Reactome | PRKAG2 [nucleoplasm]

PRKAG2 [nucleoplasm]

Stable Identifier

R-HSA-164130

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

AMPK gamma2

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        AMPK phosphorylates TP53 (Homo sapiens)
        
        Activated AMPK heterotrimer [nucleoplasm] (Homo sapiens)
        
        AMPK gamma [nucleoplasm] (Homo sapiens)
        
        PRKAG2 [nucleoplasm] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Activation of PPARGC1A (PGC-1alpha) by phosphorylation (Homo sapiens)
    - AMPK phosphorylates PPARGC1A (Homo sapiens)
      - p-AMPK heterotrimer:AMP [nucleoplasm] (Homo sapiens)
        
        p-AMPK heterotrimer [nucleoplasm] (Homo sapiens)
        
        AMPK gamma [nucleoplasm] (Homo sapiens)
        
        PRKAG2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UGJ0 PRKAG2

Gene Names

PRKAG2

Chain

chain:1-569

Reference Genes

BioGPS Gene:51422 PRKAG2

COSMIC (genes):PRKAG2 PRKAG2

CTD Gene:51422 PRKAG2

dbSNP Gene:51422 PRKAG2

ENSEMBL:ENSG00000106617 PRKAG2

ENSEMBL_homo_sapiens_GENE:ENSG00000106617.16 PRKAG2

HGNC:9386 PRKAG2

KEGG Gene (Homo sapiens):51422 PRKAG2

Monarch:51422 PRKAG2

NCBI Gene:51422 PRKAG2

OMIM:602743 PRKAG2

UCSC:Q9UGJ0 PRKAG2

Reference Transcript

Other Identifiers

11718377_a_at

11718378_s_at

11718379_x_at

11736245_a_at

17064562

218292_PM_s_at

218292_s_at

222582_PM_at

222582_at

233748_PM_x_at

233748_x_at

3079805

3079806

3079807

3079808

3079809

3079816

3079817

3079819

3079822

3079823

3079824

3079825

3079828

3079831

3079832

3079836

3079837

3079854

3079855

3079856

3079857

3079858

3079872

3079925

3079926

3079927

3079930

3079937

3079969

3079970

46697_at

51422

8143961

A_23_P314760

A_23_P44366

GE61181

GE82091

GO:0000166

GO:0003824

GO:0004679

GO:0004862

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005975

GO:0005977

GO:0006091

GO:0006110

GO:0006469

GO:0006629

GO:0006631

GO:0006633

GO:0006754

GO:0008603

GO:0008607

GO:0010800

GO:0016126

GO:0016208

GO:0016301

GO:0016310

GO:0016740

GO:0019217

GO:0019887

GO:0019901

GO:0023052

GO:0030295

GO:0031588

GO:0031669

GO:0035556

GO:0036211

GO:0043226

GO:0043531

GO:0045860

GO:0046320

GO:0046324

GO:0055085

GO:0055086

GO:0098772

GO:0140096

GO:1901135

HMNXSV003050478

Hs.259842.2.A1_3p_a_at

ILMN_1749419

ILMN_1797531

ILMN_2293872

ILMN_2387919

PH_hs_0013613

g12642941_3p_at

Participates

as a component of

as a member of

AMPK gamma [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PRKAG2 [cytosol]

Inferred To

prkag [nucleoplasm] (Dictyostelium discoideum)

aakg-2 [nucleoplasm] (Caenorhabditis elegans)

SNF4Agamma [nucleoplasm] (Drosophila melanogaster)

aakg-3 [nucleoplasm] (Caenorhabditis elegans)

aakg-4 [nucleoplasm] (Caenorhabditis elegans)

Homologues of PRKAG2 [nucleoplasm] (Caenorhabditis elegans)

aakg-5 [nucleoplasm] (Caenorhabditis elegans)

PRKAG2 [nucleoplasm] (Bos taurus)

PRKAG2 [nucleoplasm] (Canis familiaris)

PRKAG2 [nucleoplasm] (Gallus gallus)

PRKAG2 [nucleoplasm] (Mus musculus)

PRKAG2 [nucleoplasm] (Saccharomyces cerevisiae)

PRKAG2 [nucleoplasm] (Schizosaccharomyces pombe)

PRKAG2 [nucleoplasm] (Sus scrofa)

Prkag2 [nucleoplasm] (Rattus norvegicus)

aakg-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001291460.1, NP_057287.2, NP_001035723.1, NP_001291456.1, NP_077747.1, XP_016867759.1

Guide to Pharmacology - Targets

1546

OpenTargets

ENSG00000106617

HPA

ENSG00000106617-PRKAG2

GeneCards

Q9UGJ0

Ensembl

ENST00000476632, ENST00000418337, ENSP00000287878, ENSG00000106617, ENSP00000376549, ENSP00000499025, ENSP00000498796, ENST00000392801, ENSP00000387386, ENSP00000499103, ENSP00000419493, ENST00000652159, ENST00000651764, ENST00000287878, ENST00000651378

PRO

Q9UGJ0

Pharos - Targets

Q9UGJ0

Orphanet

15138

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.527	4