Reactome | NDUFS4 [mitochondrial inner membrane]

NDUFS4 [mitochondrial inner membrane]

Stable Identifier

R-HSA-163946

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase 18 kDa subunit

Locations in the PathwayBrowser for interactor UniProt:P27930 IL1R2

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External Reference Information

External Reference

UniProt:O43181 NDUFS4

Gene Names

NDUFS4

Chain

transit peptide:1-42, chain:43-175

Reference Genes

BioGPS Gene:4724 NDUFS4

COSMIC (genes):NDUFS4 NDUFS4

CTD Gene:4724 NDUFS4

dbSNP Gene:4724 NDUFS4

ENSEMBL:ENSG00000164258 NDUFS4

ENSEMBL_homo_sapiens_GENE:ENSG00000164258.12 NDUFS4

HGNC:7711 NDUFS4

KEGG Gene (Homo sapiens):4724 NDUFS4

Monarch:4724 NDUFS4

NCBI Gene:4724 NDUFS4

OMIM:602694 NDUFS4

UCSC:O43181 NDUFS4

Reference Transcript

RefSeq:NM_002495.3 NDUFS4

Other Identifiers

11716340_a_at

16984741

209303_PM_at

209303_at

2809425

2809432

2809437

2809442

2809451

2809452

2809453

2809454

38695_at

45509_g_at

4724

8105311

GE61878

GO:0001932

GO:0003824

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0007005

GO:0007420

GO:0008137

GO:0009060

GO:0016020

GO:0016491

GO:0022900

GO:0032981

GO:0036211

GO:0042776

GO:0043226

GO:0045333

GO:0048146

GO:0048856

GO:0051591

GO:0055086

GO:0065003

GO:0070469

GO:0072593

GO:1901135

HMNXSV003026523

PH_hs_0001068

g13528959_3p_at

Participates

as a component of

as an input of

NDUF subunits bind to form the FP subcomplex (Homo sapiens)

Inferred To

ndufs4 [mitochondrial inner membrane] (Danio rerio)

ndufs4 [mitochondrial inner membrane] (Xenopus tropicalis)

ND-18 [mitochondrial inner membrane] (Drosophila melanogaster)

lpd-5 [mitochondrial inner membrane] (Caenorhabditis elegans)

Ndufs4 [mitochondrial inner membrane] (Mus musculus)

Ndufs4 [mitochondrial inner membrane] (Rattus norvegicus)

NDUFS4 [mitochondrial inner membrane] (Bos taurus)

NDUFS4 [mitochondrial inner membrane] (Canis familiaris)

NDUFS4 [mitochondrial inner membrane] (Gallus gallus)

NDUFS4 [mitochondrial inner membrane] (Sus scrofa)

Cross References

RefSeq

NP_002486.1

OpenTargets

ENSG00000164258

HPA

ENSG00000164258-NDUFS4

GeneCards

O43181

Ensembl

ENSP00000296684, ENSG00000164258, ENST00000296684

PRO

O43181

Pharos - Targets

O43181

Orphanet

16529

HMDB Protein

HMDBP00137

PDB

5XTD, 5XTI, 5XTB, 5XTH

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.725	7
UniProt:Q9P0J0 NDUFA13	8	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936) NDUFA13(41-49) [mitochondrial inner membrane] (R-HSA-9839958) NDUFA13(100-108) [mitochondrial inner membrane] (R-HSA-9839959) NDUFA13(109-144) [mitochondrial inner membrane] (R-HSA-9839968) NDUFA13(2-19) [mitochondrial inner membrane] (R-HSA-9839966) NDUFA13(69-99) [mitochondrial inner membrane] (R-HSA-9839964) NDUFA13(20-40) [mitochondrial inner membrane] (R-HSA-9839963) NDUFA13(50-68) [mitochondrial inner membrane] (R-HSA-9839961)	0.643	4
UniProt:O43678 NDUFA2	1	NDUFA2 [mitochondrial inner membrane] (R-HSA-60178)	0.564	3
UniProt:O95182 NDUFA7	1	NDUFA7 [mitochondrial inner membrane] (R-HSA-59858)	0.527	3
UniProt:P27930 IL1R2	1	IL1R2 [plasma membrane] (R-HSA-197598)	0.527	3
UniProt:Q8WTR4 GDPD5	1	GDPD5 [endoplasmic reticulum membrane] (R-HSA-6814136)	0.527	2
UniProt:Q9UI09 NDUFA12	1	NDUFA12 [mitochondrial inner membrane] (R-HSA-59864)	0.527	3
UniProt:O43920 NDUFS5	1	NDUFS5 [mitochondrial inner membrane] (R-HSA-60226)	0.527	3
UniProt:Q16795 NDUFA9	1	NDUFA9 [mitochondrial matrix] (R-HSA-163942)	0.527	4
UniProt:P51970 NDUFA8	1	NDUFA8 [mitochondrial inner membrane] (R-HSA-60627)	0.527	2
UniProt:Q9GZM5 YIPF3			0.527	2
UniProt:Q8NCL4 GALNT6	1	GALNT6 [Golgi membrane] (R-HSA-913608)	0.527	2
UniProt:O95169 NDUFB8	4	NDUFB8 [mitochondrial inner membrane] (R-HSA-163938) NDUFB8(1-28) [mitochondrial matrix] (R-HSA-8986166) NDUFB8(1-186) [mitochondrial inner membrane] (R-HSA-8986184) NDUFB8(1-186) [mitochondrial intermembrane space] (R-HSA-8986140)	0.527	2
UniProt:P19526 FUT1	1	FUT1 [Golgi membrane] (R-HSA-9034059)	0.527	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.527	2
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.527	4
UniProt:P56181 NDUFV3	1	NDUFV3 [mitochondrial inner membrane] (R-HSA-163943)	0.527	4
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	3
UniProt:O95292 VAPB	2	VAPB [endoplasmic reticulum membrane] (R-HSA-429718) VAPB [Golgi membrane] (R-HSA-9715115)	0.527	2

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