Reactome | PPP1CA [cytosol]

PPP1CA [cytosol]

Stable Identifier

R-HSA-163525

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP1CA, Serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit , PP-1A

Locations in the PathwayBrowser for interactor UniProt:P19388 POLR2E

Expand all

External Reference Information

External Reference

UniProt:P62136 PPP1CA

Gene Names

PPP1CA, PPP1A

Chain

initiator methionine:1, chain:2-330

Reference Genes

BioGPS Gene:5499 PPP1CA

COSMIC (genes):PPP1CA PPP1CA

CTD Gene:5499 PPP1CA

dbSNP Gene:5499 PPP1CA

ENSEMBL:ENSG00000172531.16 PPP1CA

HGNC:9281 PPP1CA

KEGG Gene (Homo sapiens):5499 PPP1CA

Monarch:5499 PPP1CA

NCBI Gene:5499 PPP1CA

OMIM:176875 PPP1CA

UCSC:P62136 PPP1CA

Reference Transcript

Other Identifiers

0006290129

11737907_s_at

11754633_x_at

16740977

200846_PM_s_at

200846_s_at

32157_at

3378791

3378792

3378794

3378795

3378797

3378799

3378800

3378801

3378802

3378804

3378805

5499

74577_s_at

7949765

954_s_at

A_23_P434710

GO:0000164

GO:0000781

GO:0004721

GO:0004722

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0005886

GO:0005912

GO:0005975

GO:0005977

GO:0005979

GO:0005981

GO:0006091

GO:0006470

GO:0007049

GO:0007155

GO:0008157

GO:0010288

GO:0012501

GO:0016311

GO:0016787

GO:0016791

GO:0017018

GO:0023052

GO:0030324

GO:0032091

GO:0032922

GO:0032991

GO:0035970

GO:0036211

GO:0036496

GO:0042587

GO:0042752

GO:0043005

GO:0043021

GO:0043025

GO:0043153

GO:0043197

GO:0043204

GO:0043226

GO:0044877

GO:0046872

GO:0048754

GO:0048856

GO:0051301

GO:0060828

GO:0070062

GO:0070262

GO:0072357

GO:0098609

GO:0098631

GO:0098641

GO:0098793

GO:0098794

GO:0098978

GO:0140096

GO:1904886

GO:2001241

ILMN_1695827

ILMN_2377980

PH_hs_0010846

TC11001981.hg

g4506002_3p_a_at

Participates

as an input of

DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Homo sapiens)

as a component of

PP1A(Fe and Mn cofactors) [cytosol] (Homo sapiens)

as a member of

PP1 catalytic subunit [cytosol] (Homo sapiens)

Inferred To

ppp1cc [cytosol] (Danio rerio)

PPP1CA [cytosol] (Bos taurus)

PPP1CA [cytosol] (Canis familiaris)

PPP1CA [cytosol] (Mus musculus)

PPP1CA [cytosol] (Rattus norvegicus)

PPP1CA [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_002699.1, NP_001008709.1, NP_996756.1

OpenTargets

ENSG00000172531

IntEnz

3.1.3.16

GeneCards

P62136

HPA

ENSG00000172531-PPP1CA

ZINC target

P62136

Ensembl

ENST00000358239, ENSP00000365936, ENSP00000350974, ENSG00000172531, ENST00000312989, ENST00000376745, ENSP00000326031

PRO

P62136

Pharos - Targets

P62136

HMDB Protein

HMDBP08684

PDB

4MOV, 6OBQ, 6DNO, 4MP0, 4MOY, 6ZEF, 6OBR, 6ZK6, 6ZEG, 3EGH, 6OBN, 4XPN, 6ALZ, 6OBP, 4G9J, 6ZEE, 6CZO, 3N5U, 5IOH, 6G0J, 3EGG, 6DCX, 6ZEI, 3E7B, 6ZEH, 3HVQ, 6OBS, 3E7A, 6ZEJ, 6GHM, 3V4Y, 6G0I, 6OBU

Interactors (113)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41236 IPP2			0.948	12
UniProt:Q96KQ4 PPP1R13B	1	PPP1R13B [nucleoplasm] (R-HSA-6799775)	0.931	11
UniProt:Q12972 PPP1R8	1	PPP1R8 [nucleoplasm] (R-HSA-9770253)	0.902	8
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.889	9
UniProt:Q9H175 CSRN2			0.885	10
UniProt:Q96SB3 NEB2			0.857	6
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.857	9
UniProt:Q15435 PP1R7			0.836	8
UniProt:Q96S65 CSRN1			0.831	8
UniProt:O75807 PPP1R15A	1	PPP1R15A [cytosol] (R-HSA-178231)	0.819	12
UniProt:O35274 NEB2			0.813	8
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.807	7
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.796	5
UniProt:O75864 PPR37			0.783	5
UniProt:Q5SWA1 PR15B			0.772	5
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.771	5
UniProt:Q6NYC8 PPR18			0.758	5
UniProt:Q5UIP0 RIF1	1	RIF1 [nucleoplasm] (R-HSA-480742)	0.758	5
UniProt:Q9NWS0 PIHD1			0.75	5
UniProt:P13807 GYS1	3	GYS1 R462* [cytosol] (R-HSA-3828056) GYS1 [cytosol] (R-HSA-71565) p-S-GYS1 [cytosol] (R-HSA-71570)	0.75	5
UniProt:Q9NUG6 PDRG1			0.75	5
UniProt:O60927 PP1RB			0.75	5
UniProt:Q96MX6 DAA10			0.75	5
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.75	5
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.75	5
UniProt:Q9UQK1 PPP1R3C	2	K48polyUb-PPP1R3C [cytosol] (R-HSA-3781005) PPP1R3C [cytosol] (R-HSA-3777102)	0.743	5
UniProt:Q6PJW8 CNST			0.737	4
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.737	4
UniProt:Q8NI77 KIF18A	1	KIF18A [cytosol] (R-HSA-376239)	0.73	4
UniProt:Q86WC6 PPR27			0.715	5
UniProt:Q12972-1 PPP1R8			0.693	6
UniProt:Q96QC0 PP1RA			0.689	4
UniProt:Q9H6T3 RPAP3			0.676	4
UniProt:O94763 RMP			0.676	4
UniProt:Q14684 RRP1B			0.667	3
UniProt:Q6ZMQ8 LMTK1			0.667	3
UniProt:Q96T49 PP16B			0.666	4
UniProt:Q86XI6 PPR3B			0.666	4
UniProt:Q4KMQ1-2 TPRN			0.666	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:Q12972-2 PPP1R8			0.666	7
UniProt:O95685 PPR3D			0.659	3
UniProt:Q8TEC5 SH3R2			0.658	3
UniProt:Q7Z5V6 PPR32			0.658	3
UniProt:Q9H788 SH24A			0.656	3
UniProt:P46937 YAP1	7	p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345)	0.643	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.64	6
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.638	3
UniProt:Q9GZN8 CT027			0.638	3
UniProt:O35867 NEB1			0.618	3
UniProt:P49750 YLPM1			0.594	3
UniProt:Q4KMQ1 TPRN	1	TPRN [cytosol] (R-HSA-9663023)	0.594	3
UniProt:Q5T8A7 PPR26			0.592	2
UniProt:O00566 MPHOSPH10	1	MPHOSPH10 [nucleoplasm] (R-HSA-6790661)	0.592	2
UniProt:Q8NG31 KNL1	2	CASC5 [nucleoplasm] (R-HSA-606296) CASC5 [cytosol] (R-HSA-375322)	0.592	2
UniProt:O95400 CD2BP2	1	CD2BP2 [nucleoplasm] (R-HSA-72054)	0.592	2
UniProt:Q9HCH5 SYTL2			0.592	2
UniProt:K9N4V7 NCAP			0.59	2
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.59	2
UniProt:Q5JTV8 TOR1AIP1	1	TOR1AIP1 [cytosol] (R-HSA-9715083)	0.573	2
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.571	4
UniProt:Q8NHQ8 RASF8			0.569	3
UniProt:Q15834 CC85B			0.569	3
UniProt:Q9H792 PEAK1	1	PEAK1 [cytosol] (R-HSA-9715162)	0.569	3
UniProt:Q6UXN9 WDR82			0.569	3
UniProt:O94842 TOX4			0.569	3
UniProt:O14802 POLR3A	2	POLR3A [nucleoplasm] (R-HSA-83700) POLR3A [cytosol] (R-HSA-1964433)	0.569	3
UniProt:Q02833 RASF7			0.569	3
UniProt:A6NKD9 CC85C			0.569	3
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.569	3
UniProt:Q80W00 PP1RA			0.564	2
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:P43405-2 P434052			0.556	3
UniProt:Q6NXS1 IPP2B			0.556	3
UniProt:O14990 IPP2C			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:O95793 STAU1			0.553	2
UniProt:O95405 ZFYVE9			0.553	3
UniProt:Q96S59 RANBP9	1	RANBP9 [cytosol] (R-HSA-374586)	0.553	2
UniProt:Q96KR7 PHAR3			0.547	2
UniProt:Q9H7J1 PPR3E			0.547	2
UniProt:Q9UPR0 PLCL2			0.547	2
UniProt:Q7Z3T8 ZFYVE16	1	ZFYVE16 [early endosome membrane] (R-HSA-201645)	0.547	2
UniProt:Q8TEP8 CEP192	1	CEP192 [cytosol] (R-HSA-380319)	0.544	2
UniProt:Q14C87 T132D			0.544	2
UniProt:P49815 TSC2	4	p-S939,S1130,T1462-TSC2 [cytosol] (R-HSA-165164) p-S939,T1462-TSC2 [cytosol] (R-HSA-199484) TSC2 [cytosol] (R-HSA-2980548) p-S1387-TSC2 [cytosol] (R-HSA-3132769)	0.544	2
UniProt:Q9NX63 CHCHD3	3	CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583) CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910)	0.544	2
UniProt:Q9H4A3 WNK1	1	WNK1 [cytosol] (R-HSA-2672391)	0.544	2
UniProt:Q9HBF4 ZFYV1			0.544	2
UniProt:Q8TEL6 TRPC4AP	1	TRPC4AP [plasma membrane] (R-HSA-3211767)	0.544	2
UniProt:A8K8P3 SFI1	1	SFI1 [cytosol] (R-HSA-380265)	0.544	2
UniProt:P55199 ELL	1	ELL [nucleoplasm] (R-HSA-54257)	0.544	2
UniProt:Q92796 DLG3	2	DLG3 [plasma membrane] (R-HSA-443609) DLG3 [cytosol] (R-HSA-6794232)	0.544	2
UniProt:P16989 YBOX3			0.537	3
UniProt:P49790 NUP153	1	NUP153 [nucleoplasm] (R-HSA-157695)	0.527	2
UniProt:P09622 DLD	1	DLD [mitochondrial matrix] (R-HSA-69978)	0.527	2
UniProt:Q9ULJ8 NEB1			0.527	2
UniProt:O14727 APAF1	4	APAF1 [secretory granule lumen] (R-HSA-6801271) APAF1 [extracellular region] (R-HSA-6806465) APAF1 [ficolin-1-rich granule lumen] (R-HSA-6801301) APAF1 [cytosol] (R-HSA-50099)	0.524	2
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.524	2
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.524	2
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.524	3
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841)	0.524	4
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.524	2
UniProt:P05198 EIF2S1	2	EIF2S1 [cytosol] (R-HSA-72510) p-S52-EIF2S1 [cytosol] (R-HSA-381060)	0.509	2
UniProt:P61962 DCAF7	2	Unfolded DCAF7 [cytosol] (R-HSA-6813821) DCAF7 [nucleoplasm] (R-HSA-8863312)	0.508	2
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.508	2
UniProt:P36313 ICP34			0.508	4
UniProt:O08785 Clock	2	Clock [cytosol] (R-MMU-508720) p-S-Clock [nucleoplasm] (R-MMU-508670)	0.508	2
UniProt:O60828 PQBP1	1	PQBP1 [nucleoplasm] (R-HSA-8867889)	0.508	2
UniProt:Q76TK5 Q76TK5			0.499	2
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.499	2
UniProt:Q562F6 SGO2	1	SGOL2 [cytosol] (R-HSA-376242)	0.462	4

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