A membrane-associated TSC1 (hamartin) binds TSC2 (tuberin) and recruits it to the plasma membrane where it can exert its function as a GAP (GTPase activating protein) for the small GTPase RHEB (Cai et al. 2006).
Kim, J, Guo, R, Walker, CL, Shen, J, Kiguchi, K, Cai, SL, Short, JD, Tee, AR, Bergeron, JM, Johnson, CL
White, MF, Fisher, TL
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