Reactome | COX4I1 [mitochondrial inner membrane]

COX4I1 [mitochondrial inner membrane]

Stable Identifier

R-HSA-164305

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Cytochrome c oxidase subunit IV isoform 1, COX IV-1, Cytochrome c oxidase polypeptide IV

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX4I1,2 [mitochondrial inner membrane] (Homo sapiens)
        
        COX4I1 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX4I1,2 [mitochondrial inner membrane] (Homo sapiens)
        
        COX4I1 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P13073 COX4I1

Gene Names

COX4I1, COX4

Chain

transit peptide:1-22, chain:23-169

Reference Genes

BioGPS Gene:1327 COX4I1

COSMIC (genes):COX4I1 COX4I1

CTD Gene:1327 Q86WV2

dbSNP Gene:1327 COX4I1

ENSEMBL:ENSG00000131143 COX4I1

HGNC:2265 COX4I1

KEGG:hsa:1327 COX4I1

Monarch:1327 COX4I1

NCBI Gene:1327 COX4I1

OMIM:123864 COX4I1

UCSC:P13073 COX4I1

Reference Transcript

Other Identifiers

11715377_x_at

11759584_a_at

1327

16650613

16650619

16650621

16650623

16650625

16650627

16650629

16650631

16650633

16650635

16650637

16650639

16650641

16650643

16650645

16650647

16821614

18671084

18671085

18671086

18671087

18671088

18671089

200086_PM_s_at

200086_s_at

202698_PM_x_at

202698_x_at

213758_3p_at

213758_PM_at

213758_at

3672461

3672462

3672463

3672464

3672465

3672466

3672467

3672468

3672469

3672470

3672471

3672472

3672473

3672474

39027_at

7997702

A_14_P110646

A_23_P141029

A_23_P141032

A_23_P342348

GE59553

GO:0003824

GO:0004129

GO:0005215

GO:0005515

GO:0005654

GO:0005739

GO:0005743

GO:0005751

GO:0005758

GO:0005829

GO:0006091

GO:0006119

GO:0006123

GO:0016020

GO:0016491

GO:0031966

GO:0043226

GO:0045277

GO:0045333

GO:0055085

GO:1902600

HMNXSV003055492

Hs.113205.1.S1_3p_at

Hs.113205.1.S1_3p_s_at

ILMN_1652207

ILMN_2071898

PH_hs_0020120

TC16000665.hg

U90915_at

Participates

as a member of

Other forms of this molecule

COX4I1 [mitochondrial intermembrane space]

Inferred To

COX4 [mitochondrial inner membrane] (Drosophila melanogaster)

COX4I1 [mitochondrial inner membrane] (Bos taurus)

COX4I1 [mitochondrial inner membrane] (Canis familiaris)

COX4I1 [mitochondrial inner membrane] (Gallus gallus)

COX4I1 [mitochondrial inner membrane] (Sus scrofa)

cox4i1 [mitochondrial inner membrane] (Danio rerio)

cox4i1 [mitochondrial inner membrane] (Xenopus tropicalis)

Cox4i1 [mitochondrial inner membrane] (Mus musculus)

Cox4i1 [mitochondrial inner membrane] (Rattus norvegicus)

cox-4 [mitochondrial inner membrane] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENSP00000457513, ENSP00000457015, ENSG00000131143, ENSP00000253452, ENST00000253452, ENST00000562336, ENST00000561569

OpenTargets

ENSG00000131143

GeneCards

COX4I1

HPA

ENSG00000131143-COX4I1

PRO

P13073

Pharos - Targets

P13073

GlyGen

P13073

Orphanet

COX4I1

HMDB Protein

HMDBP03204

PDB

5Z62

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00403 MT-CO2	2	nascent MT-CO2 [mitochondrial matrix] (R-HSA-9902095) nascent MT-CO2 [mitochondrial inner membrane] (R-HSA-164302)	0.731	5
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.666	4
UniProt:P11182 DBT	11	Lipo-K105-DBT [mitochondrial matrix] (R-HSA-70017) LipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859167) Isobutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859151) Isovaleryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859144) 2-Methylbutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859145) DBT [mitochondrial matrix] (R-HSA-6792584) P276C Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865046) S399C Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865036) K313_Y338del Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865051) I98M Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865057) DBT [cytosol] (R-HSA-9714663)	0.564	2
UniProt:P00395 MT-CO1	1	nascent MT-CO1 [mitochondrial inner membrane] (R-HSA-164314)	0.564	3
UniProt:P31930 UQCRC1	1	UQCRC1 [mitochondrial inner membrane] (R-HSA-164284)	0.483	2
UniProt:P10809 HSPD1	6	HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.483	2
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.483	2
UniProt:P22695 UQCRC2	1	UQCRC2 [mitochondrial inner membrane] (R-HSA-164280)	0.483	2
UniProt:P04578 env	7	ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.462	2