NucleoCapsid (NC) protein prevents self-priming by generating or stabilizing a thermodynamically favored RNA-DNA heteroduplex instead of the kinetically favored TAR hairpin seen in reverse transcription experiments in vitro (Driscoll and Hughes 2000).
De Clercq, E, Anne, J, Jonckheere, H
Varmus, HE, Hughes, SH, Coffin, JM
RNA-directed DNA polymerase activity of RTC with tRNA primer:RNA template [cytosol]
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