzyme is unknown at present (Ye et al. 2007).
Literature References
PubMed ID Title Journal Year
17135237 An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor

Wei, L, Bartlam, M, Tang, D, Ye, S, Rao, Z, Sun, P, Wu, X

J Biol Chem 2007
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
L-cysteine catabolic process (0019448)
Catalyst Activity

cysteine dioxygenase activity of CDO1:Fe2+ [cytosol]

Physical Entity
CDO1:Fe2+ [cytosol] (Homo sapiens)
Activity
cysteine dioxygenase activity (GO:0017172)
Orthologous Events
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Bos taurus)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Caenorhabditis elegans)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Canis familiaris)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Danio rerio)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Dictyostelium discoideum)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Drosophila melanogaster)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Gallus gallus)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Mus musculus)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Rattus norvegicus)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Sus scrofa)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Xenopus tropicalis)
Cross References
Rhea
Authored
Stephan, R  (2010-10-24)
Reviewed
D'Eustachio, P  (2011-10-13)
Created
Jassal, B  (2011-09-29)
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