Reactome | STAG1 [nucleoplasm]

STAG1 [nucleoplasm]

Stable Identifier

R-HSA-163016

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SA1, Cohesin subunit SA-1, SCC3 homolog 1

Locations in the PathwayBrowser

Expand all

Reproduction (Homo sapiens)

- Meiosis (Homo sapiens)
  - Meiotic synapsis (Homo sapiens)
    - ATR Kinase is recruited to unsynapsed regions (Homo sapiens)
      - Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)
      - Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
        
        Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)
    - ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)
      - Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
        
        Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)
      - Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)
      - Unsynapsed chromatin with gamma-H2A.x [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)
    - BRCA1 is recruited to unsynapsed regions (Homo sapiens)
      - Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)
      - Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)
    - Formation of axial/lateral elements of Synaptonemal Complex (Homo sapiens)
      - Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)
      - Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)
    - Synapsis (Homo sapiens)
      - Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)
      - Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)
    - Telomeres cluster at the nuclear membrane (Homo sapiens)
      - Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)
      - Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WVM7 STAG1

Gene Names

STAG1, SA1, SCC3

Chain

chain:1-1258

Reference Genes

BioGPS Gene:10274 STAG1

COSMIC (genes):STAG1 STAG1

CTD Gene:10274 STAG1

dbSNP Gene:10274 STAG1

ENSEMBL:ENSG00000118007 STAG1

ENSEMBL_homo_sapiens_GENE:ENSG00000118007.13 STAG1

HGNC:11354 STAG1

KEGG Gene (Homo sapiens):10274 STAG1

Monarch:10274 STAG1

NCBI Gene:10274 STAG1

OMIM:604358 STAG1

UCSC:Q8WVM7 STAG1

Reference Transcript

RefSeq:NM_005862.2 STAG1

Other Identifiers

10274

11743276_s_at

11752130_a_at

11759484_s_at

16959531

202293_PM_at

202293_at

202294_PM_at

202294_at

2696803

2696804

2696807

2696808

2696810

2696811

2696814

2696817

2696818

2696820

2696822

2696823

2696825

2696830

2696834

2696835

2696836

2696837

2696838

2696842

2696844

2696849

2696852

2696853

2696854

2696857

2696860

2696861

2696870

2696875

2696878

2696895

2696896

2696899

2696901

2696902

2696923

2696924

2696925

39246_at

50041_at

59787_s_at

64351_at

64456_r_at

8090898

A_23_P357365

GE81569

GO:0000278

GO:0000775

GO:0000785

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0005856

GO:0007010

GO:0007049

GO:0007059

GO:0007062

GO:0008278

GO:0016363

GO:0016604

GO:0030892

GO:0034087

GO:0043226

GO:0051179

GO:0051301

GO:0090307

GO:0097431

GO:0140014

HMNXSV003013780

HMNXSV003027857

Hs.286148.0.S2_3p_at

Hs.286148.0.S3_3p_at

ILMN_1792435

ILMN_2151048

PH_hs_0022560

TC03001812.hg

Z75330_at

Participates

as a component of

Other forms of this molecule

STAG1 [cytosol]

STAG1 [chromosome]

STAG1 [chromosome, centromeric region]

Inferred To

psc3 [nucleoplasm] (Schizosaccharomyces pombe)

stag3 [nucleoplasm] (Xenopus tropicalis)

Homologues of STAG1 [nucleoplasm] (Drosophila melanogaster)

Homologues of STAG1 [nucleoplasm] (Schizosaccharomyces pombe)

Cohesin subunit SA-1 [nucleoplasm] (Mus musculus)

SA1 [nucleoplasm] (Drosophila melanogaster)

Stag1 [nucleoplasm] (Rattus norvegicus)

scc-3 [nucleoplasm] (Caenorhabditis elegans)

IRR1 [nucleoplasm] (Saccharomyces cerevisiae)

SA2 [nucleoplasm] (Drosophila melanogaster)

STAG1 [nucleoplasm] (Bos taurus)

STAG1 [nucleoplasm] (Canis familiaris)

STAG1 [nucleoplasm] (Dictyostelium discoideum)

STAG1 [nucleoplasm] (Gallus gallus)

STAG1 [nucleoplasm] (Sus scrofa)

rec11 [nucleoplasm] (Schizosaccharomyces pombe)

stag1b [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_005853.2

OpenTargets

ENSG00000118007

HPA

ENSG00000118007-STAG1

GeneCards

Q8WVM7

Ensembl

ENSG00000118007, ENSP00000236698, ENSP00000372689, ENST00000236698, ENST00000383202

PRO

Q8WVM7

Pharos - Targets

Q8WVM7

Orphanet

24949

PDB

5QSZ, 6R7O, 5QSV, 5QSR, 5QSN, 6RRC, 5QSQ, 5QSY, 5QSU, 5QSM, 6QB5, 5QSX, 5QST, 5QSP, 6WG3, 5QSS, 7W1M, 5QSW, 6RRK, 5QSO

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60216 RAD21	14	monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) RAD21 [cytosol] (R-HSA-2484795) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21(173-450) [cytosol] (R-HSA-2500308) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) RAD21 [chromosome] (R-HSA-1638775) RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012)	0.918	12
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.813	10
UniProt:Q61550 Rad21	15	Rad21 [nucleoplasm] (R-MMU-3108183) Double-strand-break repair protein rad21 homolog [nucleoplasm] (R-MMU-912350) phospho-Rad21 [cytosol] (R-MMU-2500310) phospho-Rad21 [chromosome] (R-MMU-2485164) Rad21 [cytosol] (R-MMU-2484795) phospho-Rad21 [cytosol] (R-MMU-2500309) Rad21 [cytosol] (R-MMU-2500308) Rad21 [cytosol] (R-MMU-2484901) Rad21 [chromosome, centromeric region] (R-MMU-2500296) phospho-Rad21 [chromosome, centromeric region] (R-MMU-2467790) Rad21 [chromosome, centromeric region] (R-MMU-2467793) phospho-Rad21 [chromosome, centromeric region] (R-MMU-2485163) Rad21 [chromosome] (R-MMU-1638775) Rad21 [chromosome, centromeric region] (R-MMU-2466012) Rad21 [nucleoplasm] (R-MMU-163042)	0.564	2
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.527	2
UniProt:Q9NZQ7 CD274	1	CD274 [plasma membrane] (R-HSA-3211776)	0.527	2
UniProt:P32249 GPR183	1	GPR183 [plasma membrane] (R-HSA-8851676)	0.527	3
UniProt:Q9NUP7 TRMT13	1	TRMT13 [cytoplasm] (R-HSA-6788716)	0.527	2
UniProt:Q96FF9 CDCA5	6	p-S21,S75,T159-CDCA5 [chromosome] (R-HSA-2468266) p-S21,S75,T159-CDCA5 [cytosol] (R-HSA-2484804) p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (R-HSA-2468269) CDCA5 [chromosome] (R-HSA-2468149) CDCA5 [chromosome, centromeric region] (R-HSA-2468260) CDCA5 [nucleoplasm] (R-HSA-2466357)	0.527	2

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