Inactivation of Myt1 kinase

Stable Identifier
R-HSA-162657
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Inactivation of Myt1 kinase
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At mitotic entry Plk1 phosphorylates and inhibits Myt1 activity. Cyclin B1-bound Cdc2, which is the target of Myt1, functions in a feedback loop and phosphorylates and further inhibits Myt1.

Literature References
PubMed ID Title Journal Year
12738781 Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate

Toyoshima-Morimoto, F, Nishida, E, Taniguchi, E, Nakajima, H

J Biol Chem 2003
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Event Information
Go Biological Process
regulation of cell cycle (0051726)
Catalyst Activity

protein serine/threonine kinase activity of p-T210-PLK1 [nucleoplasm]

Physical Entity
p-T210-PLK1 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Inactivation of Myt1 kinase (Bos taurus)
Inactivation of Myt1 kinase (Caenorhabditis elegans)
Inactivation of Myt1 kinase (Canis familiaris)
Inactivation of Myt1 kinase (Danio rerio)
Inactivation of Myt1 kinase (Dictyostelium discoideum)
Inactivation of Myt1 kinase (Drosophila melanogaster)
Inactivation of Myt1 kinase (Mus musculus)
Inactivation of Myt1 kinase (Rattus norvegicus)
Inactivation of Myt1 kinase (Saccharomyces cerevisiae)
Inactivation of Myt1 kinase (Schizosaccharomyces pombe)
Inactivation of Myt1 kinase (Sus scrofa)
Inactivation of Myt1 kinase (Xenopus tropicalis)
Authored
Lee, KS  (2004-12-09)
Created
Gillespie, ME  (2004-12-09)
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