Reactome | Down Regulation of Emi1 through Phosphorylation of Emi1

Down Regulation of Emi1 through Phosphorylation of Emi1

Stable Identifier

R-HSA-163010

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Down Regulation of Emi1 through Phosphorylation of Emi1

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During the early stages of mitosis, Cdc2 and PLK1 cooperate to phosphorylate Emi1 and this modification induces Emi1 degradation through a Skp1-Cullin1 F-box protein (SCF) ubiquitin ligase-mediated proteolysis. Degradation of Emi1 permits activation of anaphase promoting complex and thereby the onset of anaphase.

Literature References

PubMed ID	Title	Journal	Year
15148369	Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome Moshe, Y, Hershko, A, Pagano, M, Boulaire, J	Proc Natl Acad Sci U S A	2004