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PPP1CC [cytosol]
Stable Identifier
R-HSA-163443
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PP1CC, Serine/threonine protein phosphatase PP1-gamma catalytic subunit , PP-1G
Icon
Locations in the PathwayBrowser for interactor UniProt:Q8NHQ8 RASF8
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
FIRRM binds PPP1CC (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
PPP1CC dephosphorylates PLK1 (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36873 PPP1CC
Gene Names
PPP1CC
Chain
initiator methionine:, chain:2-323
Reference Genes
BioGPS Gene:5501 PPP1CC
COSMIC (genes):PPP1CC PPP1CC
CTD Gene:5501 PPP1CC
dbSNP Gene:5501 PPP1CC
ENSEMBL:ENSG00000186298 PPP1CC
HGNC:9283 PPP1CC
KEGG:hsa:5501 PPP1CC
Monarch:5501 PPP1CC
NCBI Gene:5501 PPP1CC
OMIM:176914 PPP1CC
UCSC:P36873 PPP1CC
Reference Transcript
RefSeq:NM_001244974.2 PPP1CC
RefSeq:NM_002710.4 PPP1CC
Participates
as a component of
PP1 [cytosol] (Homo sapiens)
FIRRM:PPP1CC [cytosol] (Homo sapiens)
GADD34:PP1CC [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
as an input of
FIRRM binds PPP1CC (Homo sapiens)
as a member of
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
Inferred To
PPP1CC [cytosol]
(Bos taurus)
PPP1CC [cytosol]
(Canis familiaris)
PPP1CC [cytosol]
(Gallus gallus)
PPP1CC [cytosol]
(Plasmodium falciparum)
PPP1CC [cytosol]
(Sus scrofa)
ppp1cc [cytosol]
(Xenopus tropicalis)
GLC7 [cytosol]
(Saccharomyces cerevisiae)
pph-1 [cytosol]
(Caenorhabditis elegans)
dis2 [cytosol]
(Schizosaccharomyces pombe)
Ppp1cc [cytosol]
(Mus musculus)
Ppp1cc [cytosol]
(Rattus norvegicus)
Pp1alpha-96A [cytosol]
(Drosophila melanogaster)
Homologues of PPP1CC [cytosol]
(Plasmodium falciparum)
pppB [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_002701.1
,
NP_001231903.1
ZINC - World Drugs
PP1G_HUMAN
OpenTargets
ENSG00000186298
ENSEMBL
ENSG00000186298
,
ENST00000340766
,
ENSP00000335084
,
ENSP00000341779
,
ENST00000335007
ZINC - Substances
PP1G_HUMAN
ZINC - Biogenic
PP1G_HUMAN
ZINC target
P36873
PRO
P36873
GlyGen
P36873
PDB
8B5R
,
5INB
,
1U32
,
1JK7
,
2BDX
,
4UT2
,
2BCD
,
7SD0
,
4UT3
,
1IT6
,
5J28
GeneCards
PPP1CC
HPA
ENSG00000186298-PPP1CC
Pharos - Targets
P36873
ZINC - Predictions - Purchasable
PP1G_HUMAN
HMDB Protein
HMDBP01893
Interactors (87)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13625 TP53BP2
1
TP53BP2 [nucleoplasm]
(R-HSA-6799780)
0.915
12
UniProt:O94763 RMP
0.912
21
UniProt:P41236 IPP2
0.901
11
UniProt:Q15435 PP1R7
0.894
10
UniProt:Q14684 RRP1B
0.876
13
UniProt:Q96SB3 NEB2
0.859
9
UniProt:Q8IWU2 LMTK2
0.856
9
UniProt:O60927 PP1RB
0.855
10
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.852
10
UniProt:O95405 ZFYVE9
0.847
9
UniProt:Q9H175 CSRN2
0.831
9
UniProt:Q96KQ4 PPP1R13B
1
PPP1R13B [nucleoplasm]
(R-HSA-6799775)
0.823
11
UniProt:Q12972 PPP1R8
1
PPP1R8 [nucleoplasm]
(R-HSA-9770253)
0.802
8
UniProt:Q96MX6 DAA10
0.802
8
UniProt:Q96QC0 PP1RA
0.802
8
UniProt:Q9NUG6 PDRG1
0.802
8
UniProt:Q96RT1 ERBIN
1
ERBIN [plasma membrane]
(R-HSA-1358718)
0.745
7
UniProt:Q5UIP0 RIF1
1
RIF1 [nucleoplasm]
(R-HSA-480742)
0.745
7
UniProt:P49750 YLPM1
0.745
7
UniProt:A6NKD9 CC85C
0.745
7
UniProt:Q02833 RASF7
0.745
6
UniProt:Q15834 CC85B
0.745
6
UniProt:P46013 KI67
0.745
6
UniProt:Q69YH5 CDCA2
0.745
7
UniProt:Q9H6T3 RPAP3
0.745
7
UniProt:Q9H792 PEAK1
1
PEAK1 [cytosol]
(R-HSA-9715162)
0.745
7
UniProt:Q96S65 CSRN1
0.742
5
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.725
7
UniProt:Q9ULJ8 NEB1
0.725
6
UniProt:Q9GZN8 ADSSP
0.725
6
UniProt:Q9NWS0 PIHD1
0.725
6
UniProt:Q5SWA1 PR15B
0.695
5
UniProt:Q8WUF5 PPP1R13L
1
PPP1R13L [nucleoplasm]
(R-HSA-6799738)
0.69
6
UniProt:Q8NG31 KNL1
2
CASC5 [nucleoplasm]
(R-HSA-606296)
CASC5 [cytosol]
(R-HSA-375322)
0.688
5
UniProt:Q9UHV9 PFDN2
1
PFDN2 [cytosol]
(R-HSA-379544)
0.671
4
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.671
6
UniProt:Q86XI6 PPR3B
0.666
5
UniProt:Q9UQK1 PPP1R3C
2
K48polyUb-PPP1R3C [cytosol]
(R-HSA-3781005)
PPP1R3C [cytosol]
(R-HSA-3777102)
0.666
4
UniProt:Q6ZMQ8 LMTK1
0.659
3
UniProt:Q8NHQ8 RASF8
0.643
4
UniProt:Q9UQ13 SHOC2
4
SHOC2 [cytosol]
(R-HSA-9658444)
SHOC2 M173I [cytosol]
(R-HSA-9660486)
SHOC2 Q269_H270delinsHY [cytosol]
(R-HSA-9660464)
SHOC2 S2G [cytosol]
(R-HSA-9660457)
0.643
4
UniProt:Q6NYC8 PPR18
0.643
5
UniProt:Q6PJW8 CNST
0.643
5
UniProt:Q4KMQ1 TPRN
1
TPRN [cytosol]
(R-HSA-9663023)
0.643
5
UniProt:Q8NI77 KIF18A
1
KIF18A [cytosol]
(R-HSA-376239)
0.643
5
UniProt:O94842 TOX4
0.569
3
UniProt:O15212 PFDN6
1
PFDN6 [cytosol]
(R-HSA-379547)
0.569
3
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.569
3
UniProt:Q9UKX7 NUP50
1
NUP50 [nucleoplasm]
(R-HSA-157740)
0.569
3
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.569
3
UniProt:Q6UXN9 WDR82
1
WDR82 [nucleoplasm]
(R-HSA-9821474)
0.569
3
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.564
3
UniProt:Q4KMQ1-2 TPRN
0.556
3
UniProt:Q05BL1 Q05BL1
0.556
3
UniProt:Q7Z5V6-2 SAXO4
0.556
3
UniProt:Q96I34 PP16A
0.556
3
UniProt:Q9UEG4 ZN629
0.556
3
UniProt:Q6NXS1 IPP2B
0.556
5
UniProt:Q12972-2 PPP1R8
0.556
3
UniProt:O95400 CD2BP2
1
CD2BP2 [nucleoplasm]
(R-HSA-72054)
0.556
3
UniProt:O14990 IPP2C
0.556
3
UniProt:Q13625-3 TP53BP2
0.556
3
UniProt:Q8N912 NRAC
0.556
3
UniProt:P62280 RPS11
2
RPS11 [cytosol]
(R-HSA-72327)
RPS11 [nucleoplasm]
(R-HSA-6791212)
0.528
3
UniProt:Q7Z3T8 ZFYVE16
1
ZFYVE16 [early endosome membrane]
(R-HSA-201645)
0.527
4
UniProt:P62140 PPP1CB
4
PPP1CB [cytosol]
(R-HSA-163405)
PPP1CB [nucleoplasm]
(R-HSA-62003)
PPP1CB P49R [cytosol]
(R-HSA-9660547)
PPP1CB A56P [cytosol]
(R-HSA-9660543)
0.527
4
UniProt:O95229 ZWINT
1
ZWINT [cytosol]
(R-HSA-376254)
0.527
3
UniProt:Q7Z5Y7 KCD20
0.527
2
UniProt:Q96EK5 KBP
0.527
4
UniProt:O14802 POLR3A
2
POLR3A [cytosol]
(R-HSA-1964433)
POLR3A [nucleoplasm]
(R-HSA-83700)
0.527
3
UniProt:P61353 RPL27
1
RPL27 [cytosol]
(R-HSA-72440)
0.527
2
UniProt:Q9H410 DSN1
3
DSN1 [cytosol]
(R-HSA-375308)
DSN1 [azurophil granule lumen]
(R-HSA-6799218)
DSN1 [extracellular region]
(R-HSA-6806228)
0.527
3
UniProt:Q8N350 CBARP
0.527
2
UniProt:Q96PV6 LENG8
0.527
2
UniProt:Q9UPR0 PLCL2
0.527
3
UniProt:Q9HCD5 NCOA5
0.527
2
UniProt:Q9P2K8 EIF2AK4
2
EIF2AK4 [cytosol]
(R-HSA-9633007)
p-T899-EIF2AK4 [cytosol]
(R-HSA-9633781)
0.527
4
UniProt:Q9BTT6 LRRC1
1
LRRC1 [cytosol]
(R-HSA-9715190)
0.527
3
UniProt:Q9HCD6 TANC2
0.527
4
UniProt:Q8IZ21 PHAR4
0.527
3
UniProt:Q8IXW5 RPAP2
1
RPAP2 [nucleoplasm]
(R-HSA-6810227)
0.527
2
UniProt:Q9Y2W2 WBP11
1
WBP11 [nucleoplasm]
(R-HSA-8867887)
0.527
2
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.524
2
UniProt:O08785 Clock
6
p-T451,T461-Clock [nucleoplasm]
(R-MMU-9920668)
Clock [cytosol]
(R-MMU-508720)
p-T451,T461-Clock [cytosol]
(R-MMU-9920658)
p-S-Clock [nucleoplasm]
(R-MMU-508670)
p-T451,T461,S440,S441,S446-Clock [nucleoplasm]
(R-MMU-9920662)
p-S,T451,T461,S440,S441,S446-Clock [nucleoplasm]
(R-MMU-9927976)
0.508
2
UniProt:O94763-1 URI1
0.499
8
UniProt:O15294 OGT
2
OGT [cytosol]
(R-HSA-9687814)
OGT [nucleoplasm]
(R-HSA-3321845)
0.499
11
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.483
2
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