Reactome | POLRMT [mitochondrial matrix]

POLRMT [mitochondrial matrix]

Stable Identifier

R-HSA-163267

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

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External Reference Information

External Reference

UniProt:O00411 POLRMT

Gene Names

POLRMT

Chain

transit peptide:1-41, chain:42-1230

Reference Genes

BioGPS Gene:5442 POLRMT

COSMIC (genes):POLRMT POLRMT

CTD Gene:5442 POLRMT

dbSNP Gene:5442 POLRMT

ENSEMBL:ENSG00000099821 POLRMT

HGNC:9200 POLRMT

Monarch:5442 POLRMT

NCBI Gene:5442 POLRMT

OMIM:601778 POLRMT

UCSC:O00411 POLRMT

Reference Transcript

RefSeq:NM_005035.3 POLRMT

Other Identifiers

11724889_a_at

11724890_x_at

11724891_s_at

16866456

17121810

203782_PM_s_at

203782_s_at

203783_PM_x_at

203783_x_at

3587287

3615781

3765796

3765798

3765800

3765801

3765803

3765804

3765805

3765806

3765809

3765811

3765812

3765813

3765814

3765815

3765817

3765818

3765820

3844655

3844657

3844658

3844659

3844660

3844661

3844662

3844663

3844664

3844665

3844667

3844668

3844669

3844670

3844671

3844672

3844675

3844678

3844679

3844680

3844681

3844682

3844683

3844684

3844685

3844686

3844687

3844688

3844689

3844690

3844691

3844692

3844693

3844694

3844695

3853636

3853648

3853652

40232_at

5442

8032057

A_23_P131096

GE59398

GE63286

GE86681

GO:0000175

GO:0000428

GO:0001018

GO:0003677

GO:0003723

GO:0003824

GO:0003896

GO:0003899

GO:0005515

GO:0005739

GO:0005759

GO:0006269

GO:0006351

GO:0006390

GO:0006391

GO:0016740

GO:0016779

GO:0016787

GO:0032991

GO:0034062

GO:0034245

GO:0042645

GO:0043226

GO:0043565

GO:0140098

HMNXSV003015487

Hs.153880.0.S1_3p_a_at

ILMN_1770356

PH_hs_0032336

TC19000987.hg

U75370_at

g4826925_3p_a_at

p8109

Participates

as an output of

as a component of

as an input of

POLRMT and POLG bind the mitochondrial L strand replication origin (OriL) (Homo sapiens)

Inferred To

polrmt [mitochondrial matrix] (Xenopus tropicalis)

rpo41 [mitochondrial matrix] (Schizosaccharomyces pombe)

Polrmt [mitochondrial matrix] (Mus musculus)

Polrmt [mitochondrial matrix] (Rattus norvegicus)

rpmA [mitochondrial matrix] (Dictyostelium discoideum)

rpom-1 [mitochondrial matrix] (Caenorhabditis elegans)

PolrMT [mitochondrial matrix] (Drosophila melanogaster)

POLRMT [mitochondrial matrix] (Bos taurus)

POLRMT [mitochondrial matrix] (Canis familiaris)

POLRMT [mitochondrial matrix] (Gallus gallus)

POLRMT [mitochondrial matrix] (Plasmodium falciparum)

POLRMT [mitochondrial matrix] (Sus scrofa)

RPO41 [mitochondrial matrix] (Saccharomyces cerevisiae)

Cross References

ENSEMBL

ENST00000588649, ENSP00000465759

OpenTargets

ENSG00000099821

HPA

ENSG00000099821-POLRMT

PRO

O00411

Pharos - Targets

O00411

HMDB Protein

HMDBP00742

PDB

6ERP, 7ZC4, 5OLA, 6ERQ, 7PZP, 3SPA, 7A8P, 4BOC, 7PZR

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52815 MRPL12	2	MRPL12 [mitochondrial inner membrane] (R-HSA-5368256) MRPL12 [mitochondrial matrix] (R-HSA-9839674)	0.748	7
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.669	3
UniProt:Q9H5Q4 TFB2M	1	TFB2M [mitochondrial matrix] (R-HSA-163272)	0.669	3
UniProt:Q00059 TFAM	3	TFAM [mitochondrial matrix] (R-HSA-163312) TFAM(1-246) [cytosol] (R-HSA-1592203) p-S55,S56,S61,S160-TFAM [mitochondrial matrix] (R-HSA-9838277)	0.564	2
UniProt:Q96QE5 TEFM			0.558	6
UniProt:Q96DN2 VWCE			0.527	2
UniProt:Q9UF02 CCG5			0.527	2
UniProt:Q7L7V1 DHX32			0.527	2
UniProt:Q9Y240 CLC11			0.527	3
UniProt:Q99435 NELL2	1	NELL2 [extracellular region] (R-HSA-9010198)	0.527	2
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.527	2

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