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DKC1 [nucleoplasm]
Stable Identifier
R-HSA-163102
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Dyskerin
Locations in the PathwayBrowser for interactor UniProt:Q9NY12 GAR1
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
Biogenesis and assembly of the telomerase RNP (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
DKC1 binds SHQ1 (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60832 DKC1
Gene Names
DKC1, NOLA4
Chain
initiator methionine:, chain:2-514
Reference Genes
BioGPS Gene:1736 DKC1
COSMIC (genes):DKC1 DKC1
CTD Gene:1736 DKC1
dbSNP Gene:1736 DKC1
ENSEMBL:ENSG00000130826 DKC1
ENSEMBL_homo_sapiens_GENE:ENSG00000130826.19 DKC1
HGNC:2890 DKC1
KEGG Gene (Homo sapiens):1736 DKC1
Monarch:1736 DKC1
NCBI Gene:1736 DKC1
OMIM:300126 DKC1
UCSC:O60832 DKC1
Reference Transcript
RefSeq:NM_001288747.1 DKC1
RefSeq:NM_001363.4 DKC1
RefSeq:NM_001142463.2 DKC1
Other Identifiers
11743467_at
11743468_at
17108500
1736
201478_PM_s_at
201478_s_at
201479_PM_at
201479_at
216212_PM_s_at
216212_s_at
34829_at
3996668
3996669
3996671
3996672
3996673
3996674
3996675
3996676
3996677
3996680
3996683
3996684
3996685
3996689
3996691
3996693
3996694
3996695
3996696
8170971
A_23_P137143
GE54597
GO:0000455
GO:0000495
GO:0001522
GO:0001650
GO:0003720
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005697
GO:0005730
GO:0005737
GO:0006364
GO:0006396
GO:0007004
GO:0009451
GO:0009982
GO:0015030
GO:0016071
GO:0016073
GO:0016740
GO:0016853
GO:0031118
GO:0031120
GO:0031429
GO:0032200
GO:0032212
GO:0033979
GO:0034513
GO:0042254
GO:0043226
GO:0051973
GO:0070034
GO:0072589
GO:0090661
GO:0090666
GO:0090669
GO:0140097
GO:1904851
GO:1904871
GO:1904872
GO:1904874
GO:1990481
GO:1990904
HMNXSV003016875
Hs.4747.1.S1_3p_a_at
ILMN_1671257
PH_hs_0000480
TC0X000779.hg
g2737893_3p_a_at
g4503336_3p_at
Participates
as a component of
Box H/ACA snoRNP [nucleoplasm] (Homo sapiens)
DKC1:SHQ1 [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
as an input of
DKC1 binds SHQ1 (Homo sapiens)
Biogenesis and assembly of the telomerase RNP (Homo sapiens)
Inferred To
cbf5 [nucleoplasm]
(Schizosaccharomyces pombe)
Nop60B [nucleoplasm]
(Drosophila melanogaster)
Dkc1 [nucleoplasm]
(Mus musculus)
Dkc1 [nucleoplasm]
(Rattus norvegicus)
nola4 [nucleoplasm]
(Dictyostelium discoideum)
DKC1 [nucleoplasm]
(Bos taurus)
DKC1 [nucleoplasm]
(Caenorhabditis elegans)
DKC1 [nucleoplasm]
(Canis familiaris)
DKC1 [nucleoplasm]
(Gallus gallus)
DKC1 [nucleoplasm]
(Plasmodium falciparum)
DKC1 [nucleoplasm]
(Sus scrofa)
CBF5 [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001135935.1
,
NP_001354.1
,
NP_001275676.1
OpenTargets
ENSG00000130826
HPA
ENSG00000130826-DKC1
GeneCards
O60832
Ensembl
ENSG00000130826
,
ENST00000369550
,
ENSP00000358563
PRO
O60832
Pharos - Targets
O60832
Orphanet
15869
PDB
7V9A
,
7BGB
,
8OUF
,
7TRC
,
8OUE
HMDB Protein
HMDBP01675
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96HR8 NAF1
0.9
12
UniProt:Q9NPE3 NOP10
1
NOP10 [nucleoplasm]
(R-HSA-6790665)
0.85
10
UniProt:Q9BUR4 WRAP53
2
WRAP53 [nucleoplasm]
(R-HSA-418386)
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
0.835
9
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.824
10
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.812
9
UniProt:Q9NY12 GAR1
1
GAR1 [nucleoplasm]
(R-HSA-6790707)
0.793
6
UniProt:O14746 TERT
1
TERT [nucleoplasm]
(R-HSA-163076)
0.745
4
UniProt:Q9NX24 NHP2
1
NHP2 [nucleoplasm]
(R-HSA-418325)
0.731
4
UniProt:Q6PI26 SHQ1
1
SHQ1 [nucleoplasm]
(R-HSA-9671152)
0.669
5
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.643
3
UniProt:Q9NX58 LYAR
0.564
3
UniProt:Q8WV16 DCAF4
1
DCAF4 [nucleoplasm]
(R-HSA-8955191)
0.527
4
UniProt:P42696 RBM34
0.527
2
UniProt:Q9NZM5 NOP53
0.527
3
UniProt:P50914 RPL14
1
RPL14 [cytosol]
(R-HSA-72414)
0.527
3
UniProt:P62241 RPS8
2
RPS8 [nucleoplasm]
(R-HSA-6791203)
RPS8 [cytosol]
(R-HSA-72385)
0.527
2
UniProt:Q8IXZ2 ZC3H3
0.527
2
UniProt:Q07020 RPL18
1
RPL18 [cytosol]
(R-HSA-72420)
0.527
2
UniProt:P46779 RPL28
1
RPL28 [cytosol]
(R-HSA-72444)
0.527
2
UniProt:P01127 PDGFB
8
PDGFB (82-190) [extracellular region]
(R-HSA-184201)
PDGFB(82-241) [extracellular region]
(R-HSA-381904)
PDGFB(1-241) [endoplasmic reticulum lumen]
(R-HSA-381903)
PDGFB(1-241) [Golgi membrane]
(R-HSA-380740)
PDGFB(1-81) [Golgi lumen]
(R-HSA-389058)
PDGFB(191-241) [Golgi lumen]
(R-HSA-396945)
PDGFB(21-81) [platelet alpha granule lumen]
(R-HSA-184200)
PDGFB(82-241) [platelet alpha granule lumen]
(R-HSA-387075)
0.527
2
UniProt:P06276 BCHE
2
BCHE [extracellular region]
(R-HSA-434469)
BCHE [plasma membrane]
(R-HSA-3640835)
0.527
2
UniProt:Q8TBF4 ZCRB1
2
ZCRB1 [cytosol]
(R-HSA-9682010)
ZCRB1 [nucleoplasm]
(R-HSA-6787853)
0.527
2
UniProt:P10412 H1-4
1
HIST1H1E [nucleoplasm]
(R-HSA-211251)
0.527
2
UniProt:P22492 H1T
0.527
3
UniProt:Q9NQZ8 ZNF71
1
ZNF71 [nucleoplasm]
(R-HSA-2454145)
0.527
2
UniProt:P08865 RPSA
2
RPSA [nucleoplasm]
(R-HSA-6798722)
RPSA [cytosol]
(R-HSA-72389)
0.527
2
UniProt:P08621 SNRNP70
1
SNRNP70 [nucleoplasm]
(R-HSA-71913)
0.527
4
UniProt:Q13247 SRSF6
1
SRSF6 [nucleoplasm]
(R-HSA-72026)
0.527
3
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.527
3
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.527
3
UniProt:Q6NT76 HMBX1
0.499
2
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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