Reactome | PPP1CC [cytosol]

PPP1CC [cytosol]

Stable Identifier

R-HSA-163443

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP1CC, Serine/threonine protein phosphatase PP1-gamma catalytic subunit , PP-1G

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External Reference Information

External Reference

UniProt:P36873 PPP1CC

Gene Names

PPP1CC

Chain

initiator methionine:, chain:2-323

Reference Genes

BioGPS Gene:5501 PPP1CC

COSMIC (genes):PPP1CC PPP1CC

CTD Gene:5501 PPP1CC

dbSNP Gene:5501 PPP1CC

ENSEMBL:ENSG00000186298 PPP1CC

HGNC:9283 PPP1CC

KEGG:hsa:5501 PPP1CC

Monarch:5501 PPP1CC

NCBI Gene:5501 PPP1CC

OMIM:176914 PPP1CC

UCSC:P36873 PPP1CC

Reference Transcript

Participates

as a component of

as an input of

FIRRM binds PPP1CC (Homo sapiens)

as a member of

Inferred To

PPP1CC [cytosol] (Bos taurus)

PPP1CC [cytosol] (Canis familiaris)

PPP1CC [cytosol] (Dictyostelium discoideum)

PPP1CC [cytosol] (Drosophila melanogaster)

PPP1CC [cytosol] (Gallus gallus)

PPP1CC [cytosol] (Plasmodium falciparum)

PPP1CC [cytosol] (Rattus norvegicus)

PPP1CC [cytosol] (Saccharomyces cerevisiae)

PPP1CC [cytosol] (Schizosaccharomyces pombe)

PPP1CC [cytosol] (Sus scrofa)

PPP1CC [cytosol] (Xenopus tropicalis)

pph-1 [cytosol] (Caenorhabditis elegans)

Ppp1cc [cytosol] (Mus musculus)

Homologues of PPP1CC [cytosol] (Plasmodium falciparum)

Cross References

RefSeq

NP_002701.1, NP_001231903.1

OpenTargets

ENSG00000186298

ENSEMBL

ENSP00000341779, ENSG00000186298, ENSP00000335084, ENST00000340766, ENST00000335007

ZINC - Substances

PP1G_HUMAN

ZINC - Biogenic

PP1G_HUMAN

ZINC target

P36873

PRO

P36873

GlyGen

P36873

PDB

1IT6, 4UT2, 2BCD, 4UT3, 8B5R, 1JK7, 2BDX, 1U32, 7SD0, 5INB, 5J28

GeneCards

PPP1CC

HPA

ENSG00000186298-PPP1CC

Pharos - Targets

P36873

ZINC - Predictions - Purchasable

PP1G_HUMAN

HMDB Protein

HMDBP01893

Interactors (71)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.884	11
UniProt:O94763 RMP			0.88	20
UniProt:P41236 IPP2			0.867	10
UniProt:Q15435 PP1R7			0.857	9
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.852	10
UniProt:Q14684 RRP1B			0.838	12
UniProt:Q9H175 CSRN2			0.831	9
UniProt:Q96SB3 NEB2			0.816	8
UniProt:Q8IWU2 LMTK2			0.813	8
UniProt:O60927 PP1RB			0.812	9
UniProt:O95405 ZFYVE9			0.801	8
UniProt:Q96KQ4 PPP1R13B	1	PPP1R13B [nucleoplasm] (R-HSA-6799775)	0.773	10
UniProt:Q12972 PPP1R8	1	PPP1R8 [nucleoplasm] (R-HSA-9770253)	0.745	7
UniProt:Q96MX6 DAA10			0.745	7
UniProt:Q96QC0 PP1RA			0.745	7
UniProt:Q9NUG6 PDRG1			0.745	7
UniProt:Q5SWA1 PR15B			0.695	5
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.69	6
UniProt:P49750 YLPM1			0.671	6
UniProt:A6NKD9 CC85C			0.671	6
UniProt:Q02833 RASF7			0.671	5
UniProt:Q9UHV9 PFDN2	1	PFDN2 [cytosol] (R-HSA-379544)	0.671	4
UniProt:Q5UIP0 RIF1	1	RIF1 [nucleoplasm] (R-HSA-480742)	0.671	6
UniProt:Q15834 CC85B			0.671	5
UniProt:P46013 KI67			0.671	5
UniProt:Q69YH5 CDCA2			0.671	6
UniProt:Q9H6T3 RPAP3			0.671	6
UniProt:Q96RT1 ERBIN	1	ERBIN [plasma membrane] (R-HSA-1358718)	0.671	6
UniProt:Q9H792 PEAK1	1	PEAK1 [cytosol] (R-HSA-9715162)	0.671	6
UniProt:Q86XI6 PPR3B			0.666	5
UniProt:Q9UQK1 PPP1R3C	2	K48polyUb-PPP1R3C [cytosol] (R-HSA-3781005) PPP1R3C [cytosol] (R-HSA-3777102)	0.666	4
UniProt:Q96S65 CSRN1			0.666	4
UniProt:Q6ZMQ8 LMTK1			0.659	3
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.643	6
UniProt:Q9ULJ8 NEB1			0.643	5
UniProt:Q9GZN8 ADSSP			0.643	5
UniProt:Q9NWS0 PIHD1			0.643	5
UniProt:Q8NG31 KNL1	2	CASC5 [nucleoplasm] (R-HSA-606296) CASC5 [cytosol] (R-HSA-375322)	0.59	4
UniProt:O94842 TOX4			0.569	3
UniProt:O15212 PFDN6	1	PFDN6 [cytosol] (R-HSA-379547)	0.569	3
UniProt:Q9UKX7 NUP50	1	NUP50 [nucleoplasm] (R-HSA-157740)	0.569	3
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.569	3
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.569	5
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.569	3
UniProt:Q6UXN9 WDR82	1	WDR82 [nucleoplasm] (R-HSA-9821474)	0.569	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.564	3
UniProt:Q4KMQ1-2 TPRN			0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q7Z5V6-2 SAXO4			0.556	3
UniProt:Q96I34 PP16A			0.556	3
UniProt:Q9UEG4 ZN629			0.556	3
UniProt:Q6NXS1 IPP2B			0.556	5
UniProt:Q12972-2 PPP1R8			0.556	3
UniProt:O95400 CD2BP2	1	CD2BP2 [nucleoplasm] (R-HSA-72054)	0.556	3
UniProt:O14990 IPP2C			0.556	3
UniProt:Q13625-3 TP53BP2			0.556	3
UniProt:Q8N912 NRAC			0.556	3
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.528	3
UniProt:Q8NHQ8 RASF8			0.527	3
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.527	4
UniProt:Q9UQ13 SHOC2	4	SHOC2 [cytosol] (R-HSA-9658444) SHOC2 M173I [cytosol] (R-HSA-9660486) SHOC2 Q269_H270delinsHY [cytosol] (R-HSA-9660464) SHOC2 S2G [cytosol] (R-HSA-9660457)	0.527	3
UniProt:Q8NI77 KIF18A	1	KIF18A [cytosol] (R-HSA-376239)	0.527	4
UniProt:P61353 RPL27	1	RPL27 [cytosol] (R-HSA-72440)	0.527	2
UniProt:Q6NYC8 PPR18			0.527	4
UniProt:Q6PJW8 CNST			0.527	4
UniProt:Q4KMQ1 TPRN	1	TPRN [cytosol] (R-HSA-9663023)	0.527	4
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.524	2
UniProt:O08785 Clock	6	p-T451,T461-Clock [nucleoplasm] (R-MMU-9920668) Clock [cytosol] (R-MMU-508720) p-T451,T461-Clock [cytosol] (R-MMU-9920658) p-S-Clock [nucleoplasm] (R-MMU-508670) p-T451,T461,S440,S441,S446-Clock [nucleoplasm] (R-MMU-9920662) p-S,T451,T461,S440,S441,S446-Clock [nucleoplasm] (R-MMU-9927976)	0.508	2
UniProt:O94763-1 URI1			0.499	8
UniProt:O15294 OGT	2	OGT [cytosol] (R-HSA-9687814) OGT [nucleoplasm] (R-HSA-3321845)	0.499	11
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2