Reactome | BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY

BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY

Stable Identifier

R-HSA-1614654

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Remethylation of homocysteine via betaine degradation

ReviewStatus

5/5

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BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY

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Remethylation of homocysteine (HCYS) to methionine (L-Met) can also proceed by using betaine (BET) as a methyl donor, which is oxidised to dimethylglycine (DMGLY). This reaction is also part of choline catabolism, thereby providing a link to folate-dependent, one-carbon metabolism (Li et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18457970	Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization Weinshilboum, RM, Eckloff, BW, Feng, Q, Li, F, Moon, I, Pelleymounter, LL, Schaid, DJ, Lee, C, Wang, S, Yee, V, Wieben, ED	Mol Genet Metab	2008