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p-S939,S1130,T1462-TSC2 [cytosol]
Stable Identifier
R-HSA-165164
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S1130,S939,T1462-TSC2, p-S93, S1130,T1462-TSC2
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Inhibition of TSC complex formation by PKB (Homo sapiens)
Phosphorylation of TSC2 by PKB (Homo sapiens)
p-S939,S1130,T1462-TSC2 [cytosol] (Homo sapiens)
Phosphorylation of complexed TSC2 by PKB (Homo sapiens)
TSC1:Inhibited TSC2-1-P [cytosol] (Homo sapiens)
p-S939,S1130,T1462-TSC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49815 TSC2
Gene Names
TSC2, TSC4
Chain
chain:1-1807
Reference Genes
COSMIC (genes):TSC2 TSC2
dbSNP Gene:7249 TSC2
ENSEMBL:ENSG00000103197 TSC2
Participates
as a component of
TSC1:Inhibited TSC2-1-P [cytosol] (Homo sapiens)
as an output of
Phosphorylation of TSC2 by PKB (Homo sapiens)
Other forms of this molecule
p-S939,T1462-TSC2 [cytosol]
TSC2 [cytosol]
p-S1387-TSC2 [cytosol]
Inferred To
phospho-Tsc2 [cytosol]
(Mus musculus)
phospho-Tsc2 [cytosol]
(Rattus norvegicus)
phospho-gig [cytosol]
(Drosophila melanogaster)
phospho-TSC2 [cytosol]
(Canis familiaris)
phospho-TSC2 [cytosol]
(Sus scrofa)
phospho-p-S939,S1130,T1462-TSC2 [cytosol]
(Bos taurus)
phospho-p-S939,S1130,T1462-TSC2 [cytosol]
(Dictyostelium discoideum)
phospho-p-S939,S1130,T1462-TSC2 [cytosol]
(Gallus gallus)
phospho-tsc2 [cytosol]
(Schizosaccharomyces pombe)
phospho-tsc2 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 939
Coordinate
939
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1130
Coordinate
1130
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 1462
Coordinate
1462
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.945
15
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.937
12
UniProt:Q92574 TSC1
2
TSC1 [cytosol]
(R-HSA-5672338)
TSC1 [plasma membrane]
(R-HSA-165169)
0.935
13
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.87
9
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.851
8
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.816
6
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.675
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.571
3
UniProt:O00141 SGK1
4
p-T256,S422-SGK1 [nucleoplasm]
(R-HSA-9612512)
p-T256,S422-SGK1 [cytosol]
(R-HSA-6795449)
p-S422-SGK1 [cytosol]
(R-HSA-6795313)
SGK1 [cytosol]
(R-HSA-2682356)
0.563
4
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.544
2
UniProt:Q9P0N9 TBC1D7
1
TBC1D7 [cytosol]
(R-HSA-8854154)
0.528
3
UniProt:P03126 VE6
0.527
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.508
2
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