Reactome | GPI-PLAUR [endoplasmic reticulum membrane]

GPI-PLAUR [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-162687

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

N-glycyl-glycosylphosphatidylinositolethanolamine-PLAUR, urokinase plasminogen activator receptor-acyl-GPI, uPAR-acyl-GPI

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External Reference Information

External Reference

UniProt:Q03405 PLAUR

Gene Names

PLAUR, MO3, UPAR

Chain

signal peptide:1-22, chain:23-305, propeptide:306-335

Reference Genes

BioGPS Gene:5329 PLAUR

COSMIC (genes):PLAUR PLAUR

CTD Gene:5329 PLAUR

dbSNP Gene:5329 PLAUR

ENSEMBL:ENSG00000011422 PLAUR

HGNC:9053 PLAUR

KEGG:hsa:5329 PLAUR

Monarch:5329 PLAUR

NCBI Gene:5329 PLAUR

OMIM:173391 PLAUR

UCSC:Q03405 PLAUR

Reference Transcript

Participates

as an input of

uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Homo sapiens)

as an output of

uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Homo sapiens)

Other forms of this molecule

GPI-PLAUR [specific granule membrane]

PLAUR [plasma membrane]

GPI-PLAUR [plasma membrane]

PLAUR(23-335) [endoplasmic reticulum membrane]

PLAUR(306-335) [endoplasmic reticulum lumen]

PLAUR [endoplasmic reticulum membrane]

Inferred To

Plaur [endoplasmic reticulum membrane] (Mus musculus)

Plaur [endoplasmic reticulum membrane] (Rattus norvegicus)

PLAUR [endoplasmic reticulum membrane] (Bos taurus)

GPI-PLAUR [endoplasmic reticulum membrane] (Canis familiaris)

GPI-PLAUR [endoplasmic reticulum membrane] (Sus scrofa)

Modified Residues

Name

glycine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 305

Coordinate

305

Modification

GPI-anchor amidated amino acid carboxyl end residue(1−)

PsiMod Name

glycine amide

PsiMod Definition

A protein modification that effectively converts a glycine residue to glycine amide.

Cross References

OpenTargets

ENSG00000011422

ENSEMBL

ENST00000340093, ENST00000221264, ENSP00000221264, ENSP00000339328, ENST00000339082, ENSP00000342049, ENSG00000011422

GeneCards

PLAUR

HPA

ENSG00000011422-PLAUR

ZINC - Substances

UPAR_HUMAN

ZINC target

Q03405

PRO

Q03405

Pharos - Targets

Q03405

GlyGen

Q03405

ZINC - Predictions - Purchasable

UPAR_HUMAN

PDB

7E17, 3U73, 2FD6, 3BT2, 4QTI, 3BT1, 4K24, 3U74, 2I9B, 1YWH, 7V63

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03950 ANG	2	ANG [extracellular region] (R-HSA-5692435) ANG [cytosol] (R-HSA-9708345)	0.571	5
UniProt:P00749 PLAU	6	PLAU(21-431) [tertiary granule membrane] (R-HSA-6800974) PLAU(21-431) [plasma membrane] (R-HSA-158945) PLAU(21-431) [specific granule membrane] (R-HSA-6799705) PLAU(21-431) [extracellular region] (R-HSA-158979) PLAU(179-431) [plasma membrane] (R-HSA-158970) PLAU(21-177) [plasma membrane] (R-HSA-158956)	0.564	3
UniProt:P51688 SGSH	5	SGSH R245H [lysosomal lumen] (R-HSA-2214347) SGSH C1091del [lysosomal lumen] (R-HSA-2214344) SGSH S66W [lysosomal lumen] (R-HSA-2214340) SGSH R74C [lysosomal lumen] (R-HSA-2214341) SGSH [lysosomal lumen] (R-HSA-1678689)	0.527	2
UniProt:Q92626 PXDN	1	PXDN [extracellular region] (R-HSA-2559628)	0.527	2
UniProt:Q8NBL1 POGLUT1	1	POGLUT1 [endoplasmic reticulum lumen] (R-HSA-1464796)	0.527	2
UniProt:Q86XF0 DHFR2	1	DHFR2 [cytosol] (R-HSA-2975816)	0.527	2
UniProt:Q93075 TATDN2	1	TATDN2 [nucleoplasm] (R-HSA-535508)	0.527	2
UniProt:Q09328 MGAT5	1	MGAT5 [Golgi membrane] (R-HSA-975896)	0.527	2
UniProt:Q9UBS3 DNAJB9	1	DNAJB9 [endoplasmic reticulum membrane] (R-HSA-381010)	0.527	2
UniProt:Q86X52 CHSY1	5	CHSY1 P539R [Golgi membrane] (R-HSA-3636862) CHSY1 E33Sfs2 [Golgi membrane] (R-HSA-3636864) CHSY1 Q69 [Golgi membrane] (R-HSA-3636838) CHSY1 G19_L28del [Golgi membrane] (R-HSA-3636823) CHSY1 [Golgi membrane] (R-HSA-1971431)	0.527	2
UniProt:Q5NDL2 EOGT			0.527	2
UniProt:Q13509 TUBB3	6	TUBB3 [cytosol] (R-HSA-190532) TUBB3 [axonemal microtubule] (R-HSA-5610436) Polyglutamyl-TUBB3 [cytosol] (R-HSA-8867464) Polyglycyl-TUBB3 [cytosol] (R-HSA-8867372) TUBB3 unfolded [cytosol] (R-HSA-392770) TUBB3 folding intermediate [cytosol] (R-HSA-392806)	0.527	2
UniProt:O43542 XRCC3	1	XRCC3 [nucleoplasm] (R-HSA-5685303)	0.527	2
UniProt:P52848 NDST1	1	NDST1 [Golgi membrane] (R-HSA-2022869)	0.527	2
UniProt:P52849 NDST2	1	NDST2 [Golgi membrane] (R-HSA-2022933)	0.527	2
UniProt:P15848 ARSB	12	ARSB [ficolin-1-rich granule lumen] (R-HSA-6800887) ARSB [extracellular region] (R-HSA-6806236) ARSB [azurophil granule lumen] (R-HSA-6798774) ARSB [endoplasmic reticulum lumen] (R-HSA-1614331) OxA-ARSB [endoplasmic reticulum lumen] (R-HSA-1614325) OxA-ARSB [lysosomal lumen] (R-HSA-1606837) ARSB H393P [lysosomal lumen] (R-HSA-5649492) ARSB R95Q [lysosomal lumen] (R-HSA-2314614) ARSB G144R [lysosomal lumen] (R-HSA-2314612) ARSB P116H [lysosomal lumen] (R-HSA-2314619) ARSB C117R [lysosomal lumen] (R-HSA-2314618) ARSB Y86del [lysosomal lumen] (R-HSA-2314606)	0.527	2
UniProt:Q9BTZ2 DHRS4	3	DHRS4 [cytosol] (R-HSA-9033122) DHRS4 [peroxisomal matrix] (R-HSA-9033097) DHRS4 [endoplasmic reticulum membrane] (R-HSA-2980897)	0.527	2
UniProt:Q8IVL6 P3H3	1	LEPREL2 [endoplasmic reticulum lumen] (R-HSA-1650821)	0.527	2
UniProt:Q14680 MELK			0.527	2
UniProt:O60921 HUS1	1	HUS1 [nucleoplasm] (R-HSA-176374)	0.527	2
UniProt:P15289 ARSA	9	ARSA(448-507) [azurophil granule lumen] (R-HSA-6798775) ARSA(19-444) [azurophil granule lumen] (R-HSA-6798776) ARSA(448-507) [extracellular region] (R-HSA-6806249) ARSA(19-444) [extracellular region] (R-HSA-6806192) ARSA(19-444) [endoplasmic reticulum lumen] (R-HSA-1614334) ARSA(448-507) [endoplasmic reticulum lumen] (R-HSA-1614307) OxA-ARSA(19-444) [endoplasmic reticulum lumen] (R-HSA-1614359) OxA-ARSA(19-444) [lysosomal lumen] (R-HSA-508497) ARSA(448-507) [lysosomal lumen] (R-HSA-1606798)	0.527	2
UniProt:Q8N3Y3 LARGE2	1	GYLTL1B [Golgi membrane] (R-HSA-5617136)	0.527	2
UniProt:Q9NXL9 MCM9			0.527	2
UniProt:Q92824 PCSK5	2	PCSK5(115-913) [Golgi lumen] (R-HSA-166558) PCSK5 [extracellular region] (R-HSA-6784682)	0.527	2
UniProt:P55268 LAMB2	3	LAMB2 [extracellular region] (R-HSA-215961) p-LAMB2 [endoplasmic reticulum lumen] (R-HSA-8957053) LAMB2 [endoplasmic reticulum lumen] (R-HSA-8956752)	0.527	2
UniProt:Q9Y4K0 LOXL2	3	LOXL2(26-?) [extracellular region] (R-HSA-2022106) LOXL2 [extracellular region] (R-HSA-2022142) LOXL2(?-774) [extracellular region] (R-HSA-2022136)	0.527	2
UniProt:Q70JA7 CHSY3	1	CHSY3 [Golgi membrane] (R-HSA-1971428)	0.527	2
UniProt:Q16706 MAN2A1	2	MAN2A1 [transport vesicle] (R-HSA-8847487) MAN2A1 [Golgi membrane] (R-HSA-975823)	0.527	3
UniProt:P33908 MAN1A1	2	MAN1A1 [transport vesicle] (R-HSA-8847488) MAN1A1 [Golgi membrane] (R-HSA-964767)	0.527	2
UniProt:Q8NAT1 POMGNT2	1	POMGNT2 [endoplasmic reticulum membrane] (R-HSA-8879119)	0.527	3
UniProt:Q6UWY0 ARSK	2	OxA-ARSK [endoplasmic reticulum lumen] (R-HSA-1614364) ARSK [endoplasmic reticulum lumen] (R-HSA-1609684)	0.527	2
UniProt:Q8TCG2 PI4K2B	1	PI4K2B [cytosol] (R-HSA-1604675)	0.527	2
UniProt:Q16394 EXT1	6	EXT1 R339L [Golgi membrane] (R-HSA-3730912) EXT1 L490Rfs9 [Golgi membrane] (R-HSA-3730975) EXT1 R340C [Golgi membrane] (R-HSA-3730974) EXT1 G339D [Golgi membrane] (R-HSA-3730910) EXT1 G198Afs54 [Golgi membrane] (R-HSA-3730971) EXT1 [Golgi membrane] (R-HSA-2022897)	0.527	2
UniProt:P34059 GALNS	6	GALNS G301C [lysosomal lumen] (R-HSA-2245324) GALNS R386C [lysosomal lumen] (R-HSA-2245326) GALNS I113F [lysosomal lumen] (R-HSA-2245331) OxA-GALNS [lysosomal lumen] (R-HSA-1630321) OxA-GALNS [extracellular region] (R-HSA-6806214) OxA-GALNS [azurophil granule lumen] (R-HSA-6799224)	0.527	3

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