CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine

Stable Identifier
R-HSA-1614645
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Cysteine is oxidized
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Oxidation of the thiol moiety of cysteine yields sulfinoalanine, which itself is processed to hypotaurine by an as of yet uncharacterized enzyme in humans . Whether further oxidation of hypotaurine to taurine needs an enzyme is unknown at present (Ye et al. 2007).
Literature References
PubMed ID Title Journal Year
17135237 An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor

Wei, L, Bartlam, M, Tang, D, Ye, S, Rao, Z, Sun, P, Wu, X

J Biol Chem 2007
Participants
Participates
Event Information
Catalyst Activity

cysteine dioxygenase activity of CDO1:Fe2+ [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!