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COX8A [mitochondrial inner membrane]
Stable Identifier
R-HSA-164313
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Cytochrome c oxidase polypeptide VIII, Cytochrome c oxidase subunit 8-2
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
CO binds to Cytochrome c oxidase (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
COX8A [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
COX8A [mitochondrial inner membrane] (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
COX8A [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
COX8A [mitochondrial inner membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
COX8A [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
COX8A [mitochondrial inner membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex IV assembly (Homo sapiens)
MT-CO1 and MT-CO2 complexes associate, installing heme moieties (Homo sapiens)
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
COX8A [mitochondrial inner membrane] (Homo sapiens)
holo-MT-CO1,2 complex [mitochondrial inner membrane] (Homo sapiens)
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
COX8A [mitochondrial inner membrane] (Homo sapiens)
MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
COX8A [mitochondrial inner membrane] (Homo sapiens)
holo-MT-CO1,2 complex [mitochondrial inner membrane] (Homo sapiens)
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
COX8A [mitochondrial inner membrane] (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
COX8A [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
COX8A [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10176 COX8A
Gene Names
COX8A, COX8, COX8L
Chain
transit peptide:1-25, chain:26-69
Reference Genes
BioGPS Gene:1351 COX8A
COSMIC (genes):COX8A COX8A
CTD Gene:1351 COX8A
dbSNP Gene:1351 COX8A
ENSEMBL:ENSG00000176340 COX8A
HGNC:2294 COX8A
KEGG:hsa:1351 COX8A
Monarch:1351 COX8A
NCBI Gene:1351 COX8A
OMIM:123870 COX8A
UCSC:P10176 COX8A
Reference Transcript
RefSeq:NM_004074.2 COX8A
Other Identifiers
11715458_a_at
11715459_x_at
1351
16726183
201119_PM_s_at
201119_s_at
3334126
3334127
3334130
3334131
3334132
3334133
3334134
38080_at
7940835
ADDON002451.hg
A_23_P52639
GE488941
GO:0003824
GO:0004129
GO:0005215
GO:0005515
GO:0005739
GO:0005743
GO:0005751
GO:0006091
GO:0006119
GO:0006123
GO:0016491
GO:0031966
GO:0043226
GO:0045277
GO:0045333
GO:0055085
GO:1902600
HMNXSV003026582
ILMN_1809495
J04823_rna1_at
PH_hs_0020157
TC11003499.hg
g4758043_3p_a_at
Participates
as a member of
COX8A,C [mitochondrial inner membrane] (Homo sapiens)
Inferred To
Cox8a [mitochondrial inner membrane]
(Mus musculus)
Cox8a [mitochondrial inner membrane]
(Rattus norvegicus)
COX8A [mitochondrial inner membrane]
(Bos taurus)
COX8A [mitochondrial inner membrane]
(Canis familiaris)
COX8A [mitochondrial inner membrane]
(Gallus gallus)
COX8A [mitochondrial inner membrane]
(Sus scrofa)
COX8 [mitochondrial inner membrane]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENST00000314133
,
ENSP00000321260
OpenTargets
ENSG00000176340
HPA
ENSG00000176340-COX8A
PRO
P10176
Pharos - Targets
P10176
Orphanet
COX8A
HMDB Protein
HMDBP03270
PDB
5Z62
,
8D4T
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.556
3
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