Reactome | Formation of TSC1:TSC2 complex

Formation of TSC1:TSC2 complex

Stable Identifier

R-HSA-165179

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A membrane-associated TSC1 (hamartin) binds TSC2 (tuberin) and recruits it to the plasma membrane where it can exert its function as a GAP (GTPase activating protein) for the small GTPase RHEB (Cai et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16636147	Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning Kim, J, Guo, R, Walker, CL, Shen, J, Kiguchi, K, Cai, SL, Short, JD, Tee, AR, Bergeron, JM, Johnson, CL	J. Cell Biol.	2006
15589136	Signaling pathways: the benefits of good communication White, MF, Fisher, TL	Curr Biol	2004