p-T309,S474-AKT2:PIP3 phosphorylates PDE3B

Stable Identifier
R-HSA-162363
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
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Based on work done in mouse with AKT1, AKT2 is predicted to phosphorylate PDE3B downstream of insulin signaling (Wijknader et al, 1998; Kitamura et al, 1999; Ahmad et al, 2000; reviewed in Degerman et al, 2011).

Literature References
PubMed ID Title Journal Year
9421418 Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase

Wijkander, J, Landström, TR, Degerman, E, Manganiello, V, Belfrage, P

Endocrinology 1998
10779773 Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells

Rahn Landstrom, T, Quon, MJ, Manganiello, VC, Cong, LN, Stenson Holst, L, Ahmad, F, Degerman, E, Pierce, JH, Wang, LM

J. Immunol. 2000
10454575 Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt

Kitamura, Y, Ogawa, W, Kuroda, S, Kasuga, M, Matsuzaki, H, Ando, M, Kitamura, T, Kotani, K, Kikkawa, U, Konishi, H, Hino, Y

Mol Cell Biol 1999
22001403 From PDE3B to the regulation of energy homeostasis

Guirguis, E, Manganiello, V, Chung, YW, Degerman, E, Ahmad, F, Stenson, L, Omar, B

Curr Opin Pharmacol 2011
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T309,S474-AKT2:PIP3 [plasma membrane]

Physical Entity
p-T309,S474-AKT2:PIP3 [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Phosphorylation of PDE3B by AKT-1 (Mus musculus)
Created
de Bono, B  (2005-03-24)
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