Nef mediated activation of the T-cell receptor

Stable Identifier
R-HSA-164943
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Nef mediated activation of the T-cell receptor
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Nef drives the formation of lipid raft complexes.
Literature References
PubMed ID Title Journal Year
11070003 Lentivirus Nef specifically activates Pak2

Arora, VK, Molina, RP, Foster, JL, Blakemore, JL, Chernoff, J, Fredericksen, BL, Garcia, JV

J Virol 2000
11160719 Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX

Renkema, GH, Manninen, A, Saksela, K

J Virol 2001
16979207 CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable

Agopian, K, Wei, BL, Garcia, JV, Gabuzda, D

Virology 2007
10607567 Identification of the Nef-associated kinase as p21-activated kinase 2

Renkema, GH, Manninen, A, Mann, DA, Harris, M, Saksela, K

Curr Biol 1999
16188976 Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex

Raney, A, Kuo, LS, Baugh, LL, Foster, JL, Garcia, JV

J Virol 2005
10618429 The Nef protein of HIV-1 associates with rafts and primes T cells for activation

Wang, JK, Kiyokawa, E, Verdin, E, Trono, D

Proc Natl Acad Sci U S A 2000
16282498 Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation

Wei, BL, Arora, VK, Raney, A, Kuo, LS, Xiao, GH, O'Neill, E, Testa, JR, Foster, JL, Garcia, JV

J Virol 2005
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of defense response to virus (0050687)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Cross References
Mondo
Authored
Gillespie, ME  (2007-07-25)
Reviewed
Skowronski, J  (2007-08-07)
Created
Gillespie, ME  (2005-07-23)
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