Down Regulation of Emi1 through Phosphorylation of Emi1

Stable Identifier
R-HSA-163010
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Down Regulation of Emi1 through Phosphorylation of Emi1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
During the early stages of mitosis, Cdc2 and PLK1 cooperate to phosphorylate Emi1 and this modification induces Emi1 degradation through a Skp1-Cullin1 F-box protein (SCF) ubiquitin ligase-mediated proteolysis. Degradation of Emi1 permits activation of anaphase promoting complex and thereby the onset of anaphase.
Literature References
PubMed ID Title Journal Year
15148369 Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

Moshe, Y, Boulaire, J, Pagano, M, Hershko, A

Proc Natl Acad Sci U S A 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T210-PLK1 [nucleoplasm]

Physical Entity
p-T210-PLK1 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Down Regulation of Emi1 through Phosphorylation of Emi1 (Bos taurus)
Down Regulation of Emi1 through Phosphorylation of Emi1 (Canis familiaris)
Down Regulation of Emi1 through Phosphorylation of Emi1 (Danio rerio)
Down Regulation of Emi1 through Phosphorylation of Emi1 (Drosophila melanogaster)
Down Regulation of Emi1 through Phosphorylation of Emi1 (Gallus gallus)
Down Regulation of Emi1 through Phosphorylation of Emi1 (Mus musculus)
Down Regulation of Emi1 through Phosphorylation of Emi1 (Rattus norvegicus)
Down Regulation of Emi1 through Phosphorylation of Emi1 (Sus scrofa)
Down Regulation of Emi1 through Phosphorylation of Emi1 (Xenopus tropicalis)
Authored
Lee, KS  (2004-12-09)
Created
Gillespie, ME  (2005-04-12)
Cite Us!