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UQCRC1 [mitochondrial inner membrane]
Stable Identifier
R-HSA-164284
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Ubiquinol-cytochrome-c reductase complex core protein I, Complex III core protein I
Locations in the PathwayBrowser for interactor UniProt:P26641 EEF1G
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex III assembly (Homo sapiens)
Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH (Homo sapiens)
UQCRC1 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31930 UQCRC1
Gene Names
UQCRC1
Chain
transit peptide:1-34, chain:35-480
Reference Genes
BioGPS Gene:7384 UQCRC1
COSMIC (genes):UQCRC1 UQCRC1
CTD Gene:7384 UQCRC1
dbSNP Gene:7384 UQCRC1
ENSEMBL:ENSG00000010256 UQCRC1
ENSEMBL_homo_sapiens_GENE:ENSG00000010256.11 UQCRC1
HGNC:12585 UQCRC1
KEGG Gene (Homo sapiens):7384 UQCRC1
Monarch:7384 UQCRC1
NCBI Gene:7384 UQCRC1
OMIM:191328 UQCRC1
UCSC:P31930 UQCRC1
Reference Transcript
RefSeq:NM_003365.2 UQCRC1
Other Identifiers
11743979_a_at
11747855_a_at
16953568
201903_PM_at
201903_at
2673510
2673511
2673512
2673516
2673517
2673518
2673519
2673521
2673522
2673524
2673526
2673527
2673529
2673530
2673533
2673534
283_at
7384
8087100
GE57651
GO:0003824
GO:0005215
GO:0005515
GO:0005739
GO:0005743
GO:0005746
GO:0005750
GO:0006091
GO:0006119
GO:0006122
GO:0008121
GO:0009060
GO:0014823
GO:0016020
GO:0016491
GO:0031625
GO:0043226
GO:0043279
GO:0044877
GO:0045333
GO:0046872
GO:0055085
GO:0070469
GO:1902600
L16842_at
TC03001384.hg
g4507840_3p_at
Participates
as an input of
Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH (Homo sapiens)
as a component of
Late core complex monomer [mitochondrial inner membrane] (Homo sapiens)
Late core complex:UQCR10:UQCR11:holo-UQCRFS1(1-274) [mitochondrial inner membrane] (Homo sapiens)
Late core complex:UQCR10:UQCR11:holo-UQCRFS1(79-274):Fragments [mitochondrial inner membrane] (Homo sapiens)
Complex III monomer [mitochondrial inner membrane] (Homo sapiens)
Inferred To
UQCR-C1 [mitochondrial inner membrane]
(Drosophila melanogaster)
UQCRC1 [mitochondrial inner membrane]
(Bos taurus)
UQCRC1 [mitochondrial inner membrane]
(Caenorhabditis elegans)
UQCRC1 [mitochondrial inner membrane]
(Dictyostelium discoideum)
UQCRC1 [mitochondrial inner membrane]
(Gallus gallus)
UQCRC1 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
UQCRC1 [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
UQCRC1 [mitochondrial inner membrane]
(Sus scrofa)
ucr-1 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Uqcrc1 [mitochondrial inner membrane]
(Mus musculus)
Uqcrc1 [mitochondrial inner membrane]
(Rattus norvegicus)
uqcrc1 [mitochondrial inner membrane]
(Danio rerio)
COR1 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
Homologues of UQCRC1 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Homologues of UQCRC1 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_003356.2
OpenTargets
ENSG00000010256
HPA
ENSG00000010256-UQCRC1
GeneCards
P31930
Ensembl
ENSG00000010256
,
ENST00000203407
,
ENSP00000203407
PRO
P31930
Pharos - Targets
P31930
HMDB Protein
HMDBP00987
PDB
5XTH
,
5XTE
,
5XTI
Interactors (41)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22695 UQCRC2
1
UQCRC2 [mitochondrial inner membrane]
(R-HSA-164280)
0.688
4
UniProt:O14949 UQCRQ
1
UQCRQ [mitochondrial inner membrane]
(R-HSA-164283)
0.669
4
UniProt:P14927 UQCRB
1
UQCRB [mitochondrial inner membrane]
(R-HSA-164287)
0.669
5
UniProt:Q9UDW1 UQCR10
1
UQCR10 [mitochondrial inner membrane]
(R-HSA-164282)
0.564
3
UniProt:Q96JM7-2 L3MBTL3
0.556
3
UniProt:Q96MN9-2 Q96MN92
0.556
3
UniProt:Q8N5Z5 KCD17
0.556
3
UniProt:C9J082 C9J082
0.556
3
UniProt:Q8N8E2 ZN513
0.556
3
UniProt:Q9Y6G5 COMMD10
2
COMMD10 [nucleoplasm]
(R-HSA-8955101)
COMMD10 [cytosol]
(R-HSA-8955105)
0.556
3
UniProt:Q8WTV1 THAP3
0.556
3
UniProt:Q8N108-16 MIER1
0.556
3
UniProt:Q9HC44 GPBL1
0.556
3
UniProt:Q9P0T4 ZN581
0.556
3
UniProt:O95947 TBX6
1
TBX6 [nucleoplasm]
(R-HSA-9793377)
0.556
3
UniProt:P26641 EEF1G
3
EEF1G [cytosol]
(R-HSA-156925)
EEF1G(1-343)-ALK(1106-1620) fusion [cytosol]
(R-HSA-9710839)
EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol]
(R-HSA-9710850)
0.556
3
UniProt:Q9UHV9 PFDN2
1
PFDN2 [cytosol]
(R-HSA-379544)
0.556
3
UniProt:CCDC26 A0A024R9H7
0.556
3
UniProt:Q8IV13 CCNJL
0.556
3
UniProt:Q9BUA3 SPNDC
0.556
3
UniProt:Q14457 BECN1
4
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
BECN1 [cytosol]
(R-HSA-1632841)
0.556
3
UniProt:Q00169 PITPNA
1
PITPNA [cytosol]
(R-HSA-418391)
0.556
3
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
PRMT5 [cytosol]
(R-HSA-191876)
0.556
3
UniProt:Q9UNY5 ZN232
0.556
3
UniProt:Q9BZM4 ULBP3
1
ULBP3 [plasma membrane]
(R-HSA-198076)
0.556
3
UniProt:P52566 ARHGDIB
1
ARHGDIB [cytosol]
(R-HSA-195081)
0.556
3
UniProt:O95416 SOX14
0.556
3
UniProt:Q9UFG5 CS025
0.556
3
UniProt:Q9BRT8 ZNG1A
0.556
3
IntAct:EBI-25895235 CCSB
0.556
3
UniProt:O43704 SULT1B1
1
SULT1B1 [cytosol]
(R-HSA-176551)
0.556
3
UniProt:Q6ZMY6-2 Q6ZMY62
0.556
3
UniProt:Q06547-2 GABPB1
1
NRF2 beta-2 subunit [nucleoplasm]
(R-HSA-1592200)
0.556
3
UniProt:Q8WU43 CB015
0.556
3
IntAct:EBI-25895034 CCSB
0.556
3
UniProt:Q9UI10 EIF2B4
1
EIF2B4 [cytosol]
(R-HSA-72521)
0.556
3
UniProt:P07919 UQCRH
1
UQCRH [mitochondrial inner membrane]
(R-HSA-164286)
0.527
2
UniProt:P35610 SOAT1
1
SOAT1 [endoplasmic reticulum membrane]
(R-HSA-8876490)
0.508
2
UniProt:P27105 STOM
4
STOM [tertiary granule membrane]
(R-HSA-6800960)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [azurophil granule membrane]
(R-HSA-6800997)
STOM [specific granule membrane]
(R-HSA-6799569)
0.508
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
7
UniProt:P13073 COX4I1
2
COX4I1 [mitochondrial inner membrane]
(R-HSA-164305)
COX4I1 [mitochondrial intermembrane space]
(R-HSA-9865413)
0.483
2
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