Insertion of gp41 fusion peptide into the target membrane

Stable Identifier
R-HSA-164521
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Insertion of gp41 fusion peptide into the target membrane
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Insertion of the N-terminal fusion peptide of the HIV gp41 protein is the first step in the fusion of viral and target cell membranes. Substitutions of polar amino acids at residues 2, 9, 15 and 26 of the N terminus of this peptide completely eliminated its ability to cause fusion, implicating these residues in gp41’s role in insertion and fusion. Studies have also shown that mutations in a stretch of residues from 36-64(568 to 596 of ENV protein) caused gp41 to become partially or completely defective in mediating membrane fusion, suggesting that conformation of the peptide is important for proper insertion and fusion to occur.
Literature References
PubMed ID Title Journal Year
8373393 Inhibition of HIV-1 infection by a fusion domain binding peptide from the HIV-1 envelope glycoprotein GP41

Jiang, S, Lin, K, Neurath, AR, Strick, N

Biochem Biophys Res Commun 1993
1438243 A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition

Oas, T, Matthews, T, Bolognesi, D, Wild, C, McDanal, C

Proc Natl Acad Sci U S A 1992
2191297 Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41

Risser, R, Freed, EO, Myers, DJ

Proc Natl Acad Sci U S A 1990
8474172 Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein

Sodroski, J, Thali, M, Bergeron, L, Repke, H, Helseth, E, Cao, J

J Virol 1993
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Bukrinsky, M  (2006-03-08)
Morrow, MP  (2006-03-08)
Reviewed
Reeves, J  (2006-06-12)
Created
D'Eustachio, P  (2005-05-24)
Cite Us!