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PLAUR(23-335) [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-162866
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
urokinase plasminogen activator receptor precursor, uPAR precursor
Icon
Locations in the PathwayBrowser for interactor UniProt:P00749 PLAU
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Post-translational modification: synthesis of GPI-anchored proteins (Homo sapiens)
Attachment of GPI anchor to uPAR (Homo sapiens)
uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Homo sapiens)
PLAUR(23-335) [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q03405 PLAUR
Gene Names
PLAUR, MO3, UPAR
Chain
signal peptide:1-22, chain:23-305, propeptide:306-335
Reference Genes
BioGPS Gene:5329 PLAUR
COSMIC (genes):PLAUR PLAUR
CTD Gene:5329 PLAUR
dbSNP Gene:5329 PLAUR
ENSEMBL:ENSG00000011422 PLAUR
ENSEMBL_homo_sapiens_GENE:ENSG00000011422.12 PLAUR
HGNC:9053 PLAUR
KEGG Gene (Homo sapiens):5329 PLAUR
Monarch:5329 PLAUR
NCBI Gene:5329 PLAUR
OMIM:173391 PLAUR
UCSC:Q03405 PLAUR
Reference Transcript
RefSeq:NM_002659.3 PLAUR
RefSeq:NM_001005376.2 PLAUR
RefSeq:NM_001301037.1 PLAUR
RefSeq:NM_001005377.2 PLAUR
Other Identifiers
11738053_x_at
11742818_a_at
11742819_at
11743062_a_at
11743063_x_at
16873060
189_s_at
210845_PM_s_at
210845_s_at
211924_PM_s_at
211924_s_at
214866_PM_at
214866_at
3864552
3864553
3864554
3864558
3864559
3864560
3864563
3864564
3864565
3864566
3864576
3864577
3864578
3864584
3864585
41169_at
5329
8037374
A_23_P16469
GE80529
GO:0001934
GO:0005102
GO:0005515
GO:0005576
GO:0005783
GO:0005788
GO:0005789
GO:0005886
GO:0005925
GO:0006935
GO:0007005
GO:0007155
GO:0007165
GO:0007596
GO:0009897
GO:0009986
GO:0010755
GO:0012501
GO:0016020
GO:0019898
GO:0019899
GO:0019904
GO:0023052
GO:0030155
GO:0030162
GO:0030377
GO:0031410
GO:0034112
GO:0035579
GO:0036211
GO:0038023
GO:0038195
GO:0042060
GO:0042995
GO:0043066
GO:0043226
GO:0043388
GO:0045742
GO:0051604
GO:0051917
GO:0060089
GO:0070161
GO:0090200
GO:0098552
GO:0098637
GO:1905370
GO:2001243
GO:2001268
HMNXSV003001685
HMNXSV003015628
Hs.179657.2.S1_3p_at
ILMN_1691508
ILMN_2374340
ILMN_2408543
PH_hs_0032020
TC19001593.hg
U09937_rna1_s_at
X74039_at
g13641308_3p_s_at
g517197_3p_a_at
Participates
as an input of
uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Homo sapiens)
Other forms of this molecule
PLAUR [endoplasmic reticulum membrane]
GPI-PLAUR [endoplasmic reticulum membrane]
PLAUR(306-335) [endoplasmic reticulum lumen]
GPI-PLAUR [plasma membrane]
PLAUR [plasma membrane]
GPI-PLAUR [specific granule membrane]
Inferred To
Plaur [endoplasmic reticulum membrane]
(Mus musculus)
Plaur [endoplasmic reticulum membrane]
(Rattus norvegicus)
PLAUR [endoplasmic reticulum membrane]
(Bos taurus)
PLAUR(23-335) [endoplasmic reticulum membrane]
(Canis familiaris)
PLAUR(23-335) [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
RefSeq
NP_002650.1
,
NP_001005376.1
,
NP_001287966.1
,
NP_001005377.1
OpenTargets
ENSG00000011422
HPA
ENSG00000011422-PLAUR
GeneCards
Q03405
ZINC - Substances
UPAR_HUMAN
Ensembl
ENSG00000011422
,
ENSP00000342049
,
ENST00000339082
,
ENSP00000221264
,
ENST00000221264
,
ENSP00000339328
,
ENST00000340093
ZINC target
Q03405
PRO
Q03405
Pharos - Targets
Q03405
ZINC - Predictions - Purchasable
UPAR_HUMAN
PDB
1YWH
,
3U74
,
2FD6
,
7E17
,
2I9B
,
4QTI
,
3BT2
,
4K24
,
3U73
,
3BT1
,
7V63
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P03950 ANG
2
ANG [cytosol]
(R-HSA-9708345)
ANG [extracellular region]
(R-HSA-5692435)
0.571
5
UniProt:P00749 PLAU
6
PLAU(21-177) [plasma membrane]
(R-HSA-158956)
PLAU(179-431) [plasma membrane]
(R-HSA-158970)
PLAU(21-431) [extracellular region]
(R-HSA-158979)
PLAU(21-431) [specific granule membrane]
(R-HSA-6799705)
PLAU(21-431) [plasma membrane]
(R-HSA-158945)
PLAU(21-431) [tertiary granule membrane]
(R-HSA-6800974)
0.564
3
UniProt:P34059 GALNS
6
GALNS G301C [lysosomal lumen]
(R-HSA-2245324)
GALNS R386C [lysosomal lumen]
(R-HSA-2245326)
GALNS I113F [lysosomal lumen]
(R-HSA-2245331)
OxA-GALNS [lysosomal lumen]
(R-HSA-1630321)
OxA-GALNS [extracellular region]
(R-HSA-6806214)
OxA-GALNS [azurophil granule lumen]
(R-HSA-6799224)
0.527
3
UniProt:Q16394 EXT1
6
EXT1 R339L [Golgi membrane]
(R-HSA-3730912)
EXT1 L490Rfs*9 [Golgi membrane]
(R-HSA-3730975)
EXT1 R340C [Golgi membrane]
(R-HSA-3730974)
EXT1 G339D [Golgi membrane]
(R-HSA-3730910)
EXT1 G198Afs*54 [Golgi membrane]
(R-HSA-3730971)
EXT1 [Golgi membrane]
(R-HSA-2022897)
0.527
2
UniProt:Q8TCG2 PI4K2B
1
PI4K2B [cytosol]
(R-HSA-1604675)
0.527
2
UniProt:P51688 SGSH
5
SGSH R245H [lysosomal lumen]
(R-HSA-2214347)
SGSH C1091del [lysosomal lumen]
(R-HSA-2214344)
SGSH S66W [lysosomal lumen]
(R-HSA-2214340)
SGSH R74C [lysosomal lumen]
(R-HSA-2214341)
SGSH [lysosomal lumen]
(R-HSA-1678689)
0.527
2
UniProt:Q6UWY0 ARSK
2
OxA-ARSK [endoplasmic reticulum lumen]
(R-HSA-1614364)
ARSK [endoplasmic reticulum lumen]
(R-HSA-1609684)
0.527
2
UniProt:P33908 MAN1A1
2
MAN1A1 [transport vesicle]
(R-HSA-8847488)
MAN1A1 [Golgi membrane]
(R-HSA-964767)
0.527
2
UniProt:Q70JA7 CHSY3
1
CHSY3 [Golgi membrane]
(R-HSA-1971428)
0.527
2
UniProt:Q9Y4K0 LOXL2
3
LOXL2(26-?) [extracellular region]
(R-HSA-2022106)
LOXL2 [extracellular region]
(R-HSA-2022142)
LOXL2(?-774) [extracellular region]
(R-HSA-2022136)
0.527
2
UniProt:P55268 LAMB2
3
p-LAMB2 [endoplasmic reticulum lumen]
(R-HSA-8957053)
LAMB2 [endoplasmic reticulum lumen]
(R-HSA-8956752)
LAMB2 [extracellular region]
(R-HSA-215961)
0.527
2
UniProt:Q92626 PXDN
1
PXDN [extracellular region]
(R-HSA-2559628)
0.527
2
UniProt:Q9NXL9 MCM9
0.527
2
UniProt:Q8N3Y3 LARGE2
1
GYLTL1B [Golgi membrane]
(R-HSA-5617136)
0.527
2
UniProt:P15289 ARSA
9
ARSA(19-444) [extracellular region]
(R-HSA-6806192)
ARSA(448-507) [extracellular region]
(R-HSA-6806249)
ARSA(19-444) [azurophil granule lumen]
(R-HSA-6798776)
ARSA(448-507) [azurophil granule lumen]
(R-HSA-6798775)
ARSA(448-507) [lysosomal lumen]
(R-HSA-1606798)
OxA-ARSA(19-444) [lysosomal lumen]
(R-HSA-508497)
OxA-ARSA(19-444) [endoplasmic reticulum lumen]
(R-HSA-1614359)
ARSA(19-444) [endoplasmic reticulum lumen]
(R-HSA-1614334)
ARSA(448-507) [endoplasmic reticulum lumen]
(R-HSA-1614307)
0.527
2
UniProt:O60921 HUS1
1
HUS1 [nucleoplasm]
(R-HSA-176374)
0.527
2
UniProt:Q14680 MELK
0.527
2
UniProt:Q8IVL6 P3H3
1
LEPREL2 [endoplasmic reticulum lumen]
(R-HSA-1650821)
0.527
2
UniProt:Q9BTZ2 DHRS4
3
DHRS4 [endoplasmic reticulum membrane]
(R-HSA-2980897)
DHRS4 [peroxisomal matrix]
(R-HSA-9033097)
DHRS4 [cytosol]
(R-HSA-9033122)
0.527
2
UniProt:P15848 ARSB
12
ARSB Y86del [lysosomal lumen]
(R-HSA-2314606)
ARSB C117R [lysosomal lumen]
(R-HSA-2314618)
ARSB [endoplasmic reticulum lumen]
(R-HSA-1614331)
OxA-ARSB [endoplasmic reticulum lumen]
(R-HSA-1614325)
ARSB [azurophil granule lumen]
(R-HSA-6798774)
ARSB [extracellular region]
(R-HSA-6806236)
ARSB [ficolin-1-rich granule lumen]
(R-HSA-6800887)
OxA-ARSB [lysosomal lumen]
(R-HSA-1606837)
ARSB H393P [lysosomal lumen]
(R-HSA-5649492)
ARSB R95Q [lysosomal lumen]
(R-HSA-2314614)
ARSB G144R [lysosomal lumen]
(R-HSA-2314612)
ARSB P116H [lysosomal lumen]
(R-HSA-2314619)
0.527
2
UniProt:P52849 NDST2
1
NDST2 [Golgi membrane]
(R-HSA-2022933)
0.527
2
UniProt:P52848 NDST1
1
NDST1 [Golgi membrane]
(R-HSA-2022869)
0.527
2
UniProt:Q13509 TUBB3
6
TUBB3 folding intermediate [cytosol]
(R-HSA-392806)
TUBB3 unfolded [cytosol]
(R-HSA-392770)
Polyglycyl-TUBB3 [cytosol]
(R-HSA-8867372)
Polyglutamyl-TUBB3 [cytosol]
(R-HSA-8867464)
TUBB3 [axonemal microtubule]
(R-HSA-5610436)
TUBB3 [cytosol]
(R-HSA-190532)
0.527
2
UniProt:Q5NDL2 EOGT
0.527
2
UniProt:Q8NBL1 POGLUT1
1
POGLUT1 [endoplasmic reticulum lumen]
(R-HSA-1464796)
0.527
2
UniProt:Q93075 TATDN2
1
TATDN2 [nucleoplasm]
(R-HSA-535508)
0.527
2
UniProt:O43542 XRCC3
1
XRCC3 [nucleoplasm]
(R-HSA-5685303)
0.527
2
UniProt:Q16706 MAN2A1
2
MAN2A1 [transport vesicle]
(R-HSA-8847487)
MAN2A1 [Golgi membrane]
(R-HSA-975823)
0.527
3
UniProt:Q92824 PCSK5
2
PCSK5(115-913) [Golgi lumen]
(R-HSA-166558)
PCSK5 [extracellular region]
(R-HSA-6784682)
0.527
2
UniProt:Q8NAT1 POMGNT2
1
POMGNT2 [endoplasmic reticulum membrane]
(R-HSA-8879119)
0.527
3
UniProt:Q09328 MGAT5
1
MGAT5 [Golgi membrane]
(R-HSA-975896)
0.527
2
UniProt:Q86XF0 DHFR2
1
DHFR2 [cytosol]
(R-HSA-2975816)
0.527
2
UniProt:Q86X52 CHSY1
5
CHSY1 P539R [Golgi membrane]
(R-HSA-3636862)
CHSY1 E33Sfs*2 [Golgi membrane]
(R-HSA-3636864)
CHSY1 Q69* [Golgi membrane]
(R-HSA-3636838)
CHSY1 G19_L28del [Golgi membrane]
(R-HSA-3636823)
CHSY1 [Golgi membrane]
(R-HSA-1971431)
0.527
2
UniProt:Q9UBS3 DNAJB9
1
DNAJB9 [endoplasmic reticulum membrane]
(R-HSA-381010)
0.527
2
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