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TERT [nucleoplasm]
Stable Identifier
R-HSA-163076
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser for interactor UniProt:Q96BK5 PINX1
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
Biogenesis and assembly of the telomerase RNP (Homo sapiens)
TERT [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in DNA damage repair and senescence (Homo sapiens)
MITF-M-dependent TERT expression (Homo sapiens)
TERT [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Beta-catenin recruits SMARCA4 (Homo sapiens)
TERT [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14746 TERT
Gene Names
TERT, EST2, TCS1, TRT
Chain
chain:1-1132
Reference Genes
BioGPS Gene:7015 TERT
COSMIC (genes):TERT TERT
CTD Gene:7015 TERT
dbSNP Gene:7015 TERT
ENSEMBL:ENSG00000164362 TERT
ENSEMBL_homo_sapiens_GENE:ENSG00000164362.21 TERT
HGNC:11730 TERT
KEGG Gene (Homo sapiens):7015 TERT
Monarch:7015 TERT
NCBI Gene:7015 TERT
OMIM:187270 TERT
UCSC:O14746 TERT
Reference Transcript
RefSeq:NM_198253.2 TERT
RefSeq:NM_001193376.1 TERT
Other Identifiers
11730710_a_at
11752055_a_at
1555271_PM_a_at
1555271_a_at
16993919
1869_at
207199_PM_at
207199_at
2845830
2845831
2845834
2845837
2845839
2845840
2845843
2845844
2845845
2845848
2845850
2845854
2845855
2845856
2845857
2845860
2845861
2845862
2845863
2845866
2845867
2845868
2845869
2845870
2845871
2845872
2845873
2845874
2845875
2845876
2845877
2845878
7015
8110783
AF015950_at
GE80031
GO:0000049
GO:0000278
GO:0000333
GO:0000723
GO:0000781
GO:0000783
GO:0001172
GO:0001223
GO:0003677
GO:0003720
GO:0003721
GO:0003723
GO:0003824
GO:0003964
GO:0003968
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005697
GO:0005730
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006278
GO:0006351
GO:0006355
GO:0007004
GO:0007005
GO:0010629
GO:0012501
GO:0016605
GO:0016607
GO:0016740
GO:0016779
GO:0022616
GO:0023052
GO:0030154
GO:0030177
GO:0030422
GO:0031047
GO:0031379
GO:0031647
GO:0032092
GO:0032200
GO:0042162
GO:0042635
GO:0042645
GO:0042802
GO:0042803
GO:0043066
GO:0043226
GO:0043231
GO:0043524
GO:0045766
GO:0046326
GO:0046686
GO:0046872
GO:0048856
GO:0048870
GO:0051000
GO:0051087
GO:0055085
GO:0070034
GO:0070200
GO:0071456
GO:0071897
GO:0090399
GO:0098680
GO:0140097
GO:0140098
GO:0140745
GO:1900087
GO:1902895
GO:1903620
GO:1904707
GO:1904751
GO:1904754
GO:1990572
GO:1990904
GO:2000352
GO:2000648
GO:2000773
GO:2001240
HMNXSV003042277
Hs2.115256.2.S1_3p_s_at
ILMN_1796005
ILMN_2373119
PH_hs_0030270
TC05001105.hg
g4507438_3p_at
g4507438_3p_x_at
Participates
as an output of
MITF-M-dependent TERT expression (Homo sapiens)
as a component of
TCF/LEF:CTNNB1:SMARCA4:TERT [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
as an input of
Beta-catenin recruits SMARCA4 (Homo sapiens)
Biogenesis and assembly of the telomerase RNP (Homo sapiens)
Inferred To
TERT [nucleoplasm]
(Bos taurus)
TERT [nucleoplasm]
(Canis familiaris)
TERT [nucleoplasm]
(Dictyostelium discoideum)
TERT [nucleoplasm]
(Gallus gallus)
TERT [nucleoplasm]
(Mus musculus)
TERT [nucleoplasm]
(Plasmodium falciparum)
TERT [nucleoplasm]
(Rattus norvegicus)
TERT [nucleoplasm]
(Saccharomyces cerevisiae)
TERT [nucleoplasm]
(Schizosaccharomyces pombe)
TERT [nucleoplasm]
(Sus scrofa)
tert [nucleoplasm]
(Danio rerio)
Ghost homologue of TERT [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of TERT [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001180305.1
,
NP_937983.2
ZINC - World Drugs
TERT_HUMAN
OpenTargets
ENSG00000164362
ZINC - FDA approved
TERT_HUMAN
ZINC - Substances
TERT_HUMAN
ZINC target
O14746
ZINC - Biogenic
TERT_HUMAN
PRO
O14746
PDB
5MER
,
7TRE
,
4MNQ
,
5MEQ
,
5MEN
,
7QXS
,
7V99
,
7TRD
,
7QXB
,
5UGW
,
4B18
,
2BCK
,
7QXA
,
7BG9
,
5MEO
,
7TRF
,
5MEP
ZINC - Investigational
TERT_HUMAN
ZINC - Metabolites
TERT_HUMAN
GeneCards
O14746
HPA
ENSG00000164362-TERT
Ensembl
ENSG00000164362
,
ENST00000460137
,
ENSP00000309572
,
ENSP00000425003
,
ENST00000334602
,
ENSP00000334346
,
ENST00000310581
Pharos - Targets
O14746
ZINC - Predictions - Purchasable
TERT_HUMAN
Orphanet
16789
HMDB Protein
HMDBP02739
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-1772365 TERC
0.78
12
UniProt:O60832 DKC1
1
DKC1 [nucleoplasm]
(R-HSA-163102)
0.745
4
UniProt:P51532 SMARCA4
1
SMARCA4 [nucleoplasm]
(R-HSA-201686)
0.742
8
UniProt:Q96BK5 PINX1
0.677
6
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.644
11
UniProt:P03126 VE6
0.602
7
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.576
5
UniProt:O14746 TERT
1
TERT [nucleoplasm]
(R-HSA-163076)
0.561
3
IntAct:EBI-9875627 RMRP
0.558
7
UniProt:P29590-5 PML
0.556
7
UniProt:O14773-1 TPP1
0.544
2
UniProt:Q9BVP2 GNL3
1
GNL3 [nucleoplasm]
(R-HSA-8869324)
0.537
3
UniProt:Q92900 UPF1
2
UPF1 [cytosol]
(R-HSA-927734)
p-4S-UPF1 [cytosol]
(R-HSA-927856)
0.524
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.524
2
UniProt:P29590 PML
5
polySUMO3-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000386)
polySUMO2-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000423)
monoSUMO1-K65,160,490-PML [nucleoplasm]
(R-HSA-3000440)
PML [nucleoplasm]
(R-HSA-1031706)
PML [cytosol]
(R-HSA-5624327)
0.463
2
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