Phosphorylation of ChREBP at Serine 556 by AMPK

Stable Identifier
R-HSA-163691
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of ChREBP at Serine 556 by AMPK
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In the nucleus, activated AMPK phosphorylates serine residue 556 of ChREBP (Carbohydrate Response Element Binding Protein). Phosphorylated ChREBP does not bind to ChRE chromosomal DNA sequence elements and thus loses its ability to promote transcription of genes involved in glycolysis and lipogenesis.
Participants
Input
Output
Participates
as an event of
Catalyst Activity

AMP-activated protein kinase activity of Activated AMPK heterotrimer [nucleoplasm]

Physical Entity
Activated AMPK heterotrimer [nucleoplasm] (Homo sapiens)
Activity
AMP-activated protein kinase activity (GO:0004679)
This event is regulated
Negatively by
Regulator
AMP [nucleoplasm]
Inferred From
Phosphorylation of rChREBP(Ser 568) by rAMPK (Rattus norvegicus)
Cross References
RHEA
Authored
Gopinathrao, G  (2005-05-13)
Reviewed
Hill, DP  (2024-02-13)
D'Eustachio, P  (2024-03-04)
Created
Gopinathrao, G  (2005-05-05)
Cite Us!