Reactome | NCBP1 [cytosol]

NCBP1 [cytosol]

Stable Identifier

R-HSA-162459

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CBP80, 80 kDa nuclear cap binding protein (NCBP 80 kDa subunit) (CBP80), 80 kDa nuclear cap binding protein, NCBP 80 kDa subunit

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Metabolism of non-coding RNA (Homo sapiens)
  - snRNP Assembly (Homo sapiens)
    - Nuclear export of snRNA transcripts (Homo sapiens)
      - Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
      - Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
      - mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
      - mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Transport of Mature Transcript to Cytoplasm (Homo sapiens)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
      - Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
      - mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q09161 NCBP1

Gene Names

NCBP1, CBP80, NCBP

Chain

chain:1-790

Reference Genes

BioGPS Gene:4686 NCBP1

COSMIC (genes):NCBP1 NCBP1

CTD Gene:4686 NCBP1

dbSNP Gene:4686 NCBP1

ENSEMBL:ENSG00000136937 NCBP1

HGNC:7658 NCBP1

KEGG:hsa:4686 NCBP1

Monarch:4686 NCBP1

NCBI Gene:4686 NCBP1

OMIM:600469 NCBP1

UCSC:Q09161 NCBP1

Reference Transcript

RefSeq:NM_002486.4 NCBP1

Other Identifiers

11725977_at

11725978_at

17087343

209519_3p_at

209519_PM_at

209519_at

209520_PM_s_at

209520_s_at

3181303

3181304

3181307

3181308

3181310

3181311

3181312

3181313

3181314

3181315

3181316

3181318

3181320

3181321

3181322

3181323

3181325

3181326

3181327

3181329

3181330

3181331

3181332

3181333

3181334

3181335

3181336

3181337

3181338

3181339

3181340

3181341

3181342

3181343

3181344

3181345

3181346

37987_at

4686

53692_at

8156718

A_14_P113175

A_14_P116217

A_23_P257104

A_33_P3261192

A_33_P3261197

A_33_P3299854

D32002_s_at

GE79811

GO:0000184

GO:0000245

GO:0000339

GO:0000340

GO:0000380

GO:0000398

GO:0002191

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005846

GO:0006351

GO:0006355

GO:0006370

GO:0006401

GO:0006406

GO:0006408

GO:0006417

GO:0006446

GO:0006913

GO:0008334

GO:0008380

GO:0016070

GO:0016071

GO:0030307

GO:0031047

GO:0031053

GO:0031124

GO:0031442

GO:0032968

GO:0034518

GO:0035194

GO:0035195

GO:0042789

GO:0043226

GO:0048026

GO:0050684

GO:0051028

GO:0051607

GO:0060090

GO:0065003

GO:0098542

GO:1905216

GO:1990904

HMNXSV003009315

Hs.89563.0.S2_3p_at

Hs.89563.0.S2_3p_x_at

ILMN_1777528

PH_hs_0033442

TC09000492.hg

g12655186_3p_a_at

Participates

as a component of

Cap Binding Complex (CBC) [cytosol] (Homo sapiens)

Other forms of this molecule

NCBP1 [nucleoplasm]

Inferred To

Cbp80 [cytosol] (Drosophila melanogaster)

NCBP1 [cytosol] (Bos taurus)

NCBP1 [cytosol] (Canis familiaris)

NCBP1 [cytosol] (Gallus gallus)

NCBP1 [cytosol] (Sus scrofa)

cbc1 [cytosol] (Schizosaccharomyces pombe)

Ncbp1 [cytosol] (Mus musculus)

Ncbp1 [cytosol] (Rattus norvegicus)

STO1 [cytosol] (Saccharomyces cerevisiae)

ncbp1 [cytosol] (Dictyostelium discoideum)

ncbp1 [cytosol] (Xenopus tropicalis)

ncbp-1 [cytosol] (Caenorhabditis elegans)

Ghost homologue of NCBP1 [cytosol] (Danio rerio)

Ghost homologue of NCBP1 [cytosol] (Plasmodium falciparum)

Cross References

RefSeq

NP_002477.1

OpenTargets

ENSG00000136937

ENSEMBL

ENST00000375147, ENSP00000364289

HPA

ENSG00000136937-NCBP1

PRO

Q09161

Pharos - Targets

Q09161

GlyGen

Q09161

PDB

6D0Y, 1H2V, 1H2U, 1N54, 1N52, 1H2T, 7ABG, 3FEY, 8BY6, 5OOB, 1H6K, 3FEX, 8PMP, 5OO6, 8PNT

Interactors (56)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52298 NCBP2	2	NCBP2 [cytosol] (R-HSA-162458) NCBP2 [nucleoplasm] (R-HSA-51463)	0.965	54
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.872	14
UniProt:P52298-1 NCBP2			0.771	8
UniProt:Q9H814 PHAX	2	PHAX [cytosol] (R-HSA-191804) PHAX [nucleoplasm] (R-HSA-191803)	0.744	10
UniProt:O75150 RNF40	1	RNF40 [nucleoplasm] (R-HSA-5689015)	0.743	5
UniProt:Q53F19 NCBP3			0.716	11
UniProt:Q92900 UPF1	2	p-4S-UPF1 [cytosol] (R-HSA-927856) UPF1 [cytosol] (R-HSA-927734)	0.69	9
ChEBI:50210 7-METHYL-GTP			0.688	14
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.662	9
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.643	5
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.643	4
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.643	8
UniProt:Q86VM9 ZCH18			0.643	10
UniProt:P08621 SNRNP70	1	SNRNP70 [nucleoplasm] (R-HSA-71913)	0.643	6
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.643	3
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.643	3
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.576	3
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.564	2
UniProt:Q9BY77 POLDIP3	2	POLDIP3 [cytosol] (R-HSA-8850627) POLDIP3 [nucleoplasm] (R-HSA-8850646)	0.558	3
UniProt:Q5VTR2 RNF20	2	RNF20 [cytosol] (R-HSA-9715141) RNF20 [nucleoplasm] (R-HSA-5689011)	0.556	3
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.556	3
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.527	2
UniProt:Q9HCE1 MOV10	1	MOV10 [cytosol] (R-HSA-427772)	0.527	3
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.527	4
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.527	2
UniProt:Q9UHI6 DDX20	2	DDX20 [nucleoplasm] (R-HSA-191847) DDX20 [cytosol] (R-HSA-191838)	0.527	7
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.527	2
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.527	4
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	4
UniProt:Q8IYD1 GSPT2	1	GSPT2 [cytosol] (R-HSA-143379)	0.527	3
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.527	2
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.527	3
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	3
UniProt:Q86V81 ALYREF	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.527	3
UniProt:P26368 U2AF2	2	U2AF2 [nucleoplasm] (R-HSA-71987) 5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011)	0.527	3
UniProt:P42285 SKIV2L2	1	SKIV2L2 [nucleoplasm] (R-HSA-6791189)	0.527	6
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.527	3
UniProt:Q13838 DDX39B	2	DDX39B [nucleoplasm] (R-HSA-8849139) DDX39B [cytosol] (R-HSA-9715154)	0.527	6
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	4
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.527	2
UniProt:P18615 NELFE	2	NELFE [nucleoplasm] (R-HSA-62907) p-NELFE [nucleoplasm] (R-HSA-170698)	0.527	4
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	6
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	2
UniProt:P62316 SNRPD2	2	SNRPD2 [cytosol] (R-HSA-191810) SNRPD2 [nucleoplasm] (R-HSA-71901)	0.527	5
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.527	2
UniProt:Q86U42 PABPN1	2	PABPN1 [cytosol] (R-HSA-9822424) PABPN1 [nucleoplasm] (R-HSA-72008)	0.527	6
UniProt:Q8WX92 NELFB	3	NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [cytosol] (R-HSA-9603526) NELFB [nucleoplasm] (R-HSA-112427)	0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	4
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.527	6
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368) CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987)	0.527	3
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.527	2
UniProt:O95453 PARN	1	PARN [cytosol] (R-HSA-430009)	0.525	2
UniProt:P55884 EIF3B	1	EIF3B [cytosol] (R-HSA-72542)	0.462	8
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.462	2
UniProt:Q04637 EIF4G1	2	p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762) EIF4G1 [cytosol] (R-HSA-72584)	0.462	2