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ASH2L [nucleoplasm]
Stable Identifier
R-HSA-1629834
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Set1/Ash2 histone methyltransferase complex subunit ASH2, ASH2-like protein, ASH2L1
Icon
Locations in the PathwayBrowser for interactor UniProt:Q14686%20NCOA6
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
Formation of the RBBP5:ASH2L heterodimer (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Recruitment of SET1 methyltransferase complex (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBL3 ASH2L
Gene Names
ASH2L, ASH2L1
Chain
chain:1-628
Reference Genes
BioGPS Gene:9070 ASH2L
COSMIC (genes):ASH2L ASH2L
CTD Gene:9070 ASH2L
dbSNP Gene:9070 ASH2L
ENSEMBL:ENSG00000129691 ASH2L
ENSEMBL_homo_sapiens_GENE:ENSG00000129691.16 ASH2L
HGNC:744 ASH2L
KEGG Gene (Homo sapiens):9070 ASH2L
Monarch:9070 ASH2L
NCBI Gene:9070 ASH2L
OMIM:604782 ASH2L
UCSC:Q9UBL3 ASH2L
Reference Transcript
RefSeq:NM_001261832.1 ASH2L
RefSeq:NM_001105214.2 ASH2L
RefSeq:NM_004674.4 ASH2L
Other Identifiers
11739012_a_at
11739013_s_at
17067970
209517_PM_s_at
209517_s_at
3094448
3094449
3094450
3094451
3094452
3094453
3094457
3094458
3094460
3094462
3094465
3094466
3094468
3094469
3094472
3094473
3094474
3094476
3094480
3094481
3094482
3094483
3094484
35804_at
8145894
9070
A_14_P119074
A_23_P134827
GE54534
GO:0000791
GO:0000976
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006351
GO:0006355
GO:0006974
GO:0008013
GO:0008284
GO:0030097
GO:0030154
GO:0035097
GO:0036211
GO:0043226
GO:0043627
GO:0044665
GO:0044666
GO:0045815
GO:0045944
GO:0046872
GO:0048188
GO:0048856
GO:0051568
GO:0071339
HMNXSV003045628
ILMN_1666933
PH_hs_0000696
TC08000283.hg
g4417209_3p_a_at
Participates
as an input of
Formation of the RBBP5:ASH2L heterodimer (Homo sapiens)
Recruitment of SET1 methyltransferase complex (Homo sapiens)
as a component of
RBBP5:ASH2L [nucleoplasm] (Homo sapiens)
WRAD complex [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
as an output of
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
Inferred To
ash-2 [nucleoplasm]
(Caenorhabditis elegans)
Ash2l [nucleoplasm]
(Mus musculus)
Ash2l [nucleoplasm]
(Rattus norvegicus)
ash2l [nucleoplasm]
(Xenopus tropicalis)
ASH2L [nucleoplasm]
(Bos taurus)
ASH2L [nucleoplasm]
(Canis familiaris)
ASH2L [nucleoplasm]
(Dictyostelium discoideum)
ASH2L [nucleoplasm]
(Drosophila melanogaster)
ASH2L [nucleoplasm]
(Gallus gallus)
ASH2L [nucleoplasm]
(Plasmodium falciparum)
ASH2L [nucleoplasm]
(Saccharomyces cerevisiae)
ASH2L [nucleoplasm]
(Schizosaccharomyces pombe)
ASH2L [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001098684.1
,
NP_004665.2
,
NP_001248761.1
OpenTargets
ENSG00000129691
GeneCards
Q9UBL3
HPA
ENSG00000129691-ASH2L
Ensembl
ENST00000428278
,
ENSP00000340896
,
ENSP00000395310
,
ENSG00000129691
,
ENSP00000430259
,
ENST00000521652
,
ENST00000343823
PRO
Q9UBL3
Pharos - Targets
Q9UBL3
PDB
7W6L
,
7UD5
,
6KIZ
,
7MBM
,
6KIX
,
6PWV
,
7MBN
,
6KIW
,
7W67
,
6KIV
,
5F6L
,
6KIU
,
3TOJ
,
5F6K
,
6W5N
,
3S32
,
7BRE
,
7W6A
,
6W5M
,
3RSN
,
6W5I
,
4X8P
,
4RIQ
,
7W6I
,
4X8N
,
7W6J
,
6E2H
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15291 RBBP5
1
RBBP5 [nucleoplasm]
(R-HSA-1629836)
0.977
37
UniProt:Q9C005 DPY30
1
DPY30 [nucleoplasm]
(R-HSA-5669104)
0.965
22
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.942
15
UniProt:Q14686 NCOA6
1
NCOA6 [nucleoplasm]
(R-HSA-376414)
0.918
14
UniProt:Q03164 KMT2A
6
KMT2A [cytosol]
(R-HSA-9818584)
KMT2A(2719-3969) [cytosol]
(R-HSA-9818590)
KMT2A(1-2718) [cytosol]
(R-HSA-9818597)
KMT2A [nucleoplasm]
(R-HSA-1183223)
KMT2A(1-2718) [nucleoplasm]
(R-HSA-9818591)
KMT2A(2719-3969) [nucleoplasm]
(R-HSA-9818593)
0.845
8
UniProt:O14686 KMT2D
1
KMT2D [nucleoplasm]
(R-HSA-1183219)
0.812
9
UniProt:Q6ZW49 PAXIP1
1
PAXIP1 [nucleoplasm]
(R-HSA-5619395)
0.794
12
UniProt:Q8NEZ4 KMT2C
1
KMT2C [nucleoplasm]
(R-HSA-1183224)
0.773
5
UniProt:P51610 HCFC1
2
HCFC1 [nucleoplasm]
(R-HSA-1592209)
K48polyUb,K63polyUb-HCFC1 [nucleoplasm]
(R-HSA-5690821)
0.748
6
UniProt:Q9P0U4 CXXC1
1
CXXC1 [nucleoplasm]
(R-HSA-535610)
0.69
7
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.643
7
UniProt:Q6NZQ4 Paxip1
2
Paxip1 [nucleoplasm]
(R-MMU-5619398)
Paxip1 [nucleoplasm]
(R-MMU-5619395)
0.623
4
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.623
5
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.604
3
UniProt:Q9UMN6 KMT2B
5
KMT2B [cytosol]
(R-HSA-9818624)
KMT2B(2-2062) [cytosol]
(R-HSA-9818621)
KMT2B(2063-2715) [cytosol]
(R-HSA-9818626)
KMT2B(2063-2715) [nucleoplasm]
(R-HSA-9818623)
KMT2B(2-2062) [nucleoplasm]
(R-HSA-9818620)
0.597
3
UniProt:Q6UXN9 WDR82
1
WDR82 [nucleoplasm]
(R-HSA-9821474)
0.597
3
UniProt:O15550 KDM6A
1
KDM6A [nucleoplasm]
(R-HSA-4754224)
0.597
5
UniProt:O15047 SETD1A
1
SETD1A [nucleoplasm]
(R-HSA-3239027)
0.597
3
UniProt:O43823 AKAP8
0.576
3
UniProt:O75460-2 ERN1
0.556
3
UniProt:Q8TAP6 CEP76
1
CEP76 [cytosol]
(R-HSA-380281)
0.556
3
UniProt:P54652 HSPA2
2
HSPA2 [cytosol]
(R-HSA-3371408)
HSPA2 [nucleoplasm]
(R-HSA-912480)
0.556
3
UniProt:Q0VDC6 Q0VDC6
0.556
3
UniProt:Q14696 MESD
0.556
3
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.556
3
UniProt:Q12888 TP53BP1
3
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
TP53BP1 [nucleoplasm]
(R-HSA-61175)
0.536
2
UniProt:Q9H4Z2 ZNF335
1
ZNF335 [nucleoplasm]
(R-HSA-6810129)
0.532
3
UniProt:Q9UPS6 SETD1B
1
SETD1B [nucleoplasm]
(R-HSA-5244714)
0.527
2
UniProt:O15294 OGT
2
OGT [nucleoplasm]
(R-HSA-3321845)
OGT [cytosol]
(R-HSA-9687814)
0.527
2
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
4
UniProt:Q96ST3 SIN3A
2
SIN3A [nucleoplasm]
(R-HSA-351657)
monoSUMO1-SIN3A [nucleoplasm]
(R-HSA-4086071)
0.499
3
UniProt:Q9HCK8 CHD8
1
CHD8 [nucleoplasm]
(R-HSA-3221598)
0.499
2
UniProt:Q9BTK6 PAGR1
1
PAGR1 [nucleoplasm]
(R-HSA-5619374)
0.462
3
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