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Release of the HIV mRNA and Crm1 from Rev in the cytoplasm
Stable Identifier
R-HSA-165028
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
,
nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Release of the HIV mRNA and Crm1 from Rev in the cytoplasm (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Interactions of Rev with host cellular proteins (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Release of the HIV mRNA and Crm1 from Rev in the cytoplasm (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The association of RanBp1 with RanGTP:CRM1:Rev promotes disassembly of the complex and release of the Rev:RNA cargo (Mahboobi et al. 2015).
Literature References
PubMed ID
Title
Journal
Year
25723178
The interaction of RNA helicase DDX3 with HIV-1 Rev-CRM1-RanGTP complex during the HIV replication cycle
Mahboobi, SH
,
Javanpour, AA
,
Mofrad, MR
PLoS ONE
2015
Participants
Input
RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complex [cytosol]
(Homo sapiens)
Output
HIV-1 unspliced RNA [cytosol]
(Human immunodeficiency virus 1)
RAN:GTP [cytosol]
(Homo sapiens)
RANBP1 [nuclear envelope]
(Homo sapiens)
REV (P04618) protein [cytosol]
(Human immunodeficiency virus 1)
Rev-multimer [cytosol]
(Human immunodeficiency virus 1)
XPO1 [cytosol]
(Homo sapiens)
Participates
as an event of
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Matthews, L (2005-07-27)
Rice, AP (2005-07-27)
Reviewed
Kumar, A (2007-02-01)
Created
Matthews, L (2005-07-27)
Rice, AP (2005-07-27)
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