Expression of Squalene Monooxygenase (SQLE)

Stable Identifier
R-HSA-1655844
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum membrane
ReviewStatus
5/5
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Expression of Squalene Monooxygenase (SQLE)
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SREBF1A (SREBP1A) and SREBF2 (SREBP2) bind the promoter of the Squalene Monooxygenase (SQLE) gene and enhance transcription (Sakakura et al. 2001, Nagai et al. 2002, Murphy et al. 2006, Reed et al. 2008, reviewed in Horton et al. 2002). The SQLE gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
Literature References
PubMed ID Title Journal Year
8626488 Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells

Sakakibara, J, Nakamura, Y, Shibata, A, Ono, T, Izumi, T

J Biol Chem 1996
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SREBP1A,2:SQLE gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-09-28)
Reviewed
Liang, G  (2012-08-26)
Created
May, B  (2011-10-13)
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