Reactome | p-AMBRA1 [cytosol]

p-AMBRA1 [cytosol]

Stable Identifier

R-HSA-1632854

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Activating molecule in BECN1-regulated autophagy protein 1, AMRA1_HUMAN, AMBRA1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9C0C7 AMBRA1

Gene Names

AMBRA1, DCAF3, KIAA1736

Chain

chain:1-1298

Reference Genes

BioGPS Gene:55626 AMBRA1

COSMIC (genes):AMBRA1 AMBRA1

CTD Gene:55626 AMBRA1

dbSNP Gene:55626 AMBRA1

ENSEMBL:ENSG00000110497 AMBRA1

HGNC:25990 AMBRA1

KEGG:hsa:55626 AMBRA1

Monarch:55626 AMBRA1

NCBI Gene:55626 AMBRA1

OMIM:611359 AMBRA1

UCSC:Q9C0C7 AMBRA1

Reference Transcript

Participates

as an output of

BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Homo sapiens)

as a component of

p-AMBRA1:DYNLL1,DYNLL2 [cytosol] (Homo sapiens)

Other forms of this molecule

AMBRA1 [cytosol]

Inferred To

phospho-AMBRA1 [cytosol] (Bos taurus)

phospho-AMBRA1 [cytosol] (Canis familiaris)

phospho-AMBRA1 [cytosol] (Sus scrofa)

phospho-Ambra1 [cytosol] (Mus musculus)

phospho-Ambra1 [cytosol] (Rattus norvegicus)

phospho-ambra1 [cytosol] (Xenopus tropicalis)

Ghost homologue of p-AMBRA1 [cytosol] (Caenorhabditis elegans)

Ghost homologue of p-AMBRA1 [cytosol] (Drosophila melanogaster)

Ghost homologue of p-AMBRA1 [cytosol] (Gallus gallus)

Ghost homologue of p-AMBRA1 [cytosol] (Schizosaccharomyces pombe)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

XP_005253071.1, XP_006718322.1, NP_060219.2, XP_005253068.1, XP_005253066.1, NP_001287660.1, NP_001254712.1, NP_001254711.1

OpenTargets

ENSG00000110497

ENSEMBL

ENST00000528950, ENST00000314845, ENSP00000433945, ENSP00000415327, ENST00000683756, ENSG00000110497, ENSP00000431926, ENST00000458649, ENSP00000508322, ENST00000534300, ENSP00000318313

HPA

ENSG00000110497-AMBRA1

GeneCards

AMBRA1

PRO

Q9C0C7

Pharos - Targets

Q9C0C7

GlyGen

Q9C0C7

PDB

8WQR

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.868	9
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.659	10
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [recycling endosome] (R-HSA-8854761)	0.641	3
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.638	3
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.638	3
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.591	3
UniProt:P12504 VIF			0.558	5
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.527	2
UniProt:Q9BW61 DDA1	1	DDA1 [nucleoplasm] (R-HSA-8863297)	0.527	3
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.508	2

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