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MTOR signalling
Stable Identifier
R-HSA-165159
DOI
10.3180/R-HSA-165159.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
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Target of rapamycin (mTOR) is a highly-conserved serine/threonine kinase that regulates cell growth and division in response to energy levels, growth signals, and nutrients (Zoncu et al. 2011). Control of mTOR activity is critical for the cell since its dysregulation leads to cancer, metabolic disease, and diabetes (Laplante & Sabatini 2012). In cells, mTOR exists as two structurally distinct complexes termed mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), each one with specificity for different sets of effectors. mTORC1 couples energy and nutrient abundance to cell growth and proliferation by balancing anabolic (protein synthesis and nutrient storage) and catabolic (autophagy and utilization of energy stores) processes.
Literature References
PubMed ID
Title
Journal
Year
21157483
mTOR: from growth signal integration to cancer, diabetes and ageing
Sabatini, DM
,
Zoncu, R
,
Efeyan, A
Nat. Rev. Mol. Cell Biol.
2011
Participants
Events
Inhibition of TSC complex formation by PKB
(Homo sapiens)
GTP loading by Rheb
(Homo sapiens)
Rag dimer formation
(Homo sapiens)
Formation of Ragulator complex
(Homo sapiens)
Ragulator binds Rag dimers
(Homo sapiens)
SLC38A9 binds Ragulator:Rag dimers
(Homo sapiens)
SLC38A9 transports L-Arg from lysosomal lumen to cytosol
(Homo sapiens)
Ragulator:Rag dimers:SLC38A9 bind mTORC1
(Homo sapiens)
Formation of active mTORC1 complex
(Homo sapiens)
AKT1S1 (PRAS40) binds mTORC1
(Homo sapiens)
Activated Akt1 phosphorylates AKT1S1 (PRAS40)
(Homo sapiens)
Phosphorylated AKT1S1:mTORC1 binds YWHAB
(Homo sapiens)
mTORC1 phosphorylates AKT1S1
(Homo sapiens)
mTORC1-mediated signalling
(Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK
(Homo sapiens)
Participates
as an event of
Signal Transduction (Homo sapiens)
Orthologous Events
MTOR signalling (Bos taurus)
MTOR signalling (Caenorhabditis elegans)
MTOR signalling (Canis familiaris)
MTOR signalling (Danio rerio)
MTOR signalling (Dictyostelium discoideum)
MTOR signalling (Drosophila melanogaster)
MTOR signalling (Gallus gallus)
MTOR signalling (Mus musculus)
MTOR signalling (Rattus norvegicus)
MTOR signalling (Saccharomyces cerevisiae)
MTOR signalling (Schizosaccharomyces pombe)
MTOR signalling (Sus scrofa)
MTOR signalling (Xenopus tropicalis)
Authored
Jupe, S (2015-01-23)
Reviewed
Zwartkruis, FJ (2015-05-14)
Created
de Bono, B (2005-08-01)
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