AMPK inhibits chREBP transcriptional activation activity

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Homo sapiens
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AMP-activated protein kinase (AMPK) is a sensor of cellular energy levels. A high cellular ratio of AMP:ATP triggers the phosphorylation and activation of AMPK. Activated AMPK in turn phosphorylates a wide array of target proteins, as shown in the figure below (reproduced from (Hardie et al. 2003), with the permission of D.G. Hardie). These targets include ChREBP (Carbohydrate Response Element Binding Protein), whose inactivation by phosphorylation reduces transcription of key enzymes of the glycolytic and lipogenic pathways.

Literature References
PubMed ID Title Journal Year
11724780 Mechanism for fatty acid sparing effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase

Kawaguchi, T, Osatomi, K, Yamashita, H, Kabashima, T, Uyeda, K

J Biol Chem 2002
12829246 Management of cellular energy by the AMP-activated protein kinase system

Hardie, DG, Scott, JW, Pan, DA, Hudson, ER

FEBS Lett 2003
15509864 The AMP-activated protein kinase pathway--new players upstream and downstream

Hardie, DG

J Cell Sci 2004
10698692 Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding

Cheung, PC, Salt, IP, Davies, SP, Hardie, DG, Carling, D

Biochem J 2000
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