WDR5 [nucleoplasm]

Stable Identifier
R-HSA-1629838
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, BIG3
Icon
WDR5 [nucleoplasm] icon
WDR5 [nucleoplasm] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P61964 WDR5
Gene Names
WDR5, BIG3
Chain
initiator methionine:, chain:2-334
Reference Genes
BioGPS Gene:11091 WDR5
COSMIC (genes):WDR5 WDR5
CTD Gene:11091 WDR5
dbSNP Gene:11091 WDR5
ENSEMBL:ENSG00000196363 WDR5
HGNC:12757 WDR5
KEGG:hsa:11091 WDR5
Monarch:11091 WDR5
NCBI Gene:11091 WDR5
OMIM:609012 WDR5
UCSC:P61964 WDR5
Reference Transcript
Other Identifiers
11091
11718374_at
11718375_x_at
11718376_s_at
17090893
223308_PM_s_at
223308_s_at
225170_PM_at
225170_at
2724381
43017_at
43018_g_at
43410_at
43411_g_at
78481_at
8159111
89596_at
A_23_P32558
A_33_P3281323
A_33_P3292417
GE55545
GO:0000122
GO:0000123
GO:0001501
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005975
GO:0006094
GO:0006325
GO:0006355
GO:0006357
GO:0016740
GO:0035064
GO:0035097
GO:0042393
GO:0042800
GO:0043226
GO:0044545
GO:0044665
GO:0044666
GO:0045722
GO:0045815
GO:0045893
GO:0045995
GO:0048188
GO:0048856
GO:0051302
GO:0051726
GO:0071339
GO:0072686
GO:0090043
GO:0140096
GO:0140672
HMNXSV003051883
HMNXSV003057386
Hs.13889.0.S1_3p_at
Hs.13889.0.S1_3p_x_at
Hs.323518.0.S1_3p_s_at
ILMN_1726049
ILMN_1728626
ILMN_1737087
PH_hs_0028321
TC09000781.hg
Participates
as a member of
as a component of
as an input of
Inferred To
wdr5 [nucleoplasm] (Danio rerio)
wdr5 [nucleoplasm] (Dictyostelium discoideum)
wdr5 [nucleoplasm] (Xenopus tropicalis)
swd3 [nucleoplasm] (Schizosaccharomyces pombe)
Wdr5 [nucleoplasm] (Mus musculus)
Wdr5 [nucleoplasm] (Rattus norvegicus)
SWD3 [nucleoplasm] (Saccharomyces cerevisiae)
WDR5 [nucleoplasm] (Bos taurus)
WDR5 [nucleoplasm] (Canis familiaris)
WDR5 [nucleoplasm] (Gallus gallus)
WDR5 [nucleoplasm] (Sus scrofa)
wds [nucleoplasm] (Drosophila melanogaster)
wdr-5.1 [nucleoplasm] (Caenorhabditis elegans)
Cross References
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
GeneCards
HPA
ZINC - Substances
ZINC target
PRO
Pharos - Targets
GlyGen
ZINC - Predictions - Purchasable
PDB
2H14, 4QL1, 6DAK, 7AXU, 6OI0, 6UIK, 8E9F, 7BED, 4Y7R, 8X3R, 6UJL, 4ERY, 6U5Y, 7AXX, 6PWV, 2H9M, 6U8O, 7U9Y, 6UJJ, 6UOZ, 8BB4, 3UVM, 6D9X, 5EAP, 6KIV, 6UHY, 6U5M, 6OI3, 6E1Z, 7CFP, 6E1Y, 6UIF, 2H6K, 8F93, 6PGB, 4O45, 3UR4, 6PG8, 6E22, 4CY2, 8T5I, 3EG6, 5M23, 4IA9, 4CY1, 2CO0, 4A7J, 6KIX, 2H68, 6BYN, 6PWW, 7AXS, 6UFX, 4ES0, 4GMB, 8Q1N, 2H9N, 6DAS, 6PGC, 6U80, 8BB5, 2G99, 4EWR, 7UAS, 6PG5, 6DY7, 3UVL, 6UHZ, 8WXR, 6E23, 2CNX, 7BCY, 4ERZ, 6W5M, 6W5I, 4GM3, 5EAM, 8HMX, 7WVK, 8UJY, 6PG3, 4GM8, 3UVN, 6U8L, 8F1G, 5M25, 6DAI, 7DNO, 6KIZ, 6OI1, 6WJQ, 3N0E, 7MBM, 8BB2, 7MBN, 3PSL, 7JTO, 8DU4, 7AXP, 2H9P, 5VFC, 3UVK, 4GM9, 6PGD, 6UCS, 5EAR, 3UVO, 6PGE, 6KIU, 6U8B, 6W5N, 2H6Q, 8WXV, 7Q2J, 6OI2, 8WXQ, 6UJ4, 6PG9, 8WXX, 6PG4, 2H6N, 5SXM, 2H13, 7UD5, 3MXX, 3N0D, 6DAR, 8G3E, 7JTP, 6OFZ, 7AXQ, 2H9L, 6IAM, 2G9A, 3EMH, 8BB3, 8G3C, 4ERQ, 2GNQ, 6PGF, 6PG6, 6KIW, 8WXT, 5EAL, 3P4F, 8X3S, 7CFQ, 8WXU, 6DYA, 6PGA, 2O9K, 6PG7, 6UJH, 6U6W, 4ESG, 3SMR
Interactors (96)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q03164 KMT2A  6 0.959 17
 UniProt:Q15291 RBBP5  1 0.955 17
 UniProt:Q9UBL3 ASH2L  1 0.947 17
 UniProt:Q7Z3B3 KANSL1  1 0.942 14
 UniProt:Q9UMN6 KMT2B  5 0.932 10
 UniProt:Q14686 NCOA6  1 0.918 10
 UniProt:O14686 KMT2D  1 0.914 11
 UniProt:Q6ZW49 PAXIP1  1 0.899 11
 UniProt:Q9P0U4 CXXC1  1 0.855 8
 UniProt:Q9C005 DPY30  1 0.855 9
 UniProt:Q9NS73 MBIP  1 0.847 8
 UniProt:O15047 SETD1A  1 0.837 7
 UniProt:Q2QGD7 ZXDC      0.801 6
 UniProt:P54259 ATN1  1 0.798 6
 UniProt:Q9UPS6 SETD1B  1 0.788 5
 UniProt:Q99496 RNF2  1 0.788 7
 UniProt:Q8IWI9 MGA  1 0.788 5
 UniProt:Q03933 HSF2      0.781 7
 UniProt:O15550 KDM6A  1 0.773 7
 UniProt:Q8NEZ4 KMT2C  1 0.773 6
 UniProt:P51610 HCFC1  2 0.773 6
 UniProt:Q8NFC6 BOD1L1  1 0.773 5
 UniProt:Q6PEV8 F199X      0.742 5
 UniProt:P68431 HIST1H3G  20 0.74 11
 IntAct:EBI-15650351 H3TAIL      0.734 5
 UniProt:Q9H9L4 KANSL2  1 0.734 4
 UniProt:P58004 SESN2  1 0.725 4
 UniProt:O75461 E2F6  2 0.725 5
 UniProt:Q13547 HDAC1  2 0.725 4
 UniProt:Q9P2R6 RERE      0.725 5
 UniProt:Q96EZ8 MCRS1  1 0.725 4
 UniProt:Q9ULM3 YEATS2  1 0.725 5
 UniProt:Q96ES7 SGF29  1 0.725 4
 UniProt:Q9BTK6 PAGR1  1 0.725 5
 UniProt:Q8N488 RYBP  1 0.725 5
 UniProt:Q9Y5Z7 HCFC2  1 0.725 4
 UniProt:O75528 TADA3  1 0.725 4
 UniProt:Q9BYE7 PCGF6  1 0.725 5
 UniProt:O00255 MEN1  4 0.708 4
 UniProt:Q8IYH5 ZZZ3  1 0.708 4
 UniProt:P04637 TP53  20 0.69 5
 UniProt:Q9H7Z6 KAT8  1 0.69 5
 UniProt:Q9NS73-5 MBIP      0.666 4
 UniProt:P01106 MYC  2 0.65 3
 UniProt:Q92769 HDAC2  2 0.643 3
 UniProt:Q9BVI0 PHF20  2 0.643 3
 UniProt:Q9P2N6 KANSL3  1 0.643 4
 UniProt:Q6ZSY5 PPR3F      0.643 3
 UniProt:P19784 CSNK2A2  2 0.643 3
 UniProt:Q969R5 L3MBTL2  2 0.643 4
 UniProt:Q9H8E8 KAT14  1 0.643 3
 UniProt:Q9HCK8 CHD8  1 0.623 3
 UniProt:Q7Z434-1 MAVS      0.591 3
 UniProt:C0HLS1 OSCRI      0.591 6
 UniProt:O43823 AKAP8      0.576 3
 UniProt:Q9D1P2  1 0.564 2
 UniProt:O15151 MDM4  5 0.556 3
 UniProt:A7MD48 SRRM4      0.556 3
 UniProt:O76083-2 PDE9A      0.556 3
 UniProt:Q9Y4F3 MARF1      0.556 6
 UniProt:A2RRG2 A2RRG2      0.556 3
 UniProt:Q9Y5X4 NR2E3      0.556 5
 UniProt:Q9H891 Q9H891      0.556 3
 UniProt:Q14204 DYNC1H1  3 0.556 3
 UniProt:Q92794 KAT6A  3 0.556 4
 UniProt:Q9Y2D8 ADIP      0.556 3
 UniProt:P10074 TZAP      0.556 3
 UniProt:Q9UJX6 ANAPC2  2 0.556 3
 UniProt:Q6FHY5 Q6FHY5      0.556 3
 UniProt:Q86V38 Q86V38      0.556 3
 UniProt:Q96PG8 BBC3B      0.556 3
 UniProt:Q92876 KLK6      0.556 3
 UniProt:O00308 WWP2  1 0.556 3
 IntAct:EBI-15662162 H3-8      0.544 2
 UniProt:Q13185 CBX3  1 0.527 3
 UniProt:P68400 CSNK2A1  2 0.527 3
 UniProt:Q8IY57 YAF2  1 0.527 3
 UniProt:O15530 PDPK1  3 0.527 2
 UniProt:Q01658 DR1  1 0.527 2
 UniProt:P61513 RPL37A  1 0.527 2
 UniProt:O75478 TADA2A  1 0.527 2
 UniProt:Q06587 RING1  1 0.527 3
 UniProt:P49674 CSNK1E  2 0.527 2
 UniProt:Q6NZQ4 Paxip1  2 0.527 3
 UniProt:P83916 CBX1  1 0.527 2
 UniProt:O15294 OGT  2 0.527 3
 UniProt:Q92831 KAT2B  1 0.527 2
 UniProt:Q14186 TFDP1  1 0.527 3
 UniProt:Q6UXN9 WDR82  1 0.527 2
 UniProt:Q92830 KAT2A  1 0.527 2
 UniProt:Q96IK1 BOD1  1 0.527 2
 UniProt:Q9Y4K3 TRAF6  8 0.524 2
 UniProt:Q13114 TRAF3  4 0.524 2
 UniProt:Q9NYB0 TERF2IP  1 0.508 2
 UniProt:Q9WTL8 Arntl  7 0.508 2
 UniProt:Q9H4Z2 ZNF335  1 0.462 2
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