Reactome | NDUFS3 [mitochondrial matrix]

NDUFS3 [mitochondrial matrix]

Stable Identifier

R-HSA-163927

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

NADH-ubiquinone oxidoreductase 30 kDa subunit

Locations in the PathwayBrowser for interactor UniProt:Q9P0J0 NDUFA13

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External Reference Information

External Reference

UniProt:O75489 NDUFS3

Gene Names

NDUFS3

Chain

transit peptide:1-36, chain:37-264

Reference Genes

BioGPS Gene:4722 NDUFS3

COSMIC (genes):NDUFS3 NDUFS3

CTD Gene:4722 NDUFS3

dbSNP Gene:4722 NDUFS3

ENSEMBL:ENSG00000213619 NDUFS3

ENSEMBL_homo_sapiens_GENE:ENSG00000213619.11 NDUFS3

HGNC:7710 NDUFS3

KEGG Gene (Homo sapiens):4722 NDUFS3

Monarch:4722 NDUFS3

NCBI Gene:4722 NDUFS3

OMIM:603846 NDUFS3

UCSC:O75489 NDUFS3

Reference Transcript

RefSeq:NM_004551.2 NDUFS3

Other Identifiers

11757413_a_at

16724607

201740_PM_at

201740_at

3329905

3329906

3329908

3329911

3329914

3329917

3329919

3329921

3329922

35264_at

4722

7939825

A_14_P104947

GE54598

GO:0003824

GO:0003954

GO:0005215

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005747

GO:0005759

GO:0006091

GO:0006120

GO:0007005

GO:0008137

GO:0009055

GO:0009060

GO:0012501

GO:0016020

GO:0016491

GO:0016604

GO:0016651

GO:0021762

GO:0023052

GO:0030308

GO:0031966

GO:0032981

GO:0042776

GO:0043226

GO:0048856

GO:0055086

GO:0065003

GO:0070469

GO:0072593

GO:1901135

GO:2001243

HMNXSV003047296

ILMN_1756355

PH_hs_0019882

PH_hs_0035948

g4758787_3p_at

Participates

as a member of

Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)

as a component of

as an input of

NDUF subunits bind to form the IP subcomplex (Homo sapiens)

Other forms of this molecule

NDUFS3 [cytosol]

Inferred To

nuo-2 [mitochondrial matrix] (Caenorhabditis elegans)

ND-30 [mitochondrial matrix] (Drosophila melanogaster)

ndufs3 [mitochondrial matrix] (Danio rerio)

ndufs3 [mitochondrial matrix] (Xenopus tropicalis)

Ndufs3 [mitochondrial matrix] (Mus musculus)

Ndufs3 [mitochondrial matrix] (Rattus norvegicus)

nad9 [mitochondrial matrix] (Dictyostelium discoideum)

NDUFS3 [mitochondrial matrix] (Bos taurus)

NDUFS3 [mitochondrial matrix] (Canis familiaris)

NDUFS3 [mitochondrial matrix] (Gallus gallus)

NDUFS3 [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_004542.1

OpenTargets

ENSG00000213619

GeneCards

O75489

HPA

ENSG00000213619-NDUFS3

Ensembl

ENSG00000213619, ENSP00000263774, ENST00000263774

PRO

O75489

Pharos - Targets

O75489

Orphanet

16528

HMDB Protein

HMDBP00140

PDB

5XTD, 5XTI, 5XTH, 5XTB

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75306 NDUFS2	1	NDUFS2 [mitochondrial matrix] (R-HSA-6788520)	0.848	12
UniProt:Q16718 NDUFA5	2	NDUFA5 [endoplasmic reticulum membrane] (R-HSA-9714749) NDUFA5 [mitochondrial inner membrane] (R-HSA-60599)	0.845	13
UniProt:O43678 NDUFA2	1	NDUFA2 [mitochondrial inner membrane] (R-HSA-60178)	0.802	9
UniProt:Q9Y375 NDUFAF1	1	NDUFAF1 [mitochondrial inner membrane] (R-HSA-5689050)	0.788	6
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.788	10
UniProt:Q16795 NDUFA9	1	NDUFA9 [mitochondrial matrix] (R-HSA-163942)	0.788	10
UniProt:Q9BU61 NDUFAF3	1	NDUFAF3 [mitochondrial inner membrane] (R-HSA-5689126)	0.744	9
UniProt:O95182 NDUFA7	1	NDUFA7 [mitochondrial inner membrane] (R-HSA-59858)	0.725	7
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.725	9
UniProt:O00217 NDUFS8	1	NDUFS8 [mitochondrial matrix] (R-HSA-6788526)	0.725	7
UniProt:P28331 NDUFS1	1	NDUFS1 [mitochondrial matrix] (R-HSA-6788513)	0.725	7
UniProt:O95169 NDUFB8	4	NDUFB8 [mitochondrial inner membrane] (R-HSA-163938) NDUFB8(1-28) [mitochondrial matrix] (R-HSA-8986166) NDUFB8(1-186) [mitochondrial inner membrane] (R-HSA-8986184) NDUFB8(1-186) [mitochondrial intermembrane space] (R-HSA-8986140)	0.725	5
UniProt:Q9UI09 NDUFA12	1	NDUFA12 [mitochondrial inner membrane] (R-HSA-59864)	0.725	7
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.725	9
UniProt:O43181 NDUFS4	1	NDUFS4 [mitochondrial inner membrane] (R-HSA-163946)	0.725	7
UniProt:Q9Y6M9 NDUFB9	1	NDUFB9 [mitochondrial inner membrane] (R-HSA-60176)	0.643	6
UniProt:P03886 MT-ND1	1	MT-ND1 [mitochondrial inner membrane] (R-HSA-60551)	0.643	3
UniProt:Q9NX14 NDUFB11	1	NDUFB11 [mitochondrial inner membrane] (R-HSA-163933)	0.643	6
UniProt:Q9H845 ACAD9	1	ACAD9 [mitochondrial inner membrane] (R-HSA-5689049)	0.643	6
UniProt:O95167 NDUFA3	1	NDUFA3 [mitochondrial inner membrane] (R-HSA-60180)	0.643	5
UniProt:Q9P0J0 NDUFA13	8	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936) NDUFA13(41-49) [mitochondrial inner membrane] (R-HSA-9839958) NDUFA13(100-108) [mitochondrial inner membrane] (R-HSA-9839959) NDUFA13(109-144) [mitochondrial inner membrane] (R-HSA-9839968) NDUFA13(2-19) [mitochondrial inner membrane] (R-HSA-9839966) NDUFA13(69-99) [mitochondrial inner membrane] (R-HSA-9839964) NDUFA13(20-40) [mitochondrial inner membrane] (R-HSA-9839963) NDUFA13(50-68) [mitochondrial inner membrane] (R-HSA-9839961)	0.643	7
UniProt:O95168 NDUFB4	1	NDUFB4 [mitochondrial inner membrane] (R-HSA-59934)	0.643	6
UniProt:O43676 NDUFB3	1	NDUFB3 [mitochondrial inner membrane] (R-HSA-59930)	0.643	6
UniProt:O43674 NDUFB5	1	NDUFB5 [mitochondrial inner membrane] (R-HSA-163944)	0.643	5
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.643	3
UniProt:O43920 NDUFS5	1	NDUFS5 [mitochondrial inner membrane] (R-HSA-60226)	0.643	6
UniProt:P56181 NDUFV3	1	NDUFV3 [mitochondrial inner membrane] (R-HSA-163943)	0.643	6
UniProt:O95139 NDUFB6	1	NDUFB6 [mitochondrial inner membrane] (R-HSA-59938)	0.643	3
UniProt:P03915 MT-ND5	1	MT-ND5 [mitochondrial inner membrane] (R-HSA-60565)	0.643	3
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.643	7
UniProt:Q9P032 NDUFAF4	1	NDUFAF4 [mitochondrial inner membrane] (R-HSA-5689124)	0.643	10
UniProt:P51970 NDUFA8	1	NDUFA8 [mitochondrial inner membrane] (R-HSA-60627)	0.564	5
UniProt:Q5JUW0-3 KRBOX4			0.556	3
UniProt:Q9H8H3 TMT1A	2	METTL7A [extracellular region] (R-HSA-6800468) METTL7A [tertiary granule lumen] (R-HSA-6800170)	0.556	3
UniProt:Q66PJ3-4 ARL6IP4			0.556	3
IntAct:EBI-25876377 CCSB			0.556	3
UniProt:P17152 TMEM11	1	TMEM11 [mitochondrial inner membrane] (R-HSA-8949578)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	2
UniProt:P03923 MT-ND6	1	MT-ND6 [mitochondrial inner membrane] (R-HSA-60569)	0.527	2
UniProt:P17568 NDUFB7	1	NDUFB7 [mitochondrial inner membrane] (R-HSA-59940)	0.527	5
UniProt:Q86Y39 NDUFA11	1	NDUFA11 [mitochondrial inner membrane] (R-HSA-163923)	0.527	4
UniProt:O75438 NDUFB1	1	NDUFB1 [mitochondrial inner membrane] (R-HSA-60214)	0.527	5
UniProt:P56556 NDUFA6	1	NDUFA6 [mitochondrial inner membrane] (R-HSA-59932)	0.527	5
UniProt:O96000 NDUFB10	1	NDUFB10 [mitochondrial inner membrane] (R-HSA-60194)	0.527	4
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.527	4
UniProt:Q5TEU4 NDUFAF5	1	NDUFAF5 [mitochondrial inner membrane] (R-HSA-5689127)	0.527	2
UniProt:P03905 MT-ND4	1	MT-ND4 [mitochondrial inner membrane] (R-HSA-60561)	0.527	2
UniProt:Q9H9B4 SFXN1			0.483	2
UniProt:O75880 SCO1	1	SCO1 [mitochondrial inner membrane] (R-HSA-5336170)	0.483	3
UniProt:P13073 COX4I1	2	COX4I1 [mitochondrial inner membrane] (R-HSA-164305) COX4I1 [mitochondrial intermembrane space] (R-HSA-9865413)	0.483	2
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171)	0.483	5

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