Reactome | ATP5PF [mitochondrial inner membrane]

ATP5PF [mitochondrial inner membrane]

Stable Identifier

R-HSA-164532

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

F6, ATP synthase coupling factor 6, ATP5J

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Cristae formation (Homo sapiens)
    - F1Fo ATP synthase dimerizes (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5PF [mitochondrial inner membrane] (Homo sapiens)
      - F1Fo ATP synthase dimer [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5PF [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P18859 ATP5PF

Gene Names

ATP5PF, ATP5A, ATP5J, ATPM

Chain

transit peptide:1-32, chain:33-108

Reference Genes

BioGPS Gene:522 ATP5PF

COSMIC (genes):ATP5PF ATP5PF

CTD Gene:522 ATP5PF

dbSNP Gene:522 ATP5PF

ENSEMBL:ENSG00000154723 ATP5J

HGNC:847 ATP5PF

KEGG:hsa:522 ATP5PF

Monarch:522 ATP5PF

NCBI Gene:522 ATP5PF

OMIM:603152 ATP5PF

UCSC:P18859 ATP5PF

Reference Transcript

Other Identifiers

11715744_a_at

16924537

202325_PM_s_at

202325_s_at

36107_at

3927176

3927178

3927179

3927180

3927181

3927182

3927183

3927184

3927185

3927186

3927188

3927190

3927191

3927192

3927193

3927194

3927195

3927196

3927197

522

8069633

A_23_P154832

GE81056

GO:0003824

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0015078

GO:0015986

GO:0016874

GO:0021762

GO:0042776

GO:0043226

GO:0045259

GO:0045263

GO:0046933

GO:0048856

GO:0055085

GO:0055086

GO:1901135

GO:1902600

HMNXSV003010310

ILMN_1652806

ILMN_1772929

ILMN_2348093

M37104_at

PH_hs_0023210

g4502292_3p_a_at

Participates

as a member of

Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)

as a component of

ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)

Inferred To

ATP5PF [mitochondrial inner membrane] (Bos taurus)

ATP5PF [mitochondrial inner membrane] (Canis familiaris)

ATP5PF [mitochondrial inner membrane] (Gallus gallus)

ATP5PF [mitochondrial inner membrane] (Sus scrofa)

ATPsynCF6 [mitochondrial inner membrane] (Drosophila melanogaster)

Atp5pf [mitochondrial inner membrane] (Mus musculus)

Atp5pf [mitochondrial inner membrane] (Rattus norvegicus)

atp-4 [mitochondrial inner membrane] (Caenorhabditis elegans)

atp5pf [mitochondrial inner membrane] (Danio rerio)

Cross References

RefSeq

NP_001307196.1, NP_001307195.1, NP_001003701.1, NP_001003697.1, NP_001676.2, NP_001003703.1, NP_001003696.1

Guide to Pharmacology - Targets

807

OpenTargets

ENSG00000154723

ENSEMBL

ENSP00000382959, ENST00000284971, ENSP00000382966, ENSP00000382965, ENST00000400094, ENST00000400087, ENST00000400093, ENSP00000382962, ENST00000400090, ENSP00000389649, ENSP00000284971, ENSG00000154723, ENST00000457143

HPA

ENSG00000154723-ATP5PF

GeneCards

ATP5PF

PRO

P18859

Pharos - Targets

P18859

PDB

8H9G, 8H9U, 8H9S, 8H9V, 8H9T, 8H9K, 8H9R, 8KI3, 8H9N

HMDB Protein

HMDBP01282

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.643	4
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.643	3
UniProt:Q9H2H9 SLC38A1	1	SLC38A1 [plasma membrane] (R-HSA-212663)	0.527	2
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	4