Reactome | glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate

glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate

Stable Identifier

R-HSA-162830

Type

Reaction

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the fifth step of GPI synthesis, a mannose residue is added to glucosaminyl-acyl-PI. The reaction takes place at the lumenal surface of the endoplasmic reticulum membrane. It is catalyzed by a complex of at least two components, PIG-M and PIG-X (Maeda et al. 2001; Ashida et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15635094	Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I Kinoshita, T, Murakami, Y, Kim, YU, Hong, Y, Ashida, H, Maeda, Y, Sugimoto, N, Shishioh, N	Mol Biol Cell	2005
11226175	PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER Kinoshita, T, Watanabe, R, Ohishi, K, Hong, Y, Kinoshita, K, Harris, CL, Maeda, Y	EMBO J	2001