Reactome | ULK1 phosphorylates AMBRA1:BECN1 complex

ULK1 phosphorylates AMBRA1:BECN1 complex

Stable Identifier

R-HSA-1632857

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ULK1 phosphorylates AMBRA1:BECN1 complex

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Upon autophagy induction, ULK1 phosphorylates AMBRA1, which leads to the release of the Beclin-1 complex from the dynein motor complex (Di Bartolomeo et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20921139	The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy Pagliarini, V, D'Amelio, M, Romagnoli, A, Matteoni, S, Piacentini, M, Nardacci, R, Di Bartolomeo, S, Cecconi, F, Giunta, L, Fimia, GM, Lisi, G, Nazio, F, Corazzari, M, Antonioli, M, Oliverio, S, Fuoco, C	J Cell Biol	2010

Participants

Input

Output

Participates

as an event of

Macroautophagy (Homo sapiens)

Catalyst Activity

protein serine/threonine kinase activity of p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane]

Physical Entity

p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)

Activity

protein serine/threonine kinase activity (GO:0004674)

Orthologous Events

ULK1 phosphorylates AMBRA1:BECN1 complex (Bos taurus)

ULK1 phosphorylates AMBRA1:BECN1 complex (Caenorhabditis elegans)

ULK1 phosphorylates AMBRA1:BECN1 complex (Canis familiaris)

ULK1 phosphorylates AMBRA1:BECN1 complex (Drosophila melanogaster)

ULK1 phosphorylates AMBRA1:BECN1 complex (Gallus gallus)

ULK1 phosphorylates AMBRA1:BECN1 complex (Mus musculus)

ULK1 phosphorylates AMBRA1:BECN1 complex (Rattus norvegicus)