Inhibition of TSC complex formation by PKB

Stable Identifier
R-HSA-165181
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Inhibition of TSC complex formation by PKB
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Phosphorylation of TSC2 by PKB disrupts TSC1/TSC2 heterodimer formation (Hay & Sonenberg 2004). TSC2 function is affected in at least two ways: first, phosphorylation decreases the activity of TSC2; second, phosphorylation destabilizes the TSC2 protein. This destabilization is achieved by disrupting complex formation between TSC1 and TSC2 and inducing ubiquination of the free TSC2 (Inoki et al. 2002). Phosphorylation of complexed TSC2 by PKB may result in the dissociation of the TSC1:TSC2 complex (Proud 2002).
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Orthologous Events
Inhibition of TSC complex formation by PKB (Bos taurus)
Inhibition of TSC complex formation by PKB (Dictyostelium discoideum)
Inhibition of TSC complex formation by PKB (Drosophila melanogaster)
Inhibition of TSC complex formation by PKB (Mus musculus)
Inhibition of TSC complex formation by PKB (Rattus norvegicus)
Inhibition of TSC complex formation by PKB (Schizosaccharomyces pombe)
Inhibition of TSC complex formation by PKB (Sus scrofa)
Cross References
BioModels Database
Authored
Jupe, S  (2015-01-23)
Reviewed
Zwartkruis, FJ  (2015-05-14)
Created
de Bono, B  (2005-08-02)
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