FMO1:FAD oxidizes HTAU to TAU

Stable Identifier
R-HSA-1655453
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
H(+) + hypotaurine + NADPH + O2 = H2O + NADP(+) + taurine, Oxidation of hypotaurine to taurine
ReviewStatus
5/5
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FMO1:FAD oxidizes HTAU to TAU
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FMO1:FAD (flavin monooxygenase 1 : FAD complex) catalyzes the reaction of hypotaurine (HTAU) with NADPH + H+ and O2 to form taurine (TAU), NADP+, and water (Veeravalli et al. 2020).
Literature References
PubMed ID Title Journal Year
32156684 Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine

Phillips, IR, Shephard, EA, Veeravalli, S, Varshavi, D, Everett, JR, Freire, RT

Drug Metab Dispos 2020
Participants
Input
Output
Participates
as an event of
Catalyst Activity

hypotaurine dehydrogenase activity of FMO1:FAD [endoplasmic reticulum membrane]

Physical Entity
FMO1:FAD [endoplasmic reticulum membrane] (Homo sapiens)
Activity
hypotaurine dehydrogenase activity (GO:0047822)
Orthologous Events
FMO1:FAD oxidizes HTAU to TAU (Bos taurus)
FMO1:FAD oxidizes HTAU to TAU (Caenorhabditis elegans)
FMO1:FAD oxidizes HTAU to TAU (Canis familiaris)
FMO1:FAD oxidizes HTAU to TAU (Danio rerio)
FMO1:FAD oxidizes HTAU to TAU (Dictyostelium discoideum)
FMO1:FAD oxidizes HTAU to TAU (Mus musculus)
FMO1:FAD oxidizes HTAU to TAU (Rattus norvegicus)
FMO1:FAD oxidizes HTAU to TAU (Sus scrofa)
FMO1:FAD oxidizes HTAU to TAU (Xenopus tropicalis)
Cross References
Rhea
Reviewed
D'Eustachio, P  (2011-10-13)
Created
Jassal, B  (2011-10-12)
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