PKA-mediated phosphorylation of key metabolic factors

Stable Identifier
R-HSA-163358
DOI
10.3180/R-HSA-163358.6
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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PKA-mediated phosphorylation of key metabolic factors
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Upon dissociation of protein kinase A (PKA) tetramers in the presence of cAMP, the released PKA catalytic monomers phosphorylate specific serine and threonine residues of several metabolic enzymes. These target enzymes include glycogen phosphorylase kinase, glycogen synthase and PF2K-Pase. PKA also phosphorylates ChREBP (Carbohydrate Response Element Binding Protein), preventing its movement into the nucleus and thus its function as a positive transcription factor for genes involved in glycolytic and lipogenic reactions.
Literature References
PubMed ID Title Journal Year
12721358 A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis

Veech, RL

Proc Natl Acad Sci U S A 2003
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Event Information
Go Biological Process
protein kinase A signaling (0010737)
Orthologous Events
PKA-mediated phosphorylation of key metabolic factors (Caenorhabditis elegans)
PKA-mediated phosphorylation of key metabolic factors (Canis familiaris)
PKA-mediated phosphorylation of key metabolic factors (Drosophila melanogaster)
PKA-mediated phosphorylation of key metabolic factors (Rattus norvegicus)
PKA-mediated phosphorylation of key metabolic factors (Sus scrofa)
Authored
Gopinathrao, G  (2005-05-13)
Created
Gopinathrao, G  (2005-04-28)
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