glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH

Stable Identifier
R-HSA-162683
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In the fourth step of GPI synthesis, an acyl group (typically palmitate) is transferred from acyl CoA to glucosaminyl-PI. Mutagenesis and cloning studies suggest that a single protein, PIG-W, catalyzes this reaction (Murakami et al. 2003).
Literature References
PubMed ID Title Journal Year
14517336 PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor

Kinoshita, T, Murakami, Y, Nakakuma, H, Kang, JY, Ishihara, S, Hong, Y, Siripanyapinyo, U, Maeda, Y

Mol Biol Cell 2003
Participants
Input
Output
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as an event of
Catalyst Activity

O-acyltransferase activity of PIGW [endoplasmic reticulum membrane]

Physical Entity
PIGW [endoplasmic reticulum membrane] (Homo sapiens)
Activity
O-acyltransferase activity (GO:0008374)
Orthologous Events
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Bos taurus)
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Caenorhabditis elegans)
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Canis familiaris)
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Dictyostelium discoideum)
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Drosophila melanogaster)
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Gallus gallus)
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Mus musculus)
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Plasmodium falciparum)
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Rattus norvegicus)
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Saccharomyces cerevisiae)
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Schizosaccharomyces pombe)
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Sus scrofa)
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Xenopus tropicalis)
Authored
D'Eustachio, P  (2005-04-05)
Created
D'Eustachio, P  (2005-04-05)
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