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What is Reactome ?
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Digital Preservation
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GNAS2 [plasma membrane]
Stable Identifier
R-HSA-164387
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
G(s) alpha subunit
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
ADM:CALCRL:RAMP2 binds G(s):GDP:Gbeta:Ggamma heterotrimer (Homo sapiens)
ADM:CALCLR:RAMP2:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP (Homo sapiens)
ADM:CALCLR:RAMP2:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma dissociates (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
ADORA2B:Ade-Rib:Heterotrimeric G-protein Gs:GTP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs:GDP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
ADORA2B:Ade-Rib binds heterometric G-protein Gs (Homo sapiens)
Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs:GDP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
ADORA2B:Ade-Rib:GsGTP dissociates (Homo sapiens)
ADORA2B:Ade-Rib:Heterotrimeric G-protein Gs:GTP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Prostacyclin signalling through prostacyclin receptor (Homo sapiens)
Activated prostacyclin receptor binds G-protein Gs (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Gs activation by prostacyclin receptor (Homo sapiens)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Glucagon signaling in metabolic regulation (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G(s):GTP activates Adenylyl cyclase (Homo sapiens)
ADCY5,6,8:G-alpha(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Glucagon:GCGR mediates GTP-GDP exchange (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G-protein with G(s) alpha:GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
PKA activation in glucagon signalling (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)
Activated Adenylyl cyclase synthesizes cyclic AMP (Homo sapiens)
ADCY5,6,8:G-alpha(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G(s):GTP activates Adenylyl cyclase (Homo sapiens)
ADCY5,6,8:G-alpha(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GLP1R binds GLP1 (Homo sapiens)
GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GLP1R binds GLP1R agonists (Homo sapiens)
GLP1R:GLP1R agonists [plasma membrane] (Homo sapiens)
GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GLP1R:GLP1 activates G(s) (Homo sapiens)
GLP-1:GLP-1R:Heterotrimeric G(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Heterotrimeric G(s) complex dissociates (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:p-Y419-SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC dissociates (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:p-Y419-SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G protein alpha (s):GTP binds SRC (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GPER1 signaling (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GPER:Heterotrimeric G-protein Gs binds ESTG (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Inactive G alpha (s) reassociates with G beta:gamma (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs:GDP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Glucagon-type ligand receptors (Homo sapiens)
GLP1R binds GLP1 (Homo sapiens)
GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Aquaporin-mediated transport (Homo sapiens)
Vasopressin regulates renal water homeostasis via Aquaporins (Homo sapiens)
AVP:AVPR2 Complex binds inactive heterotrimeric G(s) complex (Homo sapiens)
AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Homo sapiens)
AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
Heterotrimeric G(s) complex dissociates (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63092 GNAS
Gene Names
GNAS, GNAS1, GSP
Chain
initiator methionine:, chain:2-394
Reference Genes
BioGPS Gene:2778 GNAS
COSMIC (genes):GNAS GNAS
CTD Gene:2778 GNAS
dbSNP Gene:2778 GNAS
ENSEMBL:ENSG00000087460 GNAS
HGNC:4392 GNAS
KEGG:hsa:2778 GNAS
Monarch:2778 GNAS
NCBI Gene:2778 GNAS
OMIM:139320 GNAS
UCSC:P63092 GNAS
Reference Transcript
RefSeq:NM_080425.3 GNAS
RefSeq:NM_001309840.1 GNAS
RefSeq:NM_000516.7 GNAS
RefSeq:NM_080426.4 GNAS
RefSeq:NM_001077490.2 GNAS
RefSeq:NM_001077489.4 GNAS
RefSeq:NM_001077488.5 GNAS
Participates
as a member of
GNAS [plasma membrane] (Homo sapiens)
Cross References
RefSeq
NP_536351.1
,
NP_536350.2
,
NP_001070956.1
,
NP_001070957.1
,
NP_000507.1
,
NP_001296769.1
,
NP_001070958.1
OpenTargets
ENSG00000087460
ENSEMBL
ENST00000354359
,
ENSP00000360126
,
ENSP00000360136
,
ENST00000371085
,
ENST00000265620
,
ENST00000371095
,
ENSG00000087460
,
ENSP00000265620
,
ENSP00000346328
GeneCards
GNAS
PRO
P63092
Pharos - Targets
P63092
Orphanet
GNAS
HMDB Protein
HMDBP01781
PDB
8JSO
,
7DUQ
,
8F2A
,
7RTB
,
7UTZ
,
8HDO
,
7F23
,
8FLQ
,
7WUI
,
7WUQ
,
8JIP
,
8F0J
,
8UNX
,
8UO4
,
6ORV
,
7VUJ
,
7XZ5
,
7XTB
,
8GG4
,
8WC6
,
7F4F
,
8KGK
,
8PM2
,
8IZB
,
7C2E
,
8GEC
,
7PIU
,
7LJC
,
7VVN
,
7YS6
,
8GG0
,
7T9N
,
6M1I
,
7BZ2
,
8GFX
,
7TYL
,
7RG9
,
8FLT
,
7RBT
,
8HIX
,
8GGE
,
7XP4
,
7TYI
,
7X2D
,
7EPT
,
8YW5
,
6XOX
,
6E3Y
,
8K8J
,
6WI9
,
8UNW
,
7LLL
,
8GD9
,
7XOV
,
6P9X
,
7XKF
,
7X8S
,
8ZRK
,
7VUI
,
8JIR
,
8GE7
,
8GEB
,
7EZK
,
7F4I
,
7VVM
,
8UNS
,
8KH4
,
7T9I
,
7CX3
,
8JLO
,
8GG3
,
8SMV
,
7VVO
,
6M1H
,
8JLZ
,
7LLY
,
7YDP
,
7S1M
,
7JVQ
,
7D3S
,
6AU6
,
7XP6
,
8IW7
,
8TB0
,
8JIT
,
7TYW
,
7TYO
,
7TYH
,
8WC8
,
7X2C
,
8UO1
,
7RMH
,
8ZFJ
,
8GDB
,
6E67
,
6UUN
,
8WC3
,
8GE5
,
8F76
,
6WPW
,
8UO3
,
7XTC
,
8GG7
,
7F16
,
7DH5
,
8GEE
,
7XJI
,
7CX2
,
7LCI
,
7WQ4
,
8GEG
,
6NI3
,
7F54
,
8IRV
,
8GG8
,
6NIY
,
7TYN
,
6X19
,
8U8F
,
8WG7
,
6LPB
,
8HJ1
,
7DUR
,
6VCB
,
7XOU
,
7E14
,
7VAB
,
8F2B
,
8UNP
,
7BB7
,
7VUH
,
8GE4
,
8JIQ
,
8UNZ
,
8INR
,
8FU6
,
7TMW
,
8HTI
,
8JIS
,
5VAI
,
8UNR
,
8GFV
,
6WZG
,
8POK
,
8HJ0
,
7F0T
,
8GED
,
6LMK
,
7YP7
,
7P02
,
8GG2
,
7CX4
,
8YY8
,
8GEF
,
9AUC
,
6PB0
,
7WU2
,
8FLS
,
8GFW
,
7Y36
,
8GGF
,
8IW9
,
6WHC
,
7XTQ
,
8IOD
,
7XY7
,
7F1O
,
8E3Z
,
7CFN
,
5UZ7
,
8GE1
,
7F58
,
8GG6
,
7V9M
,
7V35
,
8UNY
,
7TZF
,
8JLK
,
7VBH
,
8GDA
,
8IQ4
,
8J9N
,
7Y3G
,
8W8R
,
8GE6
,
7F53
,
8GEI
,
8GEA
,
7CKX
,
7XKD
,
6X18
,
8GFZ
,
7WU3
,
7X2F
,
8GGA
,
7XT9
,
7Y35
,
8UO0
,
7PIV
,
7XP5
,
6LI3
,
7F1Z
,
8E3Y
,
8UNN
,
6P9Y
,
7WCN
,
7TYY
,
8E3X
,
7DHR
,
7MBX
,
7V9L
,
7X8R
,
7JOZ
,
8JLJ
,
8UNV
,
8GE3
,
7VVL
,
8JIU
,
8EL7
,
7VBI
,
8UO2
,
8IQ6
,
8WC5
,
7CKW
,
8JLR
,
7KI1
,
8JLQ
,
7VVJ
,
8GE9
,
7BPH
,
6VN7
,
8GGC
,
8HMP
,
8FLR
,
8X2K
,
7XT8
,
7DW9
,
7BW0
,
7CFM
,
8IW4
,
8UNO
,
8JPP
,
8XQL
,
6B3J
,
7KH0
,
7BB6
,
8UNM
,
7CZ5
,
7WCM
,
7TYX
,
8IOC
,
7E5E
,
8F0K
,
7S3I
,
5G53
,
8UNQ
,
7D7M
,
7XZ6
,
7XY6
,
8H4I
,
7XW6
,
8WC4
,
7F55
,
8HJ2
,
7AUE
,
6EG8
,
8GEJ
,
7JVP
,
8GW8
,
8GEH
,
7F4D
,
7CKZ
,
8XQR
,
7TYF
,
8FLU
,
6PB1
,
8GGB
,
8GFY
,
7EVM
,
8U26
,
7DHI
,
8UNL
,
7F24
,
7RA3
,
7WUJ
,
8JR9
,
8HDP
,
7JV5
,
8UNU
,
8GE2
,
6UVA
,
7RGP
,
7XJH
,
8UNT
,
6UUS
,
8WC7
,
8GG5
,
7CKY
,
8W8Q
,
7KI0
,
7LJD
,
7VVK
,
8GDZ
,
7F4H
,
8ZR5
,
8GG1
,
8GE8
,
8W88
,
8KH5
,
8WG8
,
6GDG
,
7CRH
,
8GG9
,
8HMV
,
6X1A
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P23786 CPT2
1
CPT2 [mitochondrial inner membrane]
(R-HSA-200994)
0.527
2
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
3
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