Reactome | Formation of TSC1:TSC2 complex

Formation of TSC1:TSC2 complex

Stable Identifier

R-HSA-165179

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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A membrane-associated TSC1 (hamartin) binds TSC2 (tuberin) and recruits it to the plasma membrane where it can exert its function as a GAP (GTPase activating protein) for the small GTPase RHEB (Cai et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
15589136	Signaling pathways: the benefits of good communication Fisher, TL, White, MF	Curr Biol	2004
16636147	Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning Cai, SL, Tee, AR, Short, JD, Bergeron, JM, Kim, J, Shen, J, Guo, R, Johnson, CL, Kiguchi, K, Walker, CL	J. Cell Biol.	2006