Reactome | SMC3 [nucleoplasm]

SMC3 [nucleoplasm]

Stable Identifier

R-HSA-163009

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Structural maintenance of chromosomes protein 3

Locations in the PathwayBrowser

Expand all

Reproduction (Homo sapiens)

- Meiosis (Homo sapiens)
  - Meiotic synapsis (Homo sapiens)
    - ATR Kinase is recruited to unsynapsed regions (Homo sapiens)
      - Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)
      - Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
        
        Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)
    - ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)
      - Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
        
        Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)
      - Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)
      - Unsynapsed chromatin with gamma-H2A.x [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)
    - BRCA1 is recruited to unsynapsed regions (Homo sapiens)
      - Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)
      - Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)
    - Formation of axial/lateral elements of Synaptonemal Complex (Homo sapiens)
      - Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)
      - Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)
    - Synapsis (Homo sapiens)
      - Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)
      - Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)
    - Telomeres cluster at the nuclear membrane (Homo sapiens)
      - Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)
      - Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        SMC3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UQE7 SMC3

Gene Names

SMC3, BAM, BMH, CSPG6, SMC3L1

Chain

chain:1-1217

Reference Genes

BioGPS Gene:9126 SMC3

COSMIC (genes):SMC3 SMC3

CTD Gene:9126 SMC3

dbSNP Gene:9126 SMC3

ENSEMBL:ENSG00000108055 SMC3

ENSEMBL_homo_sapiens_GENE:ENSG00000108055.11 SMC3

HGNC:2468 SMC3

KEGG Gene (Homo sapiens):9126 SMC3

Monarch:9126 SMC3

NCBI Gene:9126 SMC3

OMIM:606062 SMC3

UCSC:Q9UQE7 SMC3

Reference Transcript

RefSeq:NM_005445.3 SMC3

Other Identifiers

11725679_at

11725680_at

11758700_s_at

16709140

209257_PM_s_at

209257_s_at

209258_PM_s_at

209258_s_at

209259_PM_s_at

209259_s_at

2495747

2495751

2495753

3263792

3263795

3263796

3263797

3263799

3263800

3263801

3263802

3263803

3263804

3263805

3263806

3263807

3263809

3263810

3263811

3263813

3263815

3263816

3263817

3263818

3263820

3263822

3263823

3263824

3263825

3263827

3263828

3263830

3263832

3263834

3263835

3263836

3263837

34763_at

57506_at

7930422

9126

A_23_P138631

A_32_P15364

GE54158

GO:0000166

GO:0000228

GO:0000278

GO:0000775

GO:0000785

GO:0000800

GO:0003677

GO:0003682

GO:0003690

GO:0003774

GO:0003777

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0005856

GO:0006260

GO:0006275

GO:0006281

GO:0006974

GO:0007010

GO:0007049

GO:0007059

GO:0007062

GO:0007064

GO:0008092

GO:0008278

GO:0016363

GO:0016787

GO:0016887

GO:0019827

GO:0022414

GO:0030892

GO:0030893

GO:0034087

GO:0034089

GO:0036033

GO:0043226

GO:0046982

GO:0048487

GO:0051276

GO:0051301

GO:0051321

GO:0061775

GO:0070840

GO:0090307

GO:0097431

GO:0140013

GO:0140014

GO:0140097

GO:0140657

HMNXSV003015259

Hs.24485.0.A1_3p_a_at

Hs.24485.0.A2_3p_a_at

ILMN_1718807

ILMN_1869354

ILMN_2182348

PH_hs_0006787

PH_hs_0027602

TC10000802.hg

g3089367_3p_a_at

Participates

as a component of

Other forms of this molecule

SMC3 [cytosol]

2xAcK-SMC3 [cytosol]

2xAcK-SMC3 [chromosome]

2xAcK-SMC3 [chromosome, centromeric region]

2xAcK-SMC3 [nucleoplasm]

Inferred To

SMC3 [nucleoplasm] (Bos taurus)

SMC3 [nucleoplasm] (Canis familiaris)

SMC3 [nucleoplasm] (Dictyostelium discoideum)

SMC3 [nucleoplasm] (Drosophila melanogaster)

SMC3 [nucleoplasm] (Gallus gallus)

SMC3 [nucleoplasm] (Rattus norvegicus)

SMC3 [nucleoplasm] (Saccharomyces cerevisiae)

SMC3 [nucleoplasm] (Schizosaccharomyces pombe)

SMC3 [nucleoplasm] (Sus scrofa)

smc-3 [nucleoplasm] (Caenorhabditis elegans)

Structural maintenance of chromosomes protein 3 [nucleoplasm] (Mus musculus)

smc3 [nucleoplasm] (Danio rerio)

smc3 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_005436.1

OpenTargets

ENSG00000108055

HPA

ENSG00000108055-SMC3

GeneCards

Q9UQE7

Ensembl

ENST00000361804, ENSG00000108055, ENSP00000354720

PRO

Q9UQE7

Pharos - Targets

Q9UQE7

Orphanet

16795

PDB

6WG3, 6WGE, 6WG6, 6WG4, 7W1M

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60216 RAD21	14	monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) RAD21 [cytosol] (R-HSA-2484795) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21(173-450) [cytosol] (R-HSA-2500308) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) RAD21 [chromosome] (R-HSA-1638775) RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012)	0.956	18
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.822	13
UniProt:Q96FF9 CDCA5	6	p-S21,S75,T159-CDCA5 [chromosome] (R-HSA-2468266) p-S21,S75,T159-CDCA5 [cytosol] (R-HSA-2484804) p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (R-HSA-2468269) CDCA5 [chromosome] (R-HSA-2468149) CDCA5 [chromosome, centromeric region] (R-HSA-2468260) CDCA5 [nucleoplasm] (R-HSA-2466357)	0.744	6
UniProt:Q9CPY3	6	phospho-Cdca5 [chromosome] (R-MMU-2468266) phospho-Cdca5 [cytosol] (R-MMU-2484804) phospho-Cdca5 [chromosome, centromeric region] (R-MMU-2468269) Cdca5 [chromosome] (R-MMU-2468149) Cdca5 [chromosome, centromeric region] (R-MMU-2468260) Cdca5 [nucleoplasm] (R-MMU-2466357)	0.669	3
UniProt:Q61550 Rad21	15	Rad21 [nucleoplasm] (R-MMU-3108183) Double-strand-break repair protein rad21 homolog [nucleoplasm] (R-MMU-912350) phospho-Rad21 [cytosol] (R-MMU-2500310) phospho-Rad21 [chromosome] (R-MMU-2485164) Rad21 [cytosol] (R-MMU-2484795) phospho-Rad21 [cytosol] (R-MMU-2500309) Rad21 [cytosol] (R-MMU-2500308) Rad21 [cytosol] (R-MMU-2484901) Rad21 [chromosome, centromeric region] (R-MMU-2500296) phospho-Rad21 [chromosome, centromeric region] (R-MMU-2467790) Rad21 [chromosome, centromeric region] (R-MMU-2467793) phospho-Rad21 [chromosome, centromeric region] (R-MMU-2485163) Rad21 [chromosome] (R-MMU-1638775) Rad21 [chromosome, centromeric region] (R-MMU-2466012) Rad21 [nucleoplasm] (R-MMU-163042)	0.564	2
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.527	2
UniProt:Q92995 USP13	2	USP13 [nucleoplasm] (R-HSA-6781924) USP13 [cytosol] (R-HSA-6781893)	0.527	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.483	2

Cite Us!