Reactome | NDUFV2 [mitochondrial inner membrane]

NDUFV2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-163939

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase 24 kDa subunit

Locations in the PathwayBrowser for interactor IntAct:EBI-25850457 CCSB

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External Reference Information

External Reference

UniProt:P19404 NDUFV2

Gene Names

NDUFV2

Chain

transit peptide:1-32, chain:33-249

Reference Genes

BioGPS Gene:4729 NDUFV2

COSMIC (genes):NDUFV2 NDUFV2

CTD Gene:4729 NDUFV2

dbSNP Gene:4729 NDUFV2

ENSEMBL:ENSG00000178127 NDUFV2

HGNC:7717 NDUFV2

KEGG:hsa:4729 NDUFV2

Monarch:4729 NDUFV2

NCBI Gene:4729 NDUFV2

OMIM:600532 NDUFV2

UCSC:P19404 NDUFV2

Reference Transcript

RefSeq:NM_021074.5 NDUFV2

Other Identifiers

11718282_s_at

16850849

202941_PM_at

202941_at

31359_at

34893_at

3778208

3778209

3778210

3778211

3778212

3778213

3778214

3778215

3778216

3778217

3778218

3778224

3778225

3778226

3778227

3778228

3778229

3778231

3778234

3778236

3778237

3778246

3778247

3870190

3870192

4729

8020058

8039068

A_23_P130418

GE82585

GE85324

GO:0003824

GO:0003954

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0006091

GO:0006120

GO:0007399

GO:0008137

GO:0009055

GO:0009060

GO:0016491

GO:0042776

GO:0043226

GO:0045271

GO:0046872

GO:0048738

GO:0048856

GO:0051537

GO:0055085

GO:0055086

GO:1901135

GO:1902600

HMNXSV003048082

ILMN_2086417

M22538_at

PH_hs_0028904

TC18000041.hg

g10835024_3p_at

Participates

as an input of

NUBPL transfers 4Fe-4S to NDUFV1, V2 (Homo sapiens)

as a component of

NDUFV2:4Fe-4S [mitochondrial inner membrane] (Homo sapiens)

Inferred To

ND-24 [mitochondrial inner membrane] (Drosophila melanogaster)

Ndufv2 [mitochondrial inner membrane] (Mus musculus)

Ndufv2 [mitochondrial inner membrane] (Rattus norvegicus)

NDUFV2 [mitochondrial inner membrane] (Bos taurus)

NDUFV2 [mitochondrial inner membrane] (Caenorhabditis elegans)

NDUFV2 [mitochondrial inner membrane] (Canis familiaris)

NDUFV2 [mitochondrial inner membrane] (Gallus gallus)

NDUFV2 [mitochondrial inner membrane] (Sus scrofa)

ndufv2 [mitochondrial inner membrane] (Danio rerio)

ndufv2 [mitochondrial inner membrane] (Dictyostelium discoideum)

ndufv2 [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_066552.2

OpenTargets

ENSG00000178127

ENSEMBL

ENSG00000178127, ENSP00000327268, ENST00000318388

GeneCards

NDUFV2

HPA

ENSG00000178127-NDUFV2

PRO

P19404

Pharos - Targets

P19404

GlyGen

P19404

Orphanet

NDUFV2

HMDB Protein

HMDBP00142

PDB

5XTB, 5XTI, 5XTH, 5XTD

Interactors (120)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.788	10
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.782	7
UniProt:Q16795 NDUFA9	1	NDUFA9 [mitochondrial matrix] (R-HSA-163942)	0.744	6
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.725	6
UniProt:O75306 NDUFS2	1	NDUFS2 [mitochondrial matrix] (R-HSA-6788520)	0.725	4
UniProt:O43678 NDUFA2	1	NDUFA2 [mitochondrial inner membrane] (R-HSA-60178)	0.669	4
UniProt:O43181 NDUFS4	1	NDUFS4 [mitochondrial inner membrane] (R-HSA-163946)	0.643	3
UniProt:P03915 MT-ND5	1	MT-ND5 [mitochondrial inner membrane] (R-HSA-60565)	0.643	3
UniProt:O43920 NDUFS5	1	NDUFS5 [mitochondrial inner membrane] (R-HSA-60226)	0.643	4
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.643	4
UniProt:Q9UI09 NDUFA12	1	NDUFA12 [mitochondrial inner membrane] (R-HSA-59864)	0.643	4
UniProt:P56556 NDUFA6	1	NDUFA6 [mitochondrial inner membrane] (R-HSA-59932)	0.643	3
UniProt:P28331 NDUFS1	1	NDUFS1 [mitochondrial matrix] (R-HSA-6788513)	0.643	3
UniProt:P51970 NDUFA8	1	NDUFA8 [mitochondrial inner membrane] (R-HSA-60627)	0.643	3
UniProt:P56181 NDUFV3	1	NDUFV3 [mitochondrial inner membrane] (R-HSA-163943)	0.643	5
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.558	6
UniProt:Q8IUI8 CRLF3			0.556	3
UniProt:Q96HD1-2 Q96HD12			0.556	3
UniProt:Q8N7B6-2 PACRGL			0.556	3
IntAct:EBI-25850457 CCSB			0.556	3
UniProt:Q9Y261-2 Q9Y2612			0.556	3
UniProt:Q86V28 Q86V28			0.556	3
UniProt:Q96QF0-7 RAB3IP			0.556	3
UniProt:Q8WXF7 ATLA1			0.556	3
UniProt:Q86WT6-2 TRIM69			0.556	3
UniProt:Q9NRY5 FAM114A2	2	FAM114A2(1-327)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802525) FAM114A2(1-327)-BRAF(439-766) fusion [cytosol] (R-HSA-6802321)	0.556	3
UniProt:Q71DI3 H3C15	20	2xAcK-HIST2H3A [nucleoplasm] (R-HSA-427525) Me2aR27-HIST2H3A [nucleoplasm] (R-HSA-5229057) Me2aR18-HIST2H3A [nucleoplasm] (R-HSA-5229063) Me2sR9-HIST2H3A [nucleoplasm] (R-HSA-5211327) Me2sR3-HIST2H3A [nucleoplasm] (R-HSA-5218930) AcK9,14-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8870892) AcK14,18,79-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871273) AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871304) AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871292) AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8865607) AcK14,18-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871296) AcK14,18,79-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871290) AcK14,18-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871302) AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871289) Me2K28-HIST2H3A [nucleoplasm] (R-HSA-4754197) MeK37-HIST2H3A [nucleoplasm] (R-HSA-4722131) MeK80-HIST2H3A [nucleoplasm] (R-HSA-5649805) Me3K80-HIST2H3A [nucleoplasm] (R-HSA-5649798) Me2K80-HIST2H3A [nucleoplasm] (R-HSA-5649803) Me3K37-HIST2H3A [nucleoplasm] (R-HSA-5638140)	0.556	3
UniProt:Q8N6F8 MET27			0.556	3
UniProt:Q9Y3D2 MSRB2	1	MSRB2 [cytosol] (R-HSA-5676906)	0.556	3
UniProt:Q96D59 RN183			0.556	3
UniProt:P43356 MAGA2			0.556	3
UniProt:Q8WWW0-2 RASSF5			0.556	3
UniProt:Q5T2W1 NHRF3			0.556	3
UniProt:P57052 RBM11			0.556	3
UniProt:P58304 VSX2			0.556	3
UniProt:O75436 VPS26A	1	VPS26A [cytosol] (R-HSA-3247739)	0.556	3
UniProt:Q9NS23-4 RASSF1			0.556	6
UniProt:P63010-2 AP2B1			0.556	3
UniProt:Q86VK4-3 ZNF410			0.556	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.556	3
UniProt:Q8N6K7-2 SAMD3			0.556	3
UniProt:Q6AZY7-2 Q6AZY72			0.556	3
UniProt:Q9ULX5 RN112			0.556	3
UniProt:Q6X4W1-6 NSMF			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q86UV6-2 TRIM74			0.556	3
UniProt:Q8WUW1 BRK1	1	BRK1 [cytosol] (R-HSA-1671645)	0.556	3
UniProt:P57729 RAB38	3	GGC-RAB38 [melanosome membrane] (R-HSA-8877740) GGC-RAB38 [cytosol] (R-HSA-8873999) RAB38 [cytosol] (R-HSA-8873711)	0.556	3
UniProt:P06241-3 FYN			0.556	3
UniProt:Q9UNS2 COPS3	2	COPS3 [nucleoplasm] (R-HSA-5697017) COPS3 [cytosol] (R-HSA-416973)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [cytosol] (R-HSA-5654211) SPRED2 [plasma membrane] (R-HSA-5658229)	0.556	3
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.556	3
IntAct:EBI-25850770 CCSB			0.556	3
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.556	3
UniProt:O15381-5 O153815			0.556	3
UniProt:P17023 ZNF19	1	ZNF19 [nucleoplasm] (R-HSA-974992)	0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:Q7L7L0 H2AC25	11	AcK-HIST3H2A [nucleoplasm] (R-HSA-4551313) HIST3H2A [nucleoplasm] (R-HSA-4549209) MeR12-HIST3H2A [nucleoplasm] (R-HSA-5229220) Me2aR12-HIST3H2A [nucleoplasm] (R-HSA-5229302) MeR4-HIST3H2A [nucleoplasm] (R-HSA-5244613) Me2aR4-HIST3H2A [nucleoplasm] (R-HSA-5244626) MeR30-HIST3H2A [nucleoplasm] (R-HSA-5244566) Me2aR30-HIST3H2A [nucleoplasm] (R-HSA-5244532) AcK6-HIST3H2A [nucleoplasm] (R-HSA-4568608) Ub-HIST3H2A [nucleoplasm] (R-HSA-6782531) K63polyUb-HIST3H2A [nucleoplasm] (R-HSA-6783249)	0.556	3
UniProt:Q9GZS3 SKIC8	2	WDR61 [cytosol] (R-HSA-8931534) WDR61 [nucleoplasm] (R-HSA-8866696)	0.556	3
UniProt:Q9NVV9 THAP1			0.556	3
UniProt:Q96I34 PP16A			0.556	3
UniProt:Q96FT7-4 ASIC4			0.556	3
UniProt:Q8IUW3 SPA2L			0.556	3
UniProt:Q92613 JADE3	1	PHF16 [nucleoplasm] (R-HSA-3321851)	0.556	3
UniProt:Q9UNY5 ZN232			0.556	3
UniProt:Q8N0Y2-2 ZNF444			0.556	3
UniProt:Q8NHS9 SPT22			0.556	3
UniProt:Q99457 NP1L3			0.556	3
UniProt:Q96PV6 LENG8			0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:Q9BZZ5-2 API5			0.556	3
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.556	3
UniProt:P20042 EIF2S2	1	EIF2S2 [cytosol] (R-HSA-72512)	0.556	3
UniProt:Q5VYS8-5 TUT7			0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926)	0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.556	3
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.556	3
UniProt:Q16625 OCLN	4	OCLN [plasma membrane] (R-HSA-351846) OCLN(321-522) [plasma membrane] (R-HSA-351873) OCLN(1-320) [plasma membrane] (R-HSA-351854) OCLN [cell junction] (R-HSA-2160944)	0.556	3
UniProt:P07437 TUBB	3	TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816)	0.556	3
UniProt:O95391 SLU7	1	hSLU7 [nucleoplasm] (R-HSA-72073)	0.556	3
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.556	3
UniProt:Q96EY1-3 DNAJA3			0.556	3
UniProt:Q6DKI2 LEG9C			0.556	3
UniProt:Q6P1J6-2 PLB1			0.556	3
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.556	3
UniProt:Q9BR01-2 Q9BR012			0.556	3
UniProt:P32242 OTX1			0.556	3
UniProt:P10073 ZSC22			0.556	3
IntAct:EBI-25831465 CCSB			0.556	3
UniProt:P62158 CALM			0.556	3
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.556	3
UniProt:Q16549 PCSK7	1	PCSK7 [Golgi membrane] (R-HSA-9933731)	0.556	3
UniProt:Q6ZMI0-5 PPP1R21			0.556	3
UniProt:Q9Y575-3 ASB3			0.556	3
UniProt:O95182 NDUFA7	1	NDUFA7 [mitochondrial inner membrane] (R-HSA-59858)	0.527	3
UniProt:Q96LL9 DJC30			0.527	3
UniProt:O00217 NDUFS8	1	NDUFS8 [mitochondrial matrix] (R-HSA-6788526)	0.527	2
UniProt:P17568 NDUFB7	1	NDUFB7 [mitochondrial inner membrane] (R-HSA-59940)	0.527	2
UniProt:O95299 NDUFA10	1	NDUFA10 [mitochondrial inner membrane] (R-HSA-163937)	0.527	2
UniProt:O95298 NDUFC2	3	NDUFC2 [mitochondrial inner membrane] (R-HSA-59860) NDUFC2 [azurophil granule membrane] (R-HSA-6799211) NDUFC2 [plasma membrane] (R-HSA-6806276)	0.527	2
UniProt:O75438 NDUFB1	1	NDUFB1 [mitochondrial inner membrane] (R-HSA-60214)	0.527	2
UniProt:O95168 NDUFB4	1	NDUFB4 [mitochondrial inner membrane] (R-HSA-59934)	0.527	2
UniProt:O95169 NDUFB8	4	NDUFB8 [mitochondrial inner membrane] (R-HSA-163938) NDUFB8(1-186) [mitochondrial inner membrane] (R-HSA-8986184) NDUFB8(1-28) [mitochondrial matrix] (R-HSA-8986166) NDUFB8(1-186) [mitochondrial intermembrane space] (R-HSA-8986140)	0.527	2
UniProt:O96000 NDUFB10	1	NDUFB10 [mitochondrial inner membrane] (R-HSA-60194)	0.527	2
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	3
UniProt:Q9Y6M9 NDUFB9	1	NDUFB9 [mitochondrial inner membrane] (R-HSA-60176)	0.527	2
UniProt:Q9NX14 NDUFB11	1	NDUFB11 [mitochondrial inner membrane] (R-HSA-163933)	0.527	3
UniProt:O43676 NDUFB3	1	NDUFB3 [mitochondrial inner membrane] (R-HSA-59930)	0.527	3
UniProt:O43674 NDUFB5	1	NDUFB5 [mitochondrial inner membrane] (R-HSA-163944)	0.527	2
UniProt:Q8N0U4 F185A			0.527	2
UniProt:Q9P0J0 NDUFA13	8	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936) NDUFA13(41-49) [mitochondrial inner membrane] (R-HSA-9839958) NDUFA13(100-108) [mitochondrial inner membrane] (R-HSA-9839959) NDUFA13(109-144) [mitochondrial inner membrane] (R-HSA-9839968) NDUFA13(2-19) [mitochondrial inner membrane] (R-HSA-9839966) NDUFA13(69-99) [mitochondrial inner membrane] (R-HSA-9839964) NDUFA13(20-40) [mitochondrial inner membrane] (R-HSA-9839963) NDUFA13(50-68) [mitochondrial inner membrane] (R-HSA-9839961)	0.527	2
UniProt:O95139 NDUFB6	1	NDUFB6 [mitochondrial inner membrane] (R-HSA-59938)	0.527	2
UniProt:P03905 MT-ND4	1	MT-ND4 [mitochondrial inner membrane] (R-HSA-60561)	0.527	2
UniProt:P03886 MT-ND1	1	MT-ND1 [mitochondrial inner membrane] (R-HSA-60551)	0.527	2

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